A randomised study to evaluate wound outcome following delayed primary vs primary closure of skin in duodenal perforation peritonitis


  • Sajal Gupta Department of General Surgery, Vardhaman Mahavir Medical College and Safdarjung Hospital, New Delhi, India
  • Vimal Bhandari Department of Surgery, VMMC & Safdarjung Hospital, New Delhi, India
  • I. B. Dubey Department of Surgery, VMMC & Safdarjung Hospital, New Delhi, India




Delayed primary closure, Duodenal perforation, Wound outcome


Background: This study aimed to evaluate wound outcome following delayed primary versus primary closure of skin in duodenal perforation peritonitis.

Methods: The present study was a randomised interventional study that included 90 patients on accrual of duodenal perforation peritonitis which were divided into primary closure (PC) and delayed primary closure (DPC) groups comprising 45 patients each. The outcome measures were complications, surgical site infections, hospital stay and final wound status during the follow up of 30 days. Data collected was compared taking P-value <0.05 as significant.

Results: The patients were in the age group of 12–60 years, with men in majority in both groups. Mean SSI score in PC and DPC was comparable (2.67 SD 1.58 vs. 2 SD1.61, P=0.058). SSI was more in PC group than DPC group (11.11% vs. 2.22%, P<0.05). Wound/pus culture was positive in 62.22% in PC and 46.67% in DPC. Major complications like wound dehiscence was noticed mainly in PC group while minor Complications like Stitch abscess, granuloma, sinus was more in DPC group. Mean of duration of stay (days) was comparable between PC and DPC group (14.07 SD 7.64 vs. 13.96 SD 6.94, P=0.805). Final wound outcome after 30 days was healthy scar in majority of patients in PC and DPC group (57.78% vs. 66.67%) with no significant difference between them (p=0.434).

Conclusions: In conclusion, DPC showed comparable results with PC with similar SSI and wound healing without significant complications.


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Original Research Articles