Giant gastrointestinal stromal tumor of ileum: the gist of GIST: a case report

M. S. Ray; B. S. Deepak

doi:10.18203/2349-2902.isj20170868

Authors

M. S. Ray Department of Surgery, Military Hospital, Jalandhar Cantt., Jalandhar, Punjab, India
B. S. Deepak Department of Surgery, Military Hospital, Jalandhar Cantt., Jalandhar, Punjab, India http://orcid.org/0000-0001-7023-6789

DOI:

https://doi.org/10.18203/2349-2902.isj20170868

Keywords:

GIST, Small intestine-ileum

Abstract

Gastrointestinal stromal tumors (GIST) are relatively rare pathology as compared with other mitotic lesions of GIT. However, GIST is the most common mesenchymal neoplasms of the gastrointestinal tract. Biopsy of the lesion and Immuno-Histo-Chemistry (IHC) for CD117 confirms the diagnosis. Surgery remains the standard of care and only potentially curative therapy for patients with primary, resectable, localized gastrointestinal stromal tumor. However, chemotherapy with Imatinib is added in neoadjuvant or adjuvant form according to clinical situation, and histopathological status of the lesion.

Metrics

Metrics Loading ...

Author Biographies

M. S. Ray, Department of Surgery, Military Hospital, Jalandhar Cantt., Jalandhar, Punjab, India

Dr. M S Ray, MBBS, MS (General Surgery), Long term training in Gastro-Intestinal Surgery (AIIMS-New Delhi)

B. S. Deepak, Department of Surgery, Military Hospital, Jalandhar Cantt., Jalandhar, Punjab, India

DR DEEPAK B S, MRCS ENG, MS (GENERAL SURGERY), DNB (GENERAL SURGERY), MNAMS, FIMS, FACS

References

Mucciarini C, Rosi G, Bertolini F, Valli R, Cirilli C, Rashid I. Incidence and clinicopathologic features of gastrointestinal stromal tumors. A population- based study. BMC Cancer. 2007;7(230):1-7.

Miettinen M, Furlong M, Sarlomo-Rikala M, Burke A, Sobin LH, Lasota J. Gastrointestinal stromal tumors, intramural leiomyomas and leiomyosarcomas in the rectum and anus: a clinicopathologichistochemical and molecular genetic study of 144 cases. Am J Surg Path. 2001;25(9):1121-33.

Reith JD, Goldblum JR, Lyles RH, Weiss SW: Extragastrointestinal (soft issue) stromal tumors: an analysis of 48 cases with emphasis on histologic predictors of outcome. Mod Pathol. 2000;13(5):577- 85.

Miettinen M, Sarlomo-Rikala M, Lasota J. Gastrointestinal stromal tumors: recent advances in understanding of their biology. Hum Pathol. 1999;30:1213-20.

Isimbaldi G, Santangelo M, Cenacchi G. Gastrointestinal autonomic nerve tumor (plexosarcoma): report of a case with fine needle aspiration biopsy and histologic, immunocytochemical and ultrastructural study. Acta Cytol. 1998;42:1189-94.

Raut C, Dematteo R. Evidence-Guided surgical management of GIST: beyond a simple case of benign and malignant. Ann Surg Onc. 2008;15(5):1542.

Boggino HE, Fernandez MP, Logrono RF. Cytomorphology of gastrointestinal stromal tumor: diagnostic role of aspiration cytology, core biopsy, and immunochemistry. Diagn Cytopathol. 2000;23:156-60.

De Matteo RP, Lewis JJ, Leung D, Mudan SS, Woodriff JM, Brennan MF. Two hundred gastro-intestinal stromal tumors: recurrence patterns and prognostic factors for survival. Ann Surg. 2000;231:51- 8.

Dodd LG, Nelson RC, Mooney EE, Gottfried M. Fine-needle aspiration of gastrointestinal stromal tumors. Am J Clin Pathol. 1998;109:439-43.

Mehta RM, Vayoth OS, John AK, Nandakumar RR, Dhar PS, Sudhindran S, et al. Spontaneous rupture of giant gastric stromal tumor into gastric lumen. World J Surg Oncol. 2005;3(11):1477-8.

Li SQ, O’Leary TJ, Buchner SB. Fine needle aspiration of gastrointestinal stromal tumors. Acta Cytol. 2001;45:9-17.

Dong Q, McKee G, Pitman M, Geisinger K, Tambouret R. Epithelioid variant of gastrointestinal stromal tumor: diagnosis by fine-needle aspiration. Diagn Cytopathol. 2003;29:55-60.

Nauert TC, Zornoza J, Ordonez N. Gastric leiomyosarcoma. AJR Am J Roentgenol. 1982;139:291-7.

Miettinen M, El-Rifai W, Sobin LH, Lasota J. Evaluation of malignancy and prognosis of gastrointestinal stromal tumors: a review. Hum Pathol. 2002;33:478-83.

Pidhorecky I, Cheney RT, Kraybill WG, Gibbs JF: Gastrointestinal stromal tumors: current diagnosis, biologic behavior, and management. Ann Surg Oncol. 2000;7(9):705-12.

Nguyen SQ, Divino CM, Wang JL, Dikman SH. Laparoscopic management of gastrointestinal stromal tumors. Surg Endosc. 2006;20(5):713-6.

Lee CH, Hyun MH, Kwon YJ, Cho SI, Park SS. Deciding laparoscopic approaches for wedge resection in gastric submucosal tumors: a suggestive flow chart using three major determinants. J Am Coll Surg. 2012;215(6):831-40.