Role of cadexomer iodine ointment as debriding agent in 50 cases of skin and soft tissue infections
Keywords:Cadexomer iodine, Venous leg ulcers, Postoperative infected wounds, Infected traumatic wounds, Ulcers with slough, Controlled diabetic wounds
Background: The management of skin and soft tissue infections is a tedious job to tackle as many factors play important roles in wound healing. Wounds can be better managed and healed faster if infection is removed and the way to eliminate infection is by use of antiseptics, antibiotics and solutions over wounds along with the use of systemic antibiotics. In this study, we used cadexomer iodine ointment for management of various types of wounds.
Methods: This study was conducted in a tertiary care hospital. After screening, 50 patients with various types of wounds (venous leg ulcers, postoperative infected wounds, infected traumatic wounds, controlled diabetic wounds, ulcers with slough, abscesses left for healing by secondary intention after operation) were taken and cadexomer iodine was applied when the wound was infected and had visible slough with pus discharge.
Results: Majority of the patients (about 88%) were free of visible slough in about a week and in about two weeks, all patients (100%) were free from visible slough. 74% patients have complete closure of the wound and 22% patients have reduction in total wound surface area between 75-99% in 4 weeks period.
Conclusions: Under controlled conditions, cadexomer iodine is a good topical agent for debridement of wounds which are infected and have a visible slough along with pus discharge. It also helps in healing the wound.
Swartz MN. Clinical practice. Cellulitis. N Engl J Med. 2004;350:904-12.
Angel DE, Morey P, Storer J, Mwipatayi BP. The great debate over iodine in wound care continues: a review of the literature. Wound Pract Res J Austral Wound Manage Assoc. 2008;16(1):6-21.
Zhou LH, Nahm WK, Badiavas E, Yufit T, Falanga V. Slow release iodine preparation and wound healing:in vitro effects consistent with lack of in vivo toxicity in human chronic wounds. Br J Dermatol. 2002;146(3):365-74.
Miller C. Examining the efficacy of silver and cadexomer iodine dressings in treating wounds compromised by bacterial burden: A review of the literature. Mendez-Vilas A, Science against microbial pathogens: communicating current research and technological advances. Formatex Res Centre. 2011;1:14-22.
Murdoch R, Lagan K. The role of povidine and cadexomer iodine in the management of acute and chronic wounds. Phys Ther Rev. 2013;18(3):207-16.
Frykberg RG, Banks J. Challenges in the treatent of chronic wound adv wound care. New Rochelle. 2015;4(9):560-82.
Rhoads DD, Wolcott RD, Percival SL, Biofilms in wounds: management strategies. J Wound Care. 2008;17:5028.
Gupta S, Shinde RK, Shinde S. Comparison of the outcomes of cadexomer iodine and povidone-iodine ointments in wound management. Cureus. 2022;14(5).
Woo K, Dowsett C, Costa B, Ebohon S, Woodmansey EJ, Malone M. Efficacy of topical cadexomer iodine treatment in chronic wounds: Systematic review and meta‐analysis of comparative clinical trials. Int Wound J. 2021;18(5):586-97.
Hansson C. The effects of cadexomer iodine paste in the treatment of venous leg ulcers compared with hydrocolloid dressing and paraffin gauze dressing. Cadexomer Iodine Study Group. Int J Dermatol. 1998;37:390-6.
Soriano JV. Chronic wounds treated with iodinated cadexomer. Study of a series of clinical cases with Iodosorb. Revista de enfermeria (Barcelona, Spain). 2010;33(11):38-42.
Malone M, Johani K, Jensen SO, Gosbell IB, Dickson HG, McLennan S, et al. Effect of cadexomer iodine on the microbial load and diversity of chronic non-healing diabetic foot ulcers complicated by biofilm in vivo. J Antimicrob Chemother. 2017;72(7):2093-101.
Fitzgerald DJ, Renick PJ, Forrest EC, Tetens SP, Earnest DN, McMillan J, et al. Cadexomer iodine provides superior efficacy against bacterial wound biofilms in vitro and in vivo. Wound Rep Regenerat. 2017;25(1):13-24.
Laudanska H, Gustavson B. In-patient treatment of chronic varicose venous ulcers. A randomized trial of cadexomer iodine versus standard dressings. J Int Med Res. 1988;16(6):428-35.
Holloway GA, Johansen KH, Barnes RW, Pierce GE. Multicenter trial of cadexomer iodine to treat venous stasis ulcer. West J Med. 1989;151(1):35.
Raju R, Kethavath SN, Sangavarapu SM, Kanjarla P. Efficacy of cadexomer iodine in the treatment of chronic ulcers: a randomized, multicenter, controlled trial. Wounds Compend Clin Res Pract. 2019;31(3):85-90.