A rare case of rectal gastrointestinal stromal tumour: diagnosis and management

Authors

  • Atish N. Bansod Department of Surgery, Indira Gandhi Medical College and Hospital, Nagpur, Maharashtra, India
  • Vaishnavpriya K. Jadhav Department of Surgery, Indira Gandhi Medical College and Hospital, Nagpur, Maharashtra, India
  • Rohan K. Umalkar Department of Surgery, Indira Gandhi Medical College and Hospital, Nagpur, Maharashtra, India
  • Abhijit M. Wankhede Department of Surgery, Indira Gandhi Medical College and Hospital, Nagpur, Maharashtra, India
  • Kathan M. Kothari Department of Surgery, Indira Gandhi Medical College and Hospital, Nagpur, Maharashtra, India

DOI:

https://doi.org/10.18203/2349-2902.isj20223615

Keywords:

Gastrointestinal stromal tumors, Imatinib, Rectal mass, KIT mutation

Abstract

Gastrointestinal stromal tumours are frequently defined as KIT-(CD117) or PDGFRA-positive mesenchymal spindle cell tumors. Gastrointestinal stromal tumors most commonly occur in the stomach and small intestine, with up to 5% of GISTs occurring in the colon and rectum. We presented a case of distal rectal GIST diagnosed by colonoscopy, colonoscopy with biopsy, computed tomography. The patient underwent Abdominoperineal resection (APR) and was confirmed on histopathology to have rectal GIST with tumor size more than 5 cm and mitotic rate more than 5/50 high power field (HPF). All GISTs are considered to have malignant potential, and, for that reason, all rectal GISTs should be considered for resection.

Author Biographies

Vaishnavpriya K. Jadhav, Department of Surgery, Indira Gandhi Medical College and Hospital, Nagpur, Maharashtra, India

JUNIOR RESIDENT, DEPARTMENT OF GENERAL SURGERY.

Rohan K. Umalkar, Department of Surgery, Indira Gandhi Medical College and Hospital, Nagpur, Maharashtra, India

ASSISTANT PROFESSOR, DEPARTMENT OF GENERAL SURGERY.

Abhijit M. Wankhede, Department of Surgery, Indira Gandhi Medical College and Hospital, Nagpur, Maharashtra, India

JUNIOR RESIDENT, DEPARTMENT OF GENERAL SURGERY.

Kathan M. Kothari, Department of Surgery, Indira Gandhi Medical College and Hospital, Nagpur, Maharashtra, India

JUNIOR RESIDENT, DEPARTMENT OF GENERAL SURGERY.

References

Miettinen M, Sarlomo-Rikala M, Lasota J. Gastrointestinal stromal tumours. Ann Chir Gynaecol. 1998;87(4):278-81.

Miettinen M, Furlong M, Sarlomo-Rikala M, Burke A, Sobin LH, Lasota J. Gastrointestinal stromal tumors, intramural leiomyomas, and leiomyosarcomas in the rectum and anus: a clinicopathologic, immunohistochemical, and molecular genetic study of 144 cases. Am J Surg Pathol. 2001;25(9):1121-33.

Tran T, Davila JA, El-Serag HB. The epidemiology of malignant gastrointestinal stromal tumors: an analysis of 1,458 cases from 1992 to 2000. Am J Gastroenterol. 2005;100(1):162-8.

Scarpa M, Bertin M, Ruffolo C, Polese L, D'Amico DF, Angriman I. A systematic review on the clinical diagnosis of gastrointestinal stromal tumors. J Surg Oncol. 2008;98(5):384-92.

Miettinen M, Majidi M, Lasota J. Pathology and diagnostic criteria of gastrointestinal stromal tumors (GISTs): a review. Eur J Cancer. 2002:S39-51.

Abbeele AD. The lessons of GIST--PET and PET/CT: a new paradigm for imaging. Oncologist. 2008;13(2):8-13.

Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 2010;17(6):1471-4.

Liu H, Yan Z, Liao G, Yin H. Treatment strategy of rectal gastrointestinal stromal tumor (GIST). J Surg Oncol. 2014;109(7):708-13.

Cavnar MJ, Wang L, Balachandran VP, Antonescu CR, Tap WD, Keohan M, et al. Rectal Gastrointestinal Stromal Tumor (GIST) in the Era of Imatinib: Organ Preservation and Improved Oncologic Outcome. Ann Surg Oncol. 2017;24(13):3972-80.

Jakob J, Mussi C, Ronellenfitsch U, Wardelmann E, Negri T, Gronchi A, et al. Gastrointestinal stromal tumor of the rectum: results of surgical and multimodality therapy in the era of imatinib. Ann Surg Oncol. 2013;20(2):586-92.

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Published

2022-12-30

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Section

Case Reports