Metaplastic carcinoma of the breast: a case report
Keywords:Metaplastic breast carcinoma, Spindle cell, Breast carcinoma
Metaplastic carcinoma is a rare but heterogeneous group of neoplasm of breast, accounting for about 1% of all breast carcinomas. Metaplastic carcinomas may be either low-grade tumors (e.g., adenosquamous carcinoma or spindle cell carcinoma), or high-grade tumors (e.g., squamous cell carcinoma, or spindle cell carcinoma). We report a case of metaplastic breast carcinoma in a 72-year-old lady. The clinical, radiological and histological characteristics are discussed.
Pezzi CM, Patel-Parekh L, Cole K, Franko J, Klimberg VS, Bland K. Characteristics and treatment of metaplastic breast cancer: analysis of 892 cases from the National Cancer Data Base. Ann Surg Oncol. 2007;14(1):166-73.
Sinn H-P, Kreipe H. A brief overview of the WHO classification of breast tumors. 4th Edition, Focusing on Issues and Updates from the 3rd Edition Breast Care Basel Switz. 2013;8(2):149-54.
Carter MR, Hornick JL, Lester S, Fletcher CDM. Spindle cell (sarcomatoid) carcinoma of the breast: a clinicopathologic and immunohistochemical analysis of 29 cases. Am J Surg Pathol. 2006;30(3):300-9.
Luini A, Aguilar M, Gatti G, Fasani R, Botteri E, Brito JAD et al. Metaplastic carcinoma of the breast, an unusual disease with worse prognosis: the experience of the European Institute of Oncology and review of the literature. Breast Canc Res Treat. 2007;101(3):349-53.
Khan HN, Wyld L, Dunne B, Lee AHS, Pinder SE, Evans AJ et al. Spindle cell carcinoma of the breast: a case series of a rare histological subtype. Eur J Surg Oncol J Eur Soc Surg Oncol Br Assoc Surg Oncol. 2003;29(7):600-3.
Wargotz ES, Deos PH, Norris HJ. Metaplastic carcinomas of the breast. II. Spindle cell carcinoma. Hum Pathol. 1989;20(8):732-40.
Lee AHS. Recent developments in the histological diagnosis of spindle cell carcinoma, fibromatosis and phyllodes tumour of the breast. Histopathology. 2008;52(1):45-57.
Adem C, Reynolds C, Ingle JN, Nascimento AG. Primary breast sarcoma: clinicopathologic series from the Mayo Clinic and review of the literature. Br J Canc. 2004;91(2):237-41.
Drekolias D, Mamounas EP. Metaplastic breast carcinoma: current therapeutic approaches and novel targeted therapies. Breast J. 2019;25(6):1192-7.