Published: 2021-11-26

Histological surprise, mammary analogue secretory carcinoma of parotid gland

Iram T. Pasha, Akhila K., Ravikumar V., Sandeep Kumar


A recent described entity, mammary analogue secretary carcinoma (MASC) in 2010 by Skalova et al whose morphological and immunohistochemical features are similar in secretory carcinoma of the breast and salivary gland. This is a low-grade carcinoma which presents as a firm, slow-growing, circumscribed lesion with male preponderance. We present a case report of MASC.


Mammary analogue secretary carcinoma, MASC, Parotid gland, parotidectomy

Full Text:



Nisar Z, Pol JN, Jagdale RV, Phadke MD, Kadkol GA. Mammary analogue secretory carcinoma: An Indi. an experience of a novel entity. Indian J Pathol Microbiol 2020;63(S1):134-40.

Inaki R, Abe M, Zong L, Abe T, Shinozaki-Ushiku A, Ushiku T et al. Secretory carcinoma—impact of translocation and gene fusions on salivary gland tumor. Chinese Journal of Cancer Research. 2017;29(5):379.

Patel KR, Solomon IH, El-Mofty SK, Lewis JS, Chernock RD. Mammaglobin and S-100 protein immunoreactivity in salivary gland carcinomas other than mammary analogue secretory carcinoma. Hum Pathol. 2013;44:25018.

Skálová A, Vanecek T, Sima R, Laco J, Weinreb I, Perez-Ordonez B et al. Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity. Am J Surg Pathol. 2010;34:599-608.

Tognon CE, Somasiri AM, Evdokimova VE, Trigo G, Uy EE, Melnyk N et al. ETV6-NTRK3- mediated breast epithelial cell transformation is blocked by targeting the IGF1R signaling pathway. Cancer Res 2011;71:1060-70.

Chiosea SI, Griffith C, Assad A, Seethala RR. Clinicopathological characterization of mammary analogue carcinoma of salivary glands. Histopathology. 2012;61:387-94.

Skálová A, Vanecek T, Majewska H, Laco J, Grossmann P, Simpson RHW et al. Mammary analogue secretory carcinoma of salivary glands with high grade transformation: report of three cases with the ETV6- NTRK3 gene fusion and analysis of TP53, beta-catenin, EGFR and CCND1 genes. Am J Surg Pathol. 2011;38:23-33.

Taipale M, Krykbaeva I, Whitesell L, Santagata S, Zhang J, Liu Q et al. Chaperones as thermody- namic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells. Nat Biotechnol. 2013;31:630-7.