Breast cancer with synchronous renal cell carcinoma: a rare case of dual malignancy


  • Ravi Ranjan Department of Surgery, Lady Hardinge Medical College, New Delhi, India
  • Mangipudi Surya Pratap Department of Surgery, Lady Hardinge Medical College, New Delhi, India
  • Gyan Saurabh Department of Surgery, Lady Hardinge Medical College, New Delhi, India
  • Ranvir Singh Department of Surgery, Lady Hardinge Medical College, New Delhi, India



Breast cancer, RCC, Dual malignancy, Synchronous tumours, Metachronous tumours


Synchronous breast and kidney carcinomas are extremely rare with only 11 cases have been reported in the literature so far in the world. We present a case of a 40-year-old lady diagnosed with right invasive ductal cell carcinoma. During the workup of the patient, an incidental renal mass was identified. After appropriate investigations, the patient underwent a right modified radical mastectomy with a right partial nephrectomy. The patient recovered successfully and was put on regular follow-up post-discharge. We are reporting a case of synchronous presentation of carcinoma breast with RCC which is rare since in world literature, most of the multiple malignancies reported are metastasis/metachronous breast carcinoma with RCC. The aetiology of synchronous malignancy is complex, some primary tumours may not be symptomatic and detected in the routine metastatic workup, and this poses a challenge for the surgical team. Hence with the histopathological report and with the other clinical and radiological parameters, we made a final diagnosis of carcinoma right breast pT2N0M0 with synchronous renal cell carcinoma (RCC) pT1aN0M0. the patient was planned for adjuvant chemotherapy and advised regular follow-up.


Lv M, Zhang X, Shen Y, Wang F, Yang J, Wang B, et al. Clinical analysis and prognosis of synchronous and metachronous multiple primary malignant tumours. Medicine. 2017;96(17):e6799.

International Agency for Research on Cancer. India Source: Globocan 2020. Available at: Accessed on 11 January, 2023.

Demandante CGN, Troyer DA, Miles TP. Multiple primary malignant neoplasms: case report and a comprehensive review of the literature. Am J Clin Oncol. 2003;26(1):79-83.

Vogt A, Schmid S, Heinimann K, Frick H, Herrmann C, Cerny T et al. Multiple primary tumours: challenges and approaches, a review. ESMO Open. 2017;2(2):e000172.

Johnson CH, Peace S, Adamo P, Fritz A, Percy-Laurry A, Edwards BK. The 2007 multiple primary and histology coding rules. National Cancer Institute, Surveillance, Epidemiology and End Results Program. Bethesda. 2007.

Tanjak P, Suktitipat B, Vorasan N, Juengwiwattanakitti P, Thiengtrong B, Songjang C, et al. Risks and cancer associations of metachronous and synchronous multiple primary cancers: a 25-year retrospective study. BMC Cancer. 2021;21(1):1045.

Second cancers: developing a new cancer after breast cancer. Available at: cancer/breast-cancer/living-as-a-breast-cancer-survivor/second-cancers-after-breast-cancer.html. Accessed on 18 April, 2023.

Beisland C, Talleraas O, Bakke A, Norstein J. Multiple primary malignancies in patients with renal cell carcinoma: a national population-based cohort study. BJU Int. 2006;97(4):698-702.

Abdel-Rahman O. Risk of subsequent primary kidney cancer after another malignancy: a population-based study. Clinical Genitourinary Cancer. 2017;15(5):e747-54.

Sato S, Shinohara N, Suzuki S, Harabayashi T, Koyanagi T. Multiple primary malignancies in Japanese patients with renal cell carcinoma. Int J Urol. 2004;11(5):269-75.

Sarma M, Borde C, Subramanyam P, Shanmuga Sundaram P. Random synchronous malignancy in the male breast: a case report. J Breast Cancer. 2013;16(4):442-6.

Chakraborty S, Tarantolo SR, Batra SK, Hauke RJ. Incidence and prognostic significance of second primary cancers in renal cell carcinoma. Am J Clin Oncol. 2013;36(2):132.

Chen J, Lou J, He Y, Zhu Z, Zhu S. A comprehensive analysis of renal cell carcinoma as first and second primary cancers. World J Surgical Oncol. 2022;20(1):57.






Case Reports