Role of C-reactive protein in predicting the outcome of acute pancreatitis

Authors

  • Venkatesh S. Department of General Surgery, Rajarajeswari Medical College, Bangalore, Karnataka, India
  • Neetha V. Department of General Surgery, Rajarajeswari Medical College, Bangalore, Karnataka, India
  • Manish S. Department of General Surgery, Rajarajeswari Medical College, Bangalore, Karnataka, India
  • Krishnan P. B. Department of General Surgery, Rajarajeswari Medical College, Bangalore, Karnataka, India

DOI:

https://doi.org/10.18203/2349-2902.isj20215150

Keywords:

CRP, Pancreatitis, Serum enzymes

Abstract

Background: Acute pancreatitis is one of the most commonly encountered clinical entities in surgical practice and controversy still exists regarding the clinical features of acute pancreatitis. An early diagnosis, however, is regarded as mandatory for successful treatment. Over the years many Authors have proposed different scoring systems for the early assessment of the clinical evolution of acute pancreatitis. The most widely used scoring systems are often cumbersome and difficult to use in clinical practice because of their multi factorial nature. Thus, a number of unifactorial prognostic indices have been employed in routine hospital practice, such as C-reactive protein (CRP), serum amylase and serum lipase. These serum enzymes are easy to obtain in normal clinical practice and many authors consider them as reliable as multi factorial scoring systems.

Methods: A hospital based observational prospective study was done with 30 patients to measure C reactive protein levels in patients of acute pancreatitis and evaluate if CRP levels predict the severity of pancreatitis.

Results: In cases where CRP was raised >100 mg/dl on day 7 and beyond showed either a complication or increased duration of stay and delayed recovery. This correspondence of CRP with the clinical outcome co related well with other parameters like blood counts, serum lipase and amylase levels too.

Conclusions: Hence, CRP can be a very useful uni factorial tool in assessing and thereby predicting the outcome in a case of pancreatitis.

References

Whitcomb DC, Yadav D, Adam S. Multicenter approach to recurrent acute and chronic pancreatitis in the United States: the North American Pancreatitis Study 2 (NAPS2). Pancreatology. 2008;8(4-5):520-31.

Morinville VD, Barmada MM, Lowe ME. Increasing incidence of acute pancreatitis at an American pediatric tertiary care center: is greater awareness among physicians responsible?. Pancreas. 2010;39(1):5-8.

Whitcomb DC. Clinical practice. Acute pancreatitis. N Engl J Med. 2006;354(20):2142-50.

Thompson D, Pepsys MB, Wood SP. The physiological structure of human C- reactive protein and its complex with phosphocholine structure. 1999;7(2):169-77.

Lothar T. Labor and Diagnose TH-Brooks, Frankfurt. 2008;1010.

Gurleyik G, Emir S, Kilicoglu G, Arman A, Saglam A. Computed tomography severity index, APACHE II score and serum CRP concentration for predicting the severity of acute pancreatitis. JOP. 2005;6:562-7.

De la Peña J, De las Heras G, Peralta GF, Casafont F, Romero PF. Prospective study of the prognostic value of C reactive protein, alpha 1-antitrypsin and alpha 1-acid glycoprotein in acute pancreatitis. Rev Esp Enferm Dig. 1991;79:337-40.

Simona. Ann Gastroenterol. 2013;26(2):156-62.

Ranson JHC, Spenser FC. Prevention, diagnosis, and treatment of pancreatic abcess. Surgery. 1977;82:99-106.

Lowenfels, Maisonneuve P, Sullivan T. The changing character of acute pancreatitis: epidemiology, etiology, and prognosis. Curr Gastroenterol Rep. 2009;11:97-103.

Frossard JL, Steer ML. Pasto Acute pancreatitis Lancet. 2008;371:143-52.

Imrie CW. Prognosis of acute pancreatitis. Ann Ital Chir. 199;66:187-9.

Buter A, Imrie CW, Carter CR, Evans S, McKay CJ. Dynamic nature of pancreatitis early organ dysfunction determines outcome in acute pancreatitis. Br J Surg. 2002;89:298-302.

Larvin M, McMahon MJ. APACHE-II score for assessment and monitoring of acute. Lancet. 1989;2:201-20.

Mofidi R, Patil PV, Suttie SA, Park RW. Risk assessment in acute pancreatitis. Br J Surg. 2009;96:137-5.

Downloads

Published

2021-12-28

Issue

Section

Original Research Articles