DOI: http://dx.doi.org/10.18203/2349-2902.isj20221907

Diagnosis of metachronous papillary thyroid cancer with elevated carcino-embryonic antigen levels in tracking rectal carcinoma

Karikal Chakaravarthi, Amudhan Anbalagan, Jeswanth Satyanesan

Abstract


Carcinoembryonic antigen (CEA) is a tumor marker that is mostly used to track patients with colorectal cancer (CRC). CEA is an indirect tumor marker that can be useful in both malignant and benign diseases. We presented the case of a 49-year-old man who had been monitored for a lower rectal adenocarcinoma since 2010. In 2010, he had an abdominoperineal resection. Previously completed both neoadjuvant and adjuvant chemo-radiotherapy. In 2019, he was planned to undergo parastomal hernia (PS) repair, but studies have shown elevated CEA levels. The CEA concentration was 27.6 ng/ml. Although there were no signs of recurrence, positron emission tomography (PET) and computed tomography (PET/CT) revealed considerable uptake in the left lobar thyroid. Papillary thyroid carcinoma (PCT) was found on fine needle aspiration cytology (FNAc). He underwent total thyroidectomy and CEA level reached the baseline after thyroidectomy.

 


Keywords


Carcinoembryonic antigen, Carcinoma colo-rectum, Papillary carcinoma thyroid

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References


Benchimol S, Fuks A, Jothy S, Beauchemin N, Shirota K, Stanners CP. Carcinoembryonic Antigen, a Human Tumor Marker, Functions as an Intercellular Adhesion Molecule. Cell. 1989;57:327-34.

Nicholson BD, Shinkins B, Pathiraja I, Roberts NW, James TJ, Mallett S, et al. Blood CEA Levels for Detecting Recurrent Colorectal Cancer. Cochrane Database Syst Rev. 2015;CD011134.

Argilés G, Tabernero J, Labianca R, Hochhauser D, Salazar R, Iveson T, et al. Localised Colon Cancer: ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-Up. Ann Oncol. 2020;31:1291-305.

Van Cutsem E, Cervantes A, Nordlinger B, Arnold D. Metastatic Colorectal Cancer: ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-Up†. Ann Oncol. 2014;25:31-9.

Gold P, Freedman SO. Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J Exp Med. 1965;121:439-62.

Cimitan M, Busnardo B, Girelli ME, Casara D, Zanatta GP. Carcinoembryonic antigen in thyroid cancer. J Endocrinol Investig. 1979;2(3):241-4.