Neck node metastasis: the strong prognostic indicator in oral cavity malignancy

Authors

  • P. G. Chougule Department of Surgery, Krishna Institute of Medical Sciences, Karad, Satara - 415110, Maharashtra, India
  • R. D. Jaykar Department of Surgery, Dr. Vaishampayan Memorial Government Medical College, Solapur - 413003, Maharashtra, India

DOI:

https://doi.org/10.18203/2349-2902.isj20163600

Keywords:

Oral cavity malignancy, Prognostic indicator, Neck, Lymph node metastasis

Abstract

Background: Oral cavity malignancy is common in INDIA. Many patients come with neck node metastasis, result in poor prognosis, patients treated in early stage, results in good prognosis. As Lymph node metastasis is strong prognostic indicator in oral cavity malignancy. The objective of the study was to assess prognosis of oral cavity malignancy (Squamous Cell carcinoma) with respect to number of neck node metastasis.

Methods: Total 106 patients of Oral cavity malignancy, were treated in surgical oncology, unit in Krishna Hospital Karad between Oct 1997 to Dec 2004. Operative procedures were WE (Wide excision) and RND (Radical neck dissection) and SOHND (Supraomohoid neck dissection) with post-operative Radiotherapy and Chemotherapy. Histopathological assessment was done for primary lesions and neck node metastasis in operative specimen. Analysis and summation of data was done by using statistical software SPSS.

Results: There were 81 patients with no neck node metastasis (NO). 14 with 1 to 3 neck node metastasis, their mortality was 35.7% (at 1 year follow up ) 6 with 4 to 7 neck node metastasis, their mortality was 66.7%, 4 with 7 to 9 neck node metastasis, their mortality was 75%. 1 patient was having above 9 neck node metastasis, died with other disease.

Conclusions: Lymph node metastasis is a strong prognostic indicator in oral cavity malignancy. If patients are treated in early stage (stage 1 and 2) survival is significantly better.

References

Mehrotra R, Singh M, Kumar D. Age specific incidence rate and pathological spectrum of oral cancer in Allahabad. Indian J of Medical Sciences. 2003;57:400-4.

National cancer registry Programme Biennial Report (1988-89) of the national cancer registry programme, New Delhi Indian council of Medical research, 1992.

Padmakumary GIS, Varghese C. Annual report 1997, Hospital cancer registry Thiruanthapuram, Regional cancer. 2000:3-4.

Jayant K, Deo MG. Oral cancer and cultural Practices in relation to bitle quid and tobacco chewing and smoking Cancer. Detct Preo. 1986;9(34):207-13.

Jayant K. Notani PN, Rao RS, Desai PB. Epidemiology of oral cancer Publication of the professional Education Division, Tata Memorial Hospital Mumbai. 1991:1-17.

Bailey and Loves Short practice of surgery 23rd Edi. 2000. pp. 635.

Kalnins IK, Leonard AG, Sako K, Razack MS, Shedd DP. Correlation between prognosis and degree of lymph node involvement in carcinoma of oral cavity. Am J Surg. 1977;134(4):450-4.

Franceschi D, Gupta R, Siro RH. Improved survival in the treatment of squamous carcinoma of the oral tongue. 1993;166(4):360-5.

Close LG, Brown PM, Vuitch MF. Microvascular invasion and survival in cancer of the oral cavity and oropharynx. Archives of otolaryngology, Head and Neck surgery. 1989;115(11):1304-9.

Takigi M, Kayano T, Yamamoto H. Causes of oral tongue cancer treatment failures: Analysis of autopsy cases. Cancer. 1992;69(5):1081-7.

Snow GB, Leemans CR. Prognostic factors of neck node metastasis. Head and neck. 1993;3:513-8.

Clinical Trials Gov. Identifier. NCT00193765. Elective Vs Therapeutic Neck Dissection in the Treatment of Early Node Negative Squamous carcinoma of the oral cavity.

Pinsolle J, Pinsolle V, Majaufre C. Prognostic value of histologic findings in neck dissection for squamous cell carcinoma. Arch. Otolarygol head and neck surgery. 1997;123:145-8.

Tytor M, Olofsson J. Prognostic factors in oral cavity carcinomas. Acta Otolaryngol. 1992:492.

Nagral S, Sankhe M, Patel GV. Experience with the pectoralis major myocutaneous flap for head and neck reconstruction in general surgical unit. Journal of post graduate medicine. 1992;38(3):119-23.

Pillsbury HC, Clark MA, Rationale for therapy of NO neck. Laryngoscope. 1997;107:1294-315.

Eeiss MH, Harrison LB, Isaacs RS. Use of decision analysis in planning a management Strategy for the stage NO neck. Arch Otolarygol Head and neck surgery. 1994;120:699-702.

Traynor SJ, Cohen JI, Gray J, et.all. Selective neck dissection and management of neck node-positive neck Am. J. of surg. 1996;172;654-657.

Spiro RH, Morgan GJ, Srong EW, Shah JP. Supraomohoid neck dissection. A J of surg. 1996;172:650-3.

Medina JE, Byers RM. Supraomohoid neck dissection rationale. Indications surgical technique. Head and neck. 1989;11:111-2.

Majoufre C, Faucher A. Supraomohoid neck dissection in cancer of oral cavity. Am J of surg. 1999;178(1):73-7.

Schiff BA, Roberts DB. Selective VS Modified radical neck dissection and post-operative radiotherapy VS observation in the treatment of Squamous cell carcinoma of oral tongue. Arch Otolaryngol Head and neck surg. 2005;131(10):874-8.

Blot WJ. McLaghlin J.K. Winn DM. Smoking and drinking in relation to oral and pharyngeal cancer. J; cancer Res. 1988;48(11):3282-7.

Sayed M Mirbod, Stephen I Abing. Tobacco Associated Lesions of the Oral Cavity, Part 2, malignant Lesions. J Can Dent. Assoc. 2000;66:308-11.

Rao DN, Ganesh B, Rao RS, Desai PB, Risk assessment of tobacco, alcohol and diet in oral cancer a case control study. Int J Cancer. 1994;58(4):469-73.

Jayant K, Balkrishna Y Sanghvi ID, Jassawala DJ. Quantification of the role of smoking and chewing tobacco in oral, Pharyngeal and Oesophageal Cancers. Br J Cancer. 1997;35(2):232-4.

American joint committee on cancer. Manual for staging of cancer. 4th Ed. Philadelphia J. B. Lippincot ca. 1992;33:35.

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Published

2016-12-10

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Original Research Articles