Total serum calcium and corrected calcium as severity predictors in acute pancreatitis: a prospective study in a tertiary hospital in South India

Unnikrishnan Edakkepuram; Muhammad Navas N. K.; Sasi M. Parambil; Siddharth Matad

doi:10.18203/2349-2902.isj20164848

Authors

Unnikrishnan Edakkepuram Department of Surgery, Government Medical College, Kozhikode, Kerala, India
Muhammad Navas N. K. Department of Surgery, Government Medical College, Kozhikode, Kerala, India
Sasi M. Parambil Department of Surgery, Government Medical College, Kozhikode, Kerala, India
Siddharth Matad Department of Surgery, Government Medical College, Kozhikode, Kerala, India

DOI:

https://doi.org/10.18203/2349-2902.isj20164848

Keywords:

Albumin corrected calcium, BISAP, Serum calcium

Abstract

Background: Acute pancreatitis still remains a disease of growing burden to mankind; it is an unpredictable, potentially lethal disease with a high mortality. The incidence of acute Pancreatitis appears to be increasing. Aim of the study was to evaluate total serum calcium and corrected calcium as prognostic severity factors in acute pancreatitis.

Methods: This prospective study was conducted in a tertiary hospital from July2015 to June 2016. All the patients who were diagnosed to have acute pancreatitis by clinical examination, laboratory, radiological and biochemical investigations were considered as cases. Serum calcium and albumin corrected calcium measured within 24 hours of admission. Patients followed up for a maximum period of 4 weeks and outcome studied, in terms of whether patient had local or systemic complication, mortality. Significance of serum calcium and albumin corrected calcium in predicting outcome of acute pancreatitis is assessed and compared with BISAP score.

Results: Acute pancreatitis most commonly occurs in the age group of 30-50. 80% of acute pancreatitis occurs in male and 20% in female. Alcoholism accounts for 58% cases of acute pancreatitis and gall stone account for 28% of acute pancreatitis.

Conclusions: Hypocalcaemia and low ACC can predict severity of acute pancreatitis, as with BISAP score, but it is not superior to BISAP score.

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References

Frey CF, Zhou H, Harvey DJ, White RH. The Incidence and case fatality rates of acute biliary, alcoholic, and idiopathic pancreatitis in California. Pancreas 2006; 33(4):336-44.

Lowenfels AB, Maisonneuve P, Sullivan T. The changing character of acute pancreatitis: epidemiology, etiology, prognosis. Current Gastroenterology Reports. 2009;11(2):97-103.

Balthazar EJ. Acute pancreatitis: assessment of severity with clinical and CT evaluation. Radiology. 2002;223(3):603-13.

Knaus WA, Draper EA, Wagner DP. APACHE II: A severity of disease classification system. Crit Care Med. 1985;13:818-29.

Carroll JK, Herrick B, Gipson T. Acute pancreatitis: diagnosis, prognosis, and treatment. Am Fam Physician. 2007;75:1513-20.

Hong W, Dong L, Huang Q, Wu W, Wu J, Wang Y. Prediction of severe acute pancreatitis using classification and regression tree analysis. Digestive Dis Sci. 2011; 56(11):3664-671.

Lee BJ, Kim CD, Jung SW. Analysis of the factors that affect the mortality rate in severe acute pancreatitis. Korean J Gastroenterol. 2008;51:25-33.

Shinzeki M, Ueda T, Takeyama Y. Prediction of early death in severe acute pancreatitis. J Gastroenterol. 2008;43:152-8.

Sun B, Li HL, Gao Y. Factors predisposing to severe acute pancreatitis: evaluation and prevention. World J Gastroenterol. 2003;9:1102-5.

Ammori BJ, Barclay GR, Larvin M. Hypocalcemia in patients with acute pancreatitis: a putative role for systemic endotoxin exposure. Pancreas. 2003;26:213-7.

Gurda A, Kusnierz B, Nowak W. Assessment of the prognostic value of certain acute-phase proteins and procalcitonin in the prognosis of acute pancreatitis. Pancreas. 2008;37:449-53.

Sashidhar RB, Rajesh N. A study of epidemiology and clinical profile of acute pancreatitis in a tertiary hospital in south India. Int J Scientific Research. 2015; 4(12):28-30.

Jiménez AA, Jimenez CE, Córdoba LR. Total serum calcium and corrected calcium as severity predictors in acute pancreatitis. Revista de Gastroenterología de México 2014; 79(1):13-21.

Chen L, Guomin L, Qunyan Z, Qiang Z. Evaluation of the BISAP score in predicting severity and prognoses of acute pancreatitis in chinese patients. Int Surg. 2013;98(1):6-12.