Immunohistochemical profile of carcinoma breast and its association with clinicopathological features: a single institutional experience
Keywords:Breast cancer, Hormone receptor, HER 2neu, IHC
Background: Breast cancer is a systemic disease which has different biological subtypes with vast natural history, clinical presentation, various pathological types and molecular features which has impact on prognostic profile and outcome. Present study aims to evaluate correlation of receptor status (ER, PR and HER 2neu) with other tumor characteristics.
Methods: The present study was a prospective observational study of 50 breast cancer patients and was conducted from January 2020 to June 2021 in surgical unit of the department of general surgery at MDM hospital attached with Dr. S. N. medical college, Jodhpur, Rajasthan.
Results: Most common age group was 41-50 years in 38% cases. Majority of patients were females (49, 98%). The 88% cases had invasive duct carcinoma. ER, PR and HER 2neu positivity had statistically significant correlation with age (p<0.0001), histological grade (p<0.0001) and tumor size (p=0.04). HER 2neu had statistically significant negative correlation with ER and PR (p<0.05).
Conclusions: Immunohistochemistry (IHC) markers (ER, PR, HER 2neu) are positively correlated with increasing age, tumor size, tumor grade and positive axillary lymph nodes, also there is statistically significant correlation between HER 2neu overexpression and hormone receptor (ER, PR) negativity in study population.
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