A retrospective single centre study on histopathological analysis of cholecystectomy specimens in a tertiary care centre in India
Keywords:Gall bladder carcinoma, Cholecystectomy, Histopathology
Background: Gall bladder carcinoma is the 5th most common gastrointestinal malignancy which has a poor 5-year survival rate, carrying dismal prognosis. Diagnosing chronic cholecystitis from gall bladder cancer is challenging. Early detection of gall bladder carcinoma allows for the possibility of radical resection surgery, which has been shown to increase patient survival.
Methods: A retrospective histopathological analysis was conducted at a tertiary care centre to evaluate the incidence of gall bladder carcinoma. A total of 1728 cholecystectomy samples were evaluated from all age groups for a period of 6 years.
Results: Chronic cholecystitis was the most common impression on histopathological analysis, showing females have high predominance of developing gall bladder disease including malignancy. The incidence of gall bladder carcinoma was found to be 0.46 % with 8 cases of adenocarcinoma diagnosed, which were not diagnosed preoperatively.
Conclusions: If missed, gall bladder cancer can progress rapidly and has a significant fatality risk if it is not detected in time. We conclude that all histopathology specimens be sent for routine analysis, to rule out gall bladder cancer, which if resected early can improve the survival of the patients.
Jones MW, Deppen JG. Physiology, Gallbladder. StatPearls. 2020.
Rudnisky FCC, Assarzadegan N. Anatomy, histology & embryology. Pathologyoutlines.com. 2022. Available at: https://www.pathology outlines.com/topic/gallbladderhistology.html. Accessed on 15 April 2023.
Patel AM, Yeola M, Mahakalkar C. Demographic and Risk Factor Profile in Patients of Gallstone Disease in Central India. Cureus. 2022;14(5):e24993.
Stinton LM, Shaffer EA. Epidemiology of Gallbladder Disease: Cholelithiasis and Cancer. Gut Liver. 2012;6(2):172-87.
Dutta U, Bush N, Kalsi D, Popli P, Kapoor VK. Epidemiology of gallbladder cancer in India. Chinese Clin Oncol. 2019;8(4):4.
Patil M, Londhe MM, Margam S, Iqbal J. Spectrum of Lesions of Gall Bladder Experience of Five Years at Tertiary Care Hospital. Ann Pathol Lab Med. 2018;5(9):A779-84.
Bansal A, Akhtar M, Bansal A. A clinical study: prevalence and management of cholelithiasis. Int Surg J. 2014;1(3):134.
Mathur SK, Duhan A, Singh S, Aggarwal M, Aggarwal G, Sen R, Singh S, Garg S. Correlation of gallstone characteristics with mucosal changes in gall bladder. Trop Gastroenterol. 2012;33(1):39-44.
Goetze TO. Gallbladder carcinoma: Prognostic factors and therapeutic options. World J Gastroenterol. 2015;21(43):12211-7.
Sachdeva S, Khan Z, Ansari MA, Khalique N, Anees A. Lifestyle and gallstone disease: scope for primary prevention. Indian J Comm Med. 2011;36(4):263-7.
Kulkarni AM, Jadhav ED, Ramteke RV. Histopathological spectrum of gall bladder lesions. Int J Res Med Sci. 2020;8(3):1056.
Kotasthane VD, Kotasthane DS. Histopathological spectrum of gall Bladder diseases in cholecystectomy specimens at a Rural tertiary hospital of Purvanchal in North India-Does it differ from South India? IP Arch Cytol Histopathol Res. 2020;5(1):91-5.
Almas T, Murad MF, Khan MK, Ullah M, Nadeem F, Ehtesham M, Zaidi SMJ. The Spectrum of Gallbladder Histopathology at a Tertiary Hospital in a Developing Country: A Retrospective Study. Cureus. 2020;12(8):e9627.
Kishore R, Nundy S, Mehrotra S, Metha N, Mangla V, Lalwani S. Strategies for Differentiating Gallbladder Carcinoma from Xanthogranulomatous Cholecystitis-a Tertiary Care Centre Experience. Indian J Surg Oncol. 2017;8(4):554-9.
Kane RA, Jacobs R, Katz J, Costello P. Porcelain gallbladder: ultrasound and CT appearance. Radiology. 1984;152(1):137-41.
Morimoto M, Matsuo T, Mori N. Management of Porcelain Gallbladder, Its Risk Factors, and Complications: A Review. Diagnostics (Basel). 2021;11(6):1073.
Zhu AX, Hong TS, Hezel AF, Kooby DA. Current management of gallbladder carcinoma. Oncologist. 2010;15(2):168-81.
Dutta EK, Lewis MG, Albert S. Risk factors associated with gall bladder cancer in high incidence areas in India: a systematic review protocol. BMJ Open. 2022;12(3):e056849.
Phadke PR, Mhatre SS, Budukh AM, Dikshit RP. Trends in gallbladder cancer incidence in the high- and low-risk regions of India. Indian J Med Paediatric Oncol. 2019;40(1):90-3.
Kanthan R, Senger JL, Ahmed S, Kanthan SC. Gallbladder Cancer in the 21st Century. J Oncol. 2015;967472.