Comparison of recovery profile between sevoflurane and isoflurane as volatile agents in neurosurgery in Indian population


  • Satyen Kumar Singh Department of Anesthesia, BHDC, Lucknow, Uttar Pradesh, India
  • Munish Kumar Department of Anesthesia, CHCC, Lucknow, Uttar Pradesh, India
  • Ajit Bhardwaj Department of Anesthesia, CHCC, Lucknow, Uttar Pradesh, India
  • Vikas Chawla Department of Anesthesia, CHCC, Lucknow, Uttar Pradesh, India
  • Ritu Grewal Department of Anesthesia, CHCC, Lucknow, Uttar Pradesh, India
  • Shivinder Singh Department of Anesthesia, CHCC, Lucknow, Uttar Pradesh, India



Halogenated anesthetics, Emergence, Blood gas solubility coefficient


Background: In most instances rapid emergence from general anesthesia after intracranial neurosurgery is desirable. The most compelling reason for this is the need for the patient to cooperate with a postoperative neurological examination intended to screen for such potential intracranial disaster as hematoma formation, herniation, and cerebrovascular accidents. Anesthetic techniques were adopted to achieve rapid emergence. In this respect, inhaled anesthetic agents have an important role in influencing the recovery time after anesthesia and surgery. The aim of this study is to compare isoflurane and sevoflurane as regard to speed of recovery from anesthesia and recovery of post-operative cognitive function in Indian population

Methods:  The study was carried out as randomized control, blinded study of patients undergoing neurosurgery in   tertiary care hospital. Sample sizes of 60 patients were studied. They were divided into two groups. 

Results: Sevoflurane shows faster emergence, extubation, motor control (in form of hand squeeze) and orientation time as compared to isoflurane. Though clinically the time difference for the various variables studied was 0.8 to 2.7 min only, statistically the results were significant and supported the basis for this difference as the difference in blood gas solubility coefficient between sevoflurane and isoflurane

Conclusions: Sevoflurane is recommended for use for faster extubation, emergence and post-operative neurological examination. The observation shows good brain relaxation with the use of both volatile anesthetic agents



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