A clinical study on efficacy of peri-lesional autologous platelet-rich plasma in non-healing ulcers

Authors

  • Raghuveer Chakravarthy Gogineni Department of General Surgery, DR. PSIMS & RF, Gannavaram, Krishna district, Andhra Pradesh, India
  • Ratta Reddy Bommareddy Department of General Surgery, DR. PSIMS & RF, Gannavaram, Krishna district, Andhra Pradesh, India
  • Ede Naresh Babu Department of General Surgery, DR. PSIMS & RF, Gannavaram, Krishna district, Andhra Pradesh, India
  • Mayanam Subhashini Department of General Surgery, DR. PSIMS & RF, Gannavaram, Krishna district, Andhra Pradesh, India
  • Akula V. S. Jaya Krishnah Department of General Surgery, DR. PSIMS & RF, Gannavaram, Krishna district, Andhra Pradesh, India

DOI:

https://doi.org/10.18203/2349-2902.isj20220329

Keywords:

Platelet-rich plasma, PRP, Non-healing ulcers, Venous ulcers

Abstract

Background: Non-healing ulcers are a major health problem worldwide and have a great impact at personal, professional, and social levels. They are a major cause of non-traumatic lower limb amputations. The application of autologous Platelet Rich Plasma (PRP) has been a breakthrough in the treatment of non-healing ulcers, as it is an easy and cost-effective procedure, and provides the necessary growth factors that enhance tissue healing. The aim and objective of the study was to test the effectiveness of peri-ulcer autologous platelet-rich plasma injection in chronic non-healing ulcers and to assess the time taken for wound closure.

Methods: This study was conducted on 50 patients during the period of November 2020 to October 2021 from the in-patients of the surgical unit in Dr. PSIMS and RF. Autologous PRP was prepared from whole blood utilizing a rapid, point-of-care system that works on the principle of density gradient centrifugation. Fifty (50) patients with non-healing ulcers of different etiologies, who met the inclusion criteria, were treated with peri-ulcer autologous PRP injections once weekly.

Results: Of the 50 cases 29 were male and 21 were female, the mean age of the patients is 54.48±10.79 years. All the patients showed signs of wound healing with a reduction in wound size, and the mean time duration of ulcer healing was 6.75±1.47 weeks.

Conclusions: This prospective study has demonstrated the potential safety and efficacy of autologous platelet-rich plasma injection for the treatment of chronic non-healing ulcers.

Author Biographies

Raghuveer Chakravarthy Gogineni, Department of General Surgery, DR. PSIMS & RF, Gannavaram, Krishna district, Andhra Pradesh, India

Associate Professor, Department of General Surgery

Ratta Reddy Bommareddy, Department of General Surgery, DR. PSIMS & RF, Gannavaram, Krishna district, Andhra Pradesh, India

Associate Professor, Department of General Surgery

Ede Naresh Babu, Department of General Surgery, DR. PSIMS & RF, Gannavaram, Krishna district, Andhra Pradesh, India

Assistant Professor, Department of General Surgery

Mayanam Subhashini, Department of General Surgery, DR. PSIMS & RF, Gannavaram, Krishna district, Andhra Pradesh, India

Postgraduate, Department of General Surgery

Akula V. S. Jaya Krishnah, Department of General Surgery, DR. PSIMS & RF, Gannavaram, Krishna district, Andhra Pradesh, India

Postgraduate, Department of General Surgery

References

Sebastian KMS, Lobato I, Hernandez I. Efficacy and safety of autologous platelet rich plasma for the treatment of vascular ulcers in primary care: phase III study. BMC Fam Pract. 2014;15:211.

Greer N, Foman N, Dorrian J. Advanced wound care therapies for nonhealing diabetic, venous, and arterial ulcers: a systematic review. 2012;09-009.

Sheehan P, Jones P, Caselli A, Giurini JM, Veves AJD. Percent change in wound area of Diabetic foot ulcers over a four-week period is a robust predictor of complete healing in a twelve-week prospective trial. 2003;26(6):1879-82.

Robson MC, Barbul A. Guidelines for the best care of Chronic wounds. Wound repair and regeneration: official publication of the Wound Healing Society [and] the European Tissue Repair Society. 2006;14(6):647-8.

Aminian B SM, Karim-Agahee B, Soveyd M, Om Rani GR. The role of the autologous platelet-derived growth factor in the management of Decubitus ulcer. Arch Iranian Med. 1999;2:98-101.

Steed DL. Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity diabetic ulcer. Diabetic ulcer study group. Journal of vascular surgery. 1995;21(1):71-8.

Martinez-Zapata MJ, Marti–Carvajal CAJ, Sola I, Exposito JA, Bolibar I, Rodriguez L, et al. Autologous platelet-rich plasma for treating chronic wounds. The Cochrane database of systematic reviews. 2016;(5):Cd006899.

Driver VR, Hanft J, Fylling CP, Deriou JM. A prospective, randomized, controlled trial of autologous platelet-rich plasma gel for the treatment of diabetic foot ulcers. Ostomy/wound management. 2006;52(6):68-70.

Damir AJJ. Recent advances in management of chronic non-healing diabetic foot ulcers. 2011;24(4):2019-23.

Andia I, Abate MJR. Platelet-rich plasma: underlying biology and clinical corelates. 2013;8(5):645-58.

Li L, Chen D, Wang C. Autologous Platelet-rich gel for treatment of diabetic chronic refractory cutaneous ulcers: A prospective, randomized clinical trial. Wound repair and regeneration: official publication of the Wound Healing Society [and] the European Tissue Repair Society. 2015;23(4):495-505.

Ahmed M, Reffat SA. Platelet-rich plasma for the treatment of Clean Diabetic foot ulcers. Annals of vascular surgery. 2017;38:206-11.

Sakata J, Sasaki S. A retrospective, longitudinal study to evaluate healing lower extremity wounds in patients with dibetes mellitus and ischemia using standard protocols of care and platelet-rich plasma gel in a Japanese wound care program. Ostomy/wound management. 2012;58(4):36-49.

Yilmaz S, Aksoy E, Dogansi S. autologous platelet-rich plasma in treatment of chronic venous leg ulcers: A prospective case series. Vascular. 2015;23(6):580-5.

Stacey M, Mata SD, Trengove NJ, Mather CA. Randomised double-blind placebo-controlled trial of topical autologous platelet lysate in venous ulcer healing. European journal of vascular and endovascular surgery. The official journal of the Eurpoean Society for Vascular Surgery. 2000;20(3):296-301.

Crovetti G, Martinelli G, Issi M. Platelet gel for healing cutaneous chronic wounds. Transfusion and apheresis science: official journal of the World Apheresis Association. Official journal of the European Society for Haemapheresis. 2004;30(2):145-51.

Downloads

Published

2022-01-29

Issue

Section

Original Research Articles