DOI: http://dx.doi.org/10.18203/2349-2902.isj20213972

Is serum phosphorous level an early indicator of post-operative hypocalcemia after total thyroidectomy? A prospective analysis

Antony P. Thachil, Carbin S. Joseph, Sandeep Kumar S. David

Abstract


Background: Total thyroidectomy is a commonly performed surgery. Postoperative hypocalcemia is a worrisome complication which can be treated if recognized early. We analysed serum phosphorous as a potential marker of postoperative hypocalcemia.

Methods: The study was a cross-sectional study done in our tertiary care hospital. We analysed the serum phosphorous levels of 50 patients who underwent total thyroidectomy at our institution. The incidence of hypocalcemia was documented and analysed with respect to serum phosphorous.

Results: In the study, 18 (36%) had hypocalcaemia on third postoperative day and 32 (64%) had no hypocalcaemia. There was no relation between post thyroidectomy day one serum phosphorus value and post-thyroidectomy day three serum calcium value (p=0.709).

Conclusions: The study did not find any statistically significant association between serum phosphorous and post-thyroidectomy serum calcium levels.


Keywords


Total thyroidectomy, Serum phosphorus, Hypocalcaemia

Full Text:

PDF

References


Fischer JE. Biopsy, Lobectomy, Total Thyroidectomy and Lymph Node Dissection for Thyroid Cancer: Fischer’s Mastery Of Surgery: 7th edition. Wolters Kluwer. 2019;39:516-29.

Bailey HH, Love RJM. The thyroid gland. Bailey & Love's Short Practice of Surgery. 27th edition; CRC. 2018;50:800-22.

Bentrem DJ, Rademaker A, Angelos P. Evaluation of serum calcium levels in predicting hypoparathyroidism after total/ near-total thyroidectomy or parathyroidectomy. Am Surg. 2001;67:249-51.

Townsend CM, Beauchamp RD, Evers BM. Thyroid. Sabiston Textbook of Surgery. First South Asia edition. Elsevier. 36:881-921.

Brunicardi FC, Andersen DK, Billiar TR. Thyroid , Parathyroid and Adrenal. Schwartz’s Principles of Surgery. 11th edition. MCGraw Hill Canada publisher. 38:1625-81.

Nair CG, Babu MJC, Menon R. Hypocalcaemia following total thyroidectomy: An analysis of 806 patients. Indian J Endocrinol Metab. 2013;17(2):298-303.

Ade SA, Salles JM, Soares JM. Evolution of blood magnesium and phosphorus ion levels following thyroidectomy and correlation with total calcium values. Sao Paulo Med J. 2010;128:268-71.

Deepadarshan H, Hiremath SD. Lifestyle factors and lifestyle diseases among rural population of Bengaluru rural district. International Journal Community Med Public Health. 2017;4:1558-61.

Deokar. Prevalence of thyroid disorders in a tertiary care center. Int J Cur Res Rev. 2016;8(9):26-30.

Harris WV, De Beur JS. Postoperative hypoparathyroidism: medical and surgical therapeutic options. Thyroid. 2009;9:967-73.

Karamanakos SN, Markou KB, Panagopoulos K, Karavias D. Complications and risk factors related to the extent of surgery in thyroidectomy. Results from 2,043 procedures. Hormones. 2010;9:318-25.

Gac E P, Cabané T P, Amat V J. Incidence of hypocalcemia after total thyroidectomy. Rev Med Chil. 2007;135(1):26-30.

Khafif A, Pivoarov A, Medina JE. Parathyroid hormone: a sensitive predictor of hypocalcemia following total thyroidectomy. Otolaryngol Head Neck Surg. 2006;134(6):907-10.

Rio PD, Rossini M, Montana CM. Postoperative hypocalcemia: analysis of factors influencing early hypocalcemia development following thyroid surgery. BMC Surg. 2019;18(1):25.

Sam AH, Dhillo WS, Donaldson M. Serum phosphate predicts temporary hypocalcaemia following thyroidectomy. Clin Endocrinol (Oxf). 2011;74(3):388-93.

Edafe O, Prasad P, Harrison BJ. Incidence and predictors of post-thyroidectomy hypocalcaemia in a tertiary endocrine surgical unit. Ann R Coll Surg Engl. 2014;96(3):219-23.