Progressive hemifacial atrophy or Parry Romberg syndrome case report and literature review

Abstract

Parry-Romberg syndrome is a condition characterized mainly by left-sided hemifacial atrophy that affects skin, subcutaneous tissue, muscle, and bone. The pathophysiology is not established and several theories have been proposed, among which lymphocytic neurovasculitis manifested as a chronic vascular lesion measured by incomplete endothelial regeneration stands out. The actual treatment consists of autologous fat transfer, making voluminous grafts to restore symmetry and improve the quality of the skin. An overcorrection is recommended to compensate for the reabsorption estimated of up to 80%. The treatment consists of repeated applications until correction is achieved, there is currently no consensus regarding the preparation of the graft. The objective of this work is to propose an alternative to conventional treatment by enriching fatty tissue with platelet-rich plasma, which favors the formation of extracellular matrix, collagen fibers, and angiogenesis in an accelerated manner. We conclude that the use of platelet-rich plasma significantly improves skin quality and fat graft integration.