Synchronous breast carcinoma (with Paget’s disease) and renal cell carcinoma with tubercular axillary lymphadenitis: a rare presentation

Sonika Ranganath, Navin Rajendra Kasliwal, Aruna Karad Shah, Rohan Amit Maydeo


Synchronous malignancy are defined as two primary malignancy of two different organs occurring concurrently or within 6 months duration. Reports of synchronous breast carcinoma with RCC (renal cell carcinoma) are very limited. We presented here the first case of non-metastatic synchronous RCC with breast carcinoma and Paget’s disease associated with tubercular axillary lymphadenitis in a 62 year old female for which she underwent right MRM and right partial nephrectomy. She received chemotherapy and anti-tubercular therapy post-surgery and currently on oral hormonal therapy. Follow up scans showed stable disease. There have been cases of breast cancer with TB lymphadenitis as well as of double synchronous malignancies involving breast carcinoma and RCC. Most of the multiple malignancies reported in literature are metastatic tumours or metachronous breast malignancy with RCC. A case of synchronous primary ca breast with pages disease coexisting with primary RCC along with tubercular lymphadenopathy is yet to be reported in literature. This might just be the first one.


Synchronous malignancy, Dual malignancy, Synchronous breast carcinoma, RCC, Synchronous malignancy with TB, TB lymphaedenitis with breast carcinoma

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Segen's Medical Dictionary. Fact sheet: Synchronous Cancer. Available at: Accessed on 25 April 2021.

WHO. Fact sheet: Breast cancer. Available at: Accessed on 25 April 2021.

American Cancer Society. Fact sheet: Kidney Cancer. Available at: Accessed on 25 April 2021.

Akbulut S, Sogutcu N, Yagmur Y. Coexistence of breast cancer and tuberculosis in axillary lymph nodes: a case report and literature review. Breast Cancer Res Treat. 2011;130(3):1037-42.

Malvia S, Bagadi SA, Dubey US, Saxena S. Epidemiology of breast cancer in Indian women. Asia Pac J Clin Oncol. 2017;13(4):289-95.

Paget's Disease of the Breast: Symptoms, Diagnosis WebMD: Medically Reviewed by Gabriela Pichardo, Available at: Accessed on 20 March 2021.

Multiple primary malignant neoplasms: A 10-year experience at a single institution from Turkey by Durmus Etiz et all. Cancer journal, 2017, volume 13 issue 1. Available at:;year=2017;volume=13;issue=1;spage=16;epage=20;aulast=Etiz. Accessed on 20 March 2021.

Jiao F, Yao LJ, Zhou J, Hu H, Wang LW. Clinical features of multiple primary malignancies: a retrospective analysis of 72 Chinese patients. Asian Pac J Cancer Prev. 2014;15(1):331-4.

Kurlekar UA, Rayate AS. Synchronous primary malignancies in breast and kidney: a rare case report. Indian J Surg. 2015;77(1):6-9.

Arjunan R, Kumar D, Kumar KVV, Premlatha CS. Breast cancer with synchronous renal cell carcinoma: a rare presentation. J Clin Diagn Res. 2016;10(10):3-5.

Falagas ME, Kouranos VD, Athanassa Z, Kopterides P. Tuberculosis and malignancy. QJM Int J Med. 2010;103(7):461-87.

Kurul S, Akgun Z, Saglam EK, Basaran M, Yucel S, Tuzlali S. Successful treatment of triple primary tumor. Int J Surg Case Rep. 2013;4(11):1013-6.