A serendipitous case report of acute pancreatitis complicated by pseudocyst in a patient with COVID-19
Keywords:COVID-19, SARS-CoV-2, Acute pancreatitis, Pseudocyst
Acute pancreatitis is a common gastrointestinal disease, most frequently requiring acute hospitalization. During SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) pandemic, the etiologic agent of COVID-19, several studies described the involvement of other tissues besides the respiratory tract, such as the gastrointestinal tract. In pancreas, ACE-2 receptor is expressed in exocrine glands and islets, both being targets for the virus and subsequent pancreatic injury. There are few articles which report pancreatic injury in COVID-19 patients but most of them do not report acute pancreatitis. Diagnosing acute pancreatitis in the setting of COVID-19 pandemic is challenging and requires ruling out all other potential causes of pancreatitis. Herein we report a rare case of severe acute pancreatitis.
Singh H, Jain D. Acute pancreatitis complicating hepatitis A virus infection: A case report. Eastern J of Med Sci. 2017;1(2):71-2.
Garrido I, Liberal R, Macedo G. Review article: COVID-19 and liver disease-what we know on 1st May 2020. Aliment Pharmacol Ther. 2020;52(2):267-75.
Lankisch PG, Apte M, Banks PA. Acute pancreatitis. Lancet. 2015;386(9988):85-96.
Patel KP, Patel PA, Vunnam RR, Hewlett AT, Jain R, Jing R, et al. Gastrointestinal, hepatobiliary, and pancreatic manifestations of COVID-19. J Clin Virol. 2020;128:104386.
Goodchild G, Chouhan M, Johnson GJ. Practical guide to the management of acute pancreatitis. Frontline Gastroenterol. 2019;10(3):292-9.
Simons LCR, Imam Z, Chahal P. Viral-Attributed Acute Pancreatitis: A Systematic Review. Dig Dis Sci. 2020.
Bourgonje AR, Abdulle AE, Timens W, Hillebrands JL, Navis GJ, Gordijn SJ, et al. Angiotensin-converting enzyme 2 (ACE2), SARS-CoV-2 and the pathophysiology of coronavirus disease 2019 (COVID-19). J Pathol. 2020;251(3):228-48.
Jin X, Lian JS, Hu JH, Gao J, Zheng L, Zhang YM, et al. Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms. Gut. 2020;69(6):1002-9.
Pan L, Mu M, Yang P, Sun Y, Wang R, Yan J, et al. Clinical Characteristics of COVID-19 Patients With Digestive Symptoms in Hubei, China: A Descriptive, Cross-Sectional, Multicenter Study. Am J Gastroenterol. 2020;115(5):766-73.
Liu F, Long X, Zhang B, Zhang W, Chen X, Zhang Z. ACE2 Expression in Pancreas May Cause Pancreatic Damage After SARS-CoV-2 Infection. Clin Gastroenterol Hepatol. 2020;18(9):2128-30.
Schepis T, Larghi A, Papa A, Miele L, Panzuto F, Biase L, et al. SARS-CoV2 RNA detection in a pancreatic pseudocyst sample. Pancreatology. 2020;20(5):1011-12.
Gonzalo VA, Fernandez PTCU, Baena DJM. Acute pancreatitis in a patient with COVID-19 infection. Med Clin. 2020;155(4):183-4.
Lakshmanan S, Malik A. Acute Pancreatitis in Mild COVID-19 Infection. Cureus. 2020;12(8):9886.
Brikman S, Denysova V, Menzal H, Dori G. Acute pancreatitis in a 61-year-old man with COVID-19. CMAJ. 2020;192(30):858-9.
Meireles PA, Bessa F, Gaspar P, Parreira I, Silva VD, Mota C, et al. Acalculous Acute Pancreatitis in a COVID-19 Patient. Eur J Case Rep Intern Med. 2020;7(6):1710.
Yang JK, Lin SS, Ji XJ, Guo LM. Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes. Acta Diabetol. 2010;47(3):193-9.
Madaria E, Capurso G. COVID-19 and acute pancreatitis: examining the causality. Nat Rev Gastroenterol Hepatol. 2021;18(1):3-4.
Inamdar S, Benias PC, Liu Y, Sejpal DV, Satapathy SK, Trindade AJ, et al. Prevalence, Risk Factors, and Outcomes of Hospitalized Patients With Coronavirus Disease 2019 Presenting as Acute Pancreatitis. Gastroenterology. 2020;159(6):2226-8.
Miro O, Llorens P, Jimenez S, Pinera P, Burillo-Putze G, Martin A, et al. Frequency of five unusual presentations in patients with COVID-19: results of the UMC-19-S1. Epidemiol Infect. 2020;148:189.
AlHarmi RAR, Fateel T, Sayed AJ, AlAwadhi K. Acute pancreatitis in a patient with COVID-19. BMJ Case Rep. 2021;14(2):239656.