Case report on post COVID-19 penile gangrene

Devashish Sharma; Shirish Mishra; Dilip Chaurasia

doi:10.18203/2349-2902.isj20220349

Authors

Devashish Sharma Department of Surgery, Motilal Nehru Medical College, Prayagraj, Uttar Pradesh, India
Shirish Mishra Department of Surgery and Urology, Motilal Nehru Medical College, Prayagraj, Uttar Pradesh, India
Dilip Chaurasia Department of Surgery and Urology, Motilal Nehru Medical College, Prayagraj, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2349-2902.isj20220349

Keywords:

COVID-19, Coagulapathy, Thrombogenesis, Gangrene

Abstract

SARS-CoV-2, a β-coronavirus, is a highly contagious respiratory pathogen that causes a disease. Penile Gangrene may be a rare manifestation in the post COVID-19 infection period in a non-vasculopathic patient. There may be an association with component of coagulopathy seen in COVID-19 patients. This case report describes a case with gangrene of penis in a young boy with concurrent COVID-19 infection. Clinical evaluation, investigation diagnostic workup and management of the patient was done in a routine basis. It was found that acute onset pain and blackening of his penis which developed after COVID-19 related symptoms in absence of any other identifiable cause. Unfortunately, the patient lost the involved body part and sustained a permanent disability. Early identification of such a morbid and disabling condition can help in preventing further spread of infection and may also prevent loss of organ or body part.

Metrics

Metrics Loading ...

Author Biographies

Devashish Sharma, Department of Surgery, Motilal Nehru Medical College, Prayagraj, Uttar Pradesh, India

Department of general surgery

Shirish Mishra, Department of Surgery and Urology, Motilal Nehru Medical College, Prayagraj, Uttar Pradesh, India

Department of Urology

Dilip Chaurasia, Department of Surgery and Urology, Motilal Nehru Medical College, Prayagraj, Uttar Pradesh, India

Department of urology

References

Meduri GU, Kohler G, Headley S, Tolley E, Stentz F, Postlethwaite A. Inflammatory cytokines in the BAL of patients with ARDS. Persistent elevation over time predicts poor outcome. Chest. 1995;108(5):1303-14.

Sriram K, Insel PA. Inflammation and thrombosis in COVID-19 pathophysiology: proteinase-activated and purinergic receptors as drivers and candidate therapeutic targets. Physiol Rev. 2021;101(2):545-67.

Gao THM, Zhang X, Li H, Zhu L. Highly pathogenic coronavirus N protein aggravates lung injury by MASP-2-mediated complement overactivation. medRxiv. 2020.

Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020;18(4):844-7.

Ciceri F, Beretta L, Scandroglio AM, Colombo S, Landoni G, Ruggeri A, et al. Microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome (MicroCLOTS): an atypical acute respiratory distress syndrome working hypothesis. Crit Care Resusc. 2020;22(2):95-7.

Magro C, Mulvey JJ, Berlin D, Nuovo G, Salvatore S, Harp J, et al. Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases. Transl Res. 2020;220:1-13.

Mondal S, Quintili AL, Karamchandani K, Bose S. Thromboembolic disease in COVID-19 patients: A brief narrative review. J Intensive Care. 2020;8:70.

Novara E, Molinaro E, Benedetti I, Bonometti R, Lauritano EC, Boverio R. Severe acute dried gangrene in COVID-19 infection: a case report. Eur Rev Med Pharmacol Sci. 2020;24(10):5769-71.

Chen Y, Klein SL, Garibaldi BT, Li H, Wu C, Osevala NM, et al. Aging in COVID-19: Vulnerability, immunity and intervention. Ageing Res Rev. 2021;65:101205.

Kappel C, Piticaru J, Jones G, Goucher G, Cheon P, Fischer M, et al. A case of possible Fournier's gangrene associated with proning in COVID-19 ARDS. Can J Anaesth. 2020;67(11):1697-8.