Platelet rich plasma: a novel therapy in chronic wounds
DOI:
https://doi.org/10.18203/2349-2902.isj20232323Keywords:
Chronic wounds, Non-healing wounds, Ulcers, Platelet-rich plasma, PRP, Autologous platelet gel, Wound healingAbstract
Background: Chronic non-healing wounds/ulcers present a significant healthcare issue globally. Utilizing platelet rich plasma (PRP) to treat these wounds/ulcers has gained attention due to its potential therapeutic properties.
Methods: Our study examined 25 patients with chronic wounds/ulcers who received a single PRP injection and topical autologous platelet gel application. Treatment efficacy and safety were assessed by tracking wound size reduction and adverse events.
Results: Treatment significantly reduced wound size in all patients, with 56% showing over 90% reduction as early as four weeks post-treatment. No complications related to the PRP treatment were noted, aligning with previous studies suggesting PRP as a safe and effective treatment for non-healing wounds/ulcers. Further studies with more extensive samples and controls are necessary for protocol optimization.
Conclusions: PRP injections and autologous platelet gel application present a promising, safe, and effective treatment method for chronic non-healing wounds/ulcers, potentially improving healing times and patient outcomes. Further research is needed for optimal PRP treatment protocol determination.
References
Gottrup F, Apelqvist J, Price P. Outcomes in controlled and comparative studies on non-healing wounds: recommendations to improve the quality of evidence in wound management. J Wound Care. 2010;19(6):237-68.
Anitua E, Sanchez M, Nurden AT, Nurden P, Orive G, Andia I. New insights into and novel applications for platelet-rich fibrin therapies. Trends Biotechnol. 2006;24(5):227-34.
Li M, Li Y, Liang Y, Li X, Li H. Platelet-rich plasma therapy improves the outcomes of surgery for dermal cysts: a randomized controlled trial. Dermatol Surg. 2017;43(2):255-63.
Scuderi N, Ceccarelli S, Onesti MG, Fioramonti P, Guidi C, Romano F, et al. Human adipose-derived stromal cells for cell-based therapies in the treatment of systemic sclerosis. Cell Transplant. 2013;22(5):779-95.
Carter MJ, Fylling CP, Parnell LK. Use of platelet rich plasma gel on wound healing: a systematic review and meta-analysis. Eplasty. 2011;11:e38.
Driver VR, Hanft J, Fylling CP, Beriou JM. A prospective, randomized, controlled trial of autologous platelet-rich plasma gel for the treatment of diabetic foot ulcers. Ostomy Wound Manage. 2006;52(6):68-74.
Lacci KM, Dardik A. Platelet-rich plasma: support for its use in wound healing. Yale J Biol Med. 2010;83(1):1-9.
Eo S, Lee JY, Kwak JH. The effect of platelet-rich plasma on the outcome of patients treated with a vacuum-assisted closure system for diabetic foot infections. Wound Repair Regen. 2016;24(1):153-60.
Anitua E, Sánchez M, Nurden AT, Nurden P, Orive G, Andía I. New insights into and novel applications for platelet-rich fibrin therapies. Trends Biotechnol. 2006;24(5):227-34.
Foster TE, Puskas BL, Mandelbaum BR, Gerhardt MB, Rodeo SA. Platelet-rich plasma: from basic science to clinical applications. Am J Sports Med. 2009;37(11):2259-72.
Frykberg RG, Driver VR, Carman D, Lucero B, Borris-Hale C, Fylling CP, et al. Chronic wounds treated with a physiologically relevant concentration of platelet-rich plasma gel: a prospective case series. Ostomy Wound Manage. 2010;56(6):36.
Xiong Y, Mahmood K, Chong KT. Efficacy of platelet-rich plasma for the treatment of chronic wounds: a systematic review and meta-analysis. Diabet Foot Ankle. 2017;8(1):1369862.
Wrotniak M, Bielecki T, Gaździk TS. Current opinion about using the platelet-rich gel in orthopedics and trauma surgery. Ortop Traumatol Rehabil. 2007;9(3):227-38.
De Angelis B, D’Autilio M, Tschon M. Platelet-rich plasma to treat chronic, non-healing ulcers: a case series. Wounds. 2015;27(8):208-14.
Picard F, Hersant B, Bosc R. Efficacy of injection of platelet-rich plasma for the treatment of diabetic foot ulcer: a systematic review and meta-analysis. Wound Repair Regen. 2019;27(2):170-82.
