Published: 2022-09-28

Gallbladder metastasis from primary renal malignancy: case report and review

Sai Sri Harsha, Shadan Ali, Ankita Singh, Lalit Aggarwal, Ashok Kumar, Anil Choudhary, Mansi Bansal


Gallbladder metastases are rare, that too from a renal malignancy are further rare. Renal cell carcinoma (RCC) accounts for 3% of adult malignancies and >30% of cases are already metastatic by the time of presentation. Neither gallbladder is a usual site for RCC to metastasize nor is clear cell RCC common in gallbladder secondaries. We report one such case of a 50-year-old man who was incidentally diagnosed to have left sided renal cell carcinoma and developed gallbladder and lung metastases detected in follow-up imaging. Patient underwent radical nephrectomy followed by extended cholecystectomy later on. And presently is receiving targeted therapy for pulmonary metastases.


Gallbladder, Metastatic, Renal cell carcinoma, Synchronous

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Maldazys JD, deKernion JB. Prognostic factors in metastatic renal carcinoma. J Urol. 1986;136(2):376-9.

Coşkun F, Cetinkaya M, Cengiz O, Adsan O, Kulaçoğlu S, Eroğlu A. Metastatic carcinoma of the gallbladder due to renal cell carcinoma in the ectopic kidney. Acta Chir Belg. 1995;95(1):56-8.

Chung PH, Srinivasan R, Linehan WM, Pinto PA, Bratslavsky G. Renal cell carcinoma with metastases to the gallbladder: four cases from the National Cancer Institute (NCI) and review of the literature. Urol Oncol. 2012;30(4):476-81.

Neves M, Neofytou K, Giakoustidis A, Hazell S, Wotherspoon A, Gore M, et al. Two cases of gallbladder metastasis from renal cell carcinoma and review of literature. World J Surg Oncol. 2016;14:87.

Shyr BU, Chen SC, Shyr YM, Lee RC, Wang SE. Metastatic polyp of the gallbladder from renal cell carcinoma. BMC Cancer. 2017;17(1):244.

Ueda I, Aoki T, Oki H, Takahashi H, Hayashida Y, Minagawa N, et al. Gallbladder metastasis from renal cell carcinoma: a case report with review of the literature. Magn Reson Med Sci. 2015;14(2):133-8.

Ruiz C, Pedrazzoli C, Bonacini S. Gallbladder's clear cell renal carcinoma metastasis: A case report. Int J Surg Case Rep. 2016;18:48-51.

Takagi K, Kawase K, Minoshima K, Yamaha M, Maekawa Y, Yokoi S, et al. Gallbladder metastasis from renal cell carcinoma: A case report and literature review. Urol Case Rep. 2019;23:69-71.

Heng DY, Kollmannsberger C, Chi KN. Targeted therapy for metastatic renal cell carcinoma: current treatment and future directions. Ther Adv Med Oncol. 2010;2(1):39-49.