DOI: https://dx.doi.org/10.18203/2349-2902.isj20221166
Published: 2022-04-26

Abdominal wall metastasis and hyponatremia in metastatic renal cell carcinoma

Mansi Bansal, Ashok Kumar, Anup Mohta, Lalit Aggarwal, Shadan Ali

Abstract


Renal cell carcinoma (RCC) is a frequently encountered urological malignancy. It accounts for 2% to 3% of all adult malignant neoplasms, and usually carries a poor prognosis. About one third of patients with RCCs have distant metastases at the time of diagnosis and in one fourth, metastasis occurs despite radical nephrectomy. The most frequent sites of metastasis include lung (50-75%), bone (30-40%), liver (30-40%), brain and thyroid (25%). Subcutaneous metastases are uncommon, with very few reported cases and typically imply a poor prognosis (3.4% incidence). Hyponatremia is a poor prognostic marker in malignancy and is rarely associated with RCC. We report a case of metastatic anterior abdominal wall nodules and hyponatremia in a 65 years old gentleman diagnosed with left renal cell carcinoma.


Keywords


Abdominal wall metastasis, Hyponatremia, Renal cell carcinoma

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References


O'Connell PR, McCaskie AW, Williams NS. Kidneys and ureters. Bailey and love. 27th edition. 2018;1416.

Flanigan RC, Campbell SC, Clark JI. Metastatic renal cell carcinoma. Curr Treat Options Oncol. 2003;4:385-90.

Kumar S, Sharma P, Bera M. Isolated abdominal wall metastasis from renal cell carcinoma: Unusual presentation. Adv Biomed Res. 2015;4(1):65.

Dorairajan LN, Hemal AK, Aron M, Rajeev TP, Nair M, Seth A, Dogra PN, Gupta NP. Cutaneous metastases in renal cell carcinoma. Urol Int. 1999;63:164-7.

Peterson JL, McMarlin SL. Metastatic renal-cell carcinoma presenting as a cutaneous horn. J Dermatol Surg Oncol. 1983;9:815-8.

Mueller TJ, Wu H, Greenberg RE, Hudes G, Topham N, Lessin SR, et al. Cutaneous metastases from genitourinary malignancies. Urology. 2004;63:1021-6.

Jeppesen A, Jensen H, Donskov F, Marcussen N, von der Maase H. Hyponatremia as a prognostic and predictive factor in metastatic renal cell carcinoma. Br J Cancer. 2010;102(5):867-72.

Nyanti L, Samsudin A, Tiong I. Syndrome of inappropriate antidiuretic hormone secretion and Leser–Trélat syndrome as uncommon paraneoplastic manifestations of renal malignancy – a geriatric experience: a case report. J Med Case Rep. 2019;13(1).