Pure squamous cell carcinoma of the gallbladder in a patient with perforated calculus cholecystitis


  • Alice V. Nicol Department of General Surgery, Ipswich Hospital, Ipswich, Queensland, Australia University of Queensland, Brisbane, Queensland, Australia
  • Jessica Y. S. N. Department of General Surgery, Ipswich Hospital, Ipswich, Queensland, Australia Griffith University, Gold Coast, Queensland, Australia
  • Rachel Colbran Department of General Surgery, Ipswich Hospital, Ipswich, Queensland, Australia University of Queensland, Brisbane, Queensland, Australia




Gallbladder carcinoma, Squamous cell carcinoma, Gallbladder malignancy


Gallbladder carcinoma is one of the most common and aggressive malignancies to arise from the biliary tract. However, pure squamous cell carcinoma (SCC) originating from the gallbladder is exceptionally rare, reported to represent less than 1% of all malignancies. An 89-year-old Australian male presented with symptoms and imaging consistent with acute calculus cholecystitis. After failed conservative management he underwent a subtotal cholecystectomy. Diagnosis on histopathological examination demonstrated SCC of the gallbladder. This case highlights the importance of considering gallbladder malignancy including rare histological subtypes such as SCC in patients presenting with symptoms consistent with benign gallbladder disease particularly in the elderly population.


Krishnatreya M, Kataki AC. Randomized-Control Screening Trials to Lower Gall Bladder Cancer Mortality in High Risk Populations. Asian Pac J Canc Prev. 2016;17(4):2325-7.

Duffy A, Capanu M, Abou-Alfa GK, Huitzil D, Jarnagin W, Fong Y, et al. Gallbladder cancer (GBC): 10-year experience at Memorial Sloan-Kettering Cancer Centre (MSKCC). J Surg Oncol. 2008;98(7):485-9.

Zhu AX, Hong TS, Hezel AF, Kooby D. Current management of gallbladder carcinoma. The Oncologist. 2010;15(2):168-81.

Emmett CD, Barrett P, Gilliam AD, Mitchell AI. Routine versus selective histological examination after cholecystectomy to exclude incidental gallbladder carcinoma. Ann Royal Coll Surg Engl. 2015;97(7):526-9.

Roa JC, Tapia O, Cakir A, Basturk O, Dursun N, Akdemir D et al. Squamous cell and adenosquamous carcinomas of the gallbladder: clinicopathological analysis of 34 cases identified in 606 carcinomas. Modern Pathol. 2011;24(8):1069-78.

Lada PE, Taborda B, Sanchez M, Tommasino J, Rosso FF, Gramatica L, et al. Adenosquamous and squamous carcinoma of the gallbladder. Cirugia espanola. 2007;81(4):202-6.

Hosseinzadeh M, Shokripur M, Salahi H. Primary pure squamous cell carcinoma of gallbladder presenting as acute cholecystitis. Iran J Med Sci. 2012;37(4):271-3.

Alpuerto AC, Mora ME, Robitsek RJ, Schubl SD. Primary Pure Squamous Cell Carcinoma of the Gallbladder Locally Invading the Liver, Duodenum, and Stomach: A Case Report and Literature Review. Case Rep Surg. 2017;2017:2534029.

Yildiz I, Koca YS, Barut I. Overlap of Acute Cholecystitis with Gallstones and Squamous Cell Carcinoma of the Gallbladder in an Elderly Patient. Case Rep Surg. 2015;767196.

Gulwani HV, Gupta S, Kaur S. Squamous Cell and Adenosquamous Carcinoma of Gall Bladder: a Clinicopathological Study of 8 Cases Isolated in 94 Cancers. Indian J Surg Oncol. 2017;8(4):560-6.






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