DOI: http://dx.doi.org/10.18203/2349-2902.isj20220070

A tertiary care prospective of epidemiology and aetiopathogenesis of acute pancreatitis

Varun Dogra, Rabia Nazir Ahmed, Ishfaq Ahmad Gilkar, Irfan Ahmad Mir

Abstract


Background: Acute pancreatitis is a potentially lethal condition resulting from an acute inflammatory process in the pancreas usually manifested by upper abdominal pain and raised concentration of pancreatic enzymes in blood, urine and peritoneal fluid. Aims and objectives were to study the epidemiology and aetiopathogenesis of acute pancreatitis in Jammu region of Northern India.

Methods: This was a descriptive cross-sectional hospital based study, conducted in the postgraduate department of surgery, Government Medical College Jammu for a period of 3 years and included all admitted patients with diagnosis of acute pancreatitis. The main outcome variable was to find the various etiological factors associated with acute pancreatitis.

Results: In our study acute pancreatitis was found to be more common in younger people. Most of the patients in the study population were below 40 years of age. Majority of the patients presented first time to the hospital with the chief complaints of pain upper abdomen. In this study, we found that the two principal causes of acute pancreatitis in our population were gall stones and alcoholism which contributed a total of about 68% cases followed by other causes such as hyperlipidemia, drug induced pancreatitis, worm induced acute pancreatitis, post-surgical pancreatitis, post traumatic pancreatitis, and hypercalcemia.

Conclusions: Acute pancreatitis is a disease with high morbidity and mortality, and is quite common in Northern India. As such there is a need to make our population aware regarding the impact of alcoholism and bad dietary practices in causation of acute pancreatitis.


Keywords


Acute pancreatitits, Computed tomography, Serum amylase, Serum lipase

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References


De Beaux AC, Palmer KR, Carter DC. Factors influencing morbidity and mortality in acute pancreatitis; an analysis of 279 cases. Gut. 1995;37(1):121-6.

Banks PA. Acute pancreatitis: medical and surgical management. Am J Gastroenterol. 1994;89(8):78-85.

Yadav D, Lowenfels AB. The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology. 2013;144:1252-61.

Baig SJ, Rahed A, Sen S. A prospective study of the aetiology, severity and outcome of acute pancreatitis in Eastern India. Trop Gastroenterol. 2008;29(1):20-2.

Liu CL, Lo CM, Chan JK, Poon RT, Fan ST. EUS detection of occult cholelithiasis in patients with idiopathic pancreatitis. Gastrointest Endosc. 2000;51(1):28-32.

Mennecier D, Pons F, Arvers P, Corberand D, Sinayoko L, Harnois F, Moulin O, Thiolet C, Nizou C, Farret O. Incidence and severity of non-alcoholic and non-biliary pancreatitis in a gastroenterology department. Gastroenterol Clin Biol. 2007;31(8-9):664-7.

Shetty SK, Naik R, Adithi SS. Acute pancreatitis-The current concept in Etiopathogenesis, morphology and complications. J Clin Diagnost Res. 2018;12(3):15-7.

Banerjee I, Banerjee I, Das KN, Sathian B, Pugazhandhi B, Roy B, Banerjee SM, Khadka S. Etiological Factors of Non Alcohol Non Gallstone Related Acute Pancreatitis. Nepal J Epidemiol. 2014;4(3):351-62.

Baig SJ, Rahed A, Sen S. A prospective study of the aetiology, severity and outcome of acute pancreatitis in Eastern India. Trop Gastroenterol. 2008;29(1):20-2.

Chang MC, Su CH, Sun MS, Huang SC, Chiu CT, Chen MC, Lee KT, Lin CC, Lin JT. Etiology of acute pancreatitis – a multi-center study in Taiwan. Hepatogastroenterology. 2003;50(53):1655-7.

Raj SM, Lopez D, Thambidorai CR, Kandasamy P, Toufeeq Khan TF,Mohamad H, Mansur M, Aiyar S. Acute pancreatitis in north-eastern peninsular Malaysia: an unusual demographic and aetiological pattern. Singapore Med J. 1995;36(4):371-4.

Khuroo MS, Rather AA, Khuroo NS. Hepatobiliary and pancreatic Ascariasis. World J Gastroenterol. 2016;22(33):7507-17.

Garg PK, Tandon RK, Madan K. Is biliary microlithiasis a significant cause of idiopathic recurrent acute pancreatitis. Clin Gastroenterol Hepatol. 2007;5:75-9.

Lee SP, Nicholls JF, Park HZ. Biliary sludge as a cause of acute pancreatitis. N Engl J Med. 1992;326(9):589-93.

Agrawal A, Parikh M, Jasdanwala S. Non-Alcoholic Fatty Liver Disease as a Risk Factor for Acute Pancreatitis: A Case Control Study. Emerg Med (Los Angel). 2015;5:26.