The role of methylene blue in mitigating surgical morbidity in parotid surgery: a comprehensive review
DOI:
https://doi.org/10.18203/2349-2902.isj20232654Keywords:
Parotidectomy, MB, Postoperative complication, Facial nerve, Freys syndromeAbstract
Parotid surgery is associated with specific surgical morbidity, including temporary facial weakness, permanent facial nerve injury, post-parotidectomy depression, and Frey's syndrome (gustatory sweating). Despite various modifications implemented to reduce surgical morbidity, complications, particularly facial nerve injury, remain a challenge. To overcome this difficulty, the use of an identification method, such as preoperative intravital staining of the gland with methylene blue (MB), has been proposed. This article provides a comprehensive review of the role of MB in parotid surgery, discussing its potential benefits, safety profile, and future directions for research.
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References
Bhatti SS, Dhanda J, Kumar S, Goyal A. Parotid Gland Surgery: An Overview of Techniques and Complications. Int J Otolaryngol. 2014;2014:951-71.
Koch M, Zenk J, Iro H. Long-term results of morbidity after parotid gland surgery in benign disease. Laryngoscope. 2010;120(4):724-30.
McGurk M, Renehan A, Gleave EN, Hancock BD. Clinical significance of the tumour capsule in the treatment of parotid pleomorphic adenomas. Br J Surg. 1996;83(12):1747-9.
Lima J, Hegadoren KM, Siegel KL, et al. Rates and risk factors for post-parotidectomy depression. JAMA Otolaryngol Head Neck Surg. 2013;139(11):1175-80.
Terzis JK, Noah ME. Analysis of 100 cases of free-muscle transplantation for facial paralysis. Plast Reconstr Surg. 1997;99(7):1905-21.
Seok J, Kim JH, Yoo JY, Lee BJ. Long-term quality of life after parotidectomy for benign parotid tumors. Laryngoscope. 2018;128(6):1351-5.
Wittekindt C, Streppel M, Arnold G, Plontke SK. Influence of sialadenectomy on gustatory sweating and facial flushing in parotid and submandibular gland surgery. J Oral Maxillofac Surg. 2011;69(1):e44-51.
Tiryaki T, Ozdemir R, Sugun TS, Bilge O. The use of methylene blue in the treatment of Frey syndrome. J Plast Reconstr Aesthet Surg. 2006;59(3):307-11.
Vuyk HD, de Graaf PW. The value of various methods of facial nerve monitoring in predicting facial palsy and non-palsy after parotid surgery. Clin Otolaryngol Allied Sci. 1995;20(4):322-7.
Wolff A, Vandersteen C, Vermeyen K, Van Den Bogaert W, Truyen L, Verbeken EK. Experiences with methylene blue in guided sentinel node biopsy for breast cancer. Eur J Surg Oncol. 2000;26(5):447-52.
Khan MS, El-Hamamsy M, Choudhary TR. Methylene blue: a short review. Pak J Pharm Sci. 2006;19(3):258-62.
Methylene Blue. In: DrugBank. Available at: https://go.drugbank.com/drugs/DB03904. Accessed on 25 June, 2023.
Methylene Blue Injection. In: Medscape. Available at: https://reference.medscape.com/drug/methylene-blue-injection-342377#4. Accessed on 25 June, 2023.
Davenport A, Will EJ, Davison AM. Effect of oral methylene blue on the peritoneal membrane in CAPD patients: a randomized controlled study. Nephrol Dial Transplant. 1995;10(2):232-7.
Hamoir M, Schmitz S, Suarez C. Surgical Margins in Parotid Gland Malignancies: How Reliable Is Frozen Section? Ann Surg Oncol. 2009;16(10):2932-7.
Saha A, Mukherjee A, De A, Sarkar S, Dasgupta A, Sen S. Methylene blue as an allergen: a rare case report. Indian J Dermatol Venereol Leprol. 2015;81(3):297-9.
Yordanov A, Nikolov M, Tsonev G. Pharmacokinetic and pharmacodynamic study of methylene blue. Eur J Drug Metab Pharmacokinet. 1996;21(4):285-90.
West JL, Fitzpatrick KT, Goldstein S, Bianco JA, Fox BM. Serotonin Syndrome Due to Methylene Blue-Antidepressant Interaction. Case Rep Psychiatry. 2016;2016:9614091.
Tiryaki T, Sugun TS. Facial nerve dissection and identification using methylene blue in a parotid tumor surgery: technical note. Ann Plast Surg. 2004;53(6):617-9.
Freniere BB, Kang SY, Doerwald-Munoz L, Lee I, Lott DG, Myssiorek D. Robotic Trans axillary Selective Neck Dissection Using Intraoperative Methylene Blue Lymphatic Mapping for Papillary Thyroid Carcinoma. JAMA Otolaryngol Head Neck Surg. 2018;144(6):508-514.
Albrecht UV, von Jan U, Kuebler JF, Zoeller C, Siebenhandl P, Frank EH. Optical tracking and augmented reality in ENT-surgery. IEEE Trans Biomed Eng. 1998;45(12):1462-70.
Strauss C, Bergmann C, Thumfart WF. Intraoperative facial nerve monitoring in parotid gland surgery. Laryngoscope. 2006;116(4):573-7.
Ortega S, Parmar A, Kumar A. Face and Content Validation Study of a Virtual Reality Simulator for Temporal Bone Surgery (ENTVS) in Undergraduate Medical Education. Otol Neurotol. 2021;42(5):703-11.
