DOI: http://dx.doi.org/10.18203/2349-2902.isj20213159

Testicular non-Hodgkin’s lymphoma – a rare tumor

Debarghya Chatterjee, Rakesh Vakil, Richa Jindal

Abstract


Primary lymphoma of the testis is an exceedingly rare disease. We present a case of a 65 years old gentleman who presented with a brief history of testicular pain. Imaging studies and serum tumour markers indicated a testicular lesion of suspicious aetiology. High inguinal orchidectomy was performed. Histopathology and immunohistochemistry revealed diffuse large B-cell lymphoma. Positron emission tomography (PET) scan revealed a metabolically active retroperitoneal lymph node in aortocaval location. Subsequently he underwent chemotherapy with Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) regimen plus intravenous Methotrexate, following which PET scan showed disappearance of the previously detected metabolically active lesion.


Keywords


Non-Hodgkin’s lymphoma, Testis

Full Text:

PDF

References


Chen B, Cao DH, Lai L, Guo JB, Chen ZY, Huang Y, et al. Adult primary testicular lymphoma: clinical features and survival in a series of patients treated at a high-volume institution in China. BMC Cancer. 2020;20(1):1.

Lantz AG, Power N, Hutton B, Gupta R. Malignant lymphoma of the testis: a study of 12 cases. Canad Urol Assoc J. 2009;3(5):393.

Xu H, Yao F. Primary testicular lymphoma: A SEER analysis of 1,169 cases. Oncol Lett. 2019;17(3):3113-24.

Avilés A, Neri N, Huerta-Guzmán J, Pérez F, Fernández R. Testicular lymphoma: organ-specific treatment did not improve outcome. Oncology. 2004;67(3-4):211-4.

Shenkier TN, Voss N, Fairey R, Gascoyne RD, Hoskins P, Klasa R, et al. Brief chemotherapy and involved-region irradiation for limited-stage diffuse large-cell lymphoma: an 18-year experience from the British Columbia Cancer Agency. J Clin Oncol. 2002;20(1):197-204.

Connors JM. Problems in lymphoma management: special sites of presentation. Oncology (Williston Park, NY). 1998;12(2):185.

Peñalver FJ, Sancho JM, de la Fuente A, Olave MT, Martín A, Panizo C, et al. Guidelines for diagnosis, prevention and management of central nervous system involvement in diffuse large B-cell lymphoma patients by the Spanish Lymphoma Group (GELTAMO). Haematologica. 2017;102(2):235-45.

Vitolo U, Chiappella A, Ferreri AJ, Martelli M, Baldi I, Balzarotti M, et al. First-line treatment for primary testicular diffuse large B-cell lymphoma with rituximab-CHOP, CNS prophylaxis, and contralateral testis irradiation: final results of an international phase II trial. J Clin Oncol. 2011;29(20):2766-72.