Acute cholangitis: a literature review

Authors

  • Cesár A. O. Orozco Department of General Surgery, Dr. Juan I Menchaca Public Hospital of Guadalajara, Guadalajara, Mexico
  • Alberto B. Fuentes Department of General Surgery, Dr. Juan I Menchaca Public Hospital of Guadalajara, Guadalajara, Mexico
  • Félix O. Gutiérrez Autonomous University of Guadalajara, Guadalajara, Jalisco, Mexico
  • Jose M. Z. Torres Autonomous University of Guadalajara, Guadalajara, Jalisco, Mexico http://orcid.org/0000-0002-1741-4117

DOI:

https://doi.org/10.18203/2349-2902.isj20223184

Keywords:

Cholangitis, Charcot, Biliary tract

Abstract

Acute cholangitis is a disease that occurs when a stricture or obstruction of the bile duct causes cholestasis and/or infection. Biliary stricture or obstruction elevates the pressure in the biliary system and causes reflux of microorganisms or endotoxins from the infected bile into the systemic circulation, which induces a systemic inflammatory response. The Charcot triad provides high specificity, however, due to its low sensitivity (50-70%), it is very limited to make a diagnosis of cholangitis alone. Therefore, the most current guidelines suggest specific criteria for diagnosis. Antibiotic treatment is a fundamental pillar in the management of patients with cholangitis. The treatment must be carried out depending on the severity (grade I-III).

References

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Published

2022-11-28

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Section

Review Articles