Effect of topical phenytoin with normal saline dressing in patients of diabetic foot ulcers


  • Manohar Srinivas Reddy Department of Surgery, Sri Devraj Urs Medical College and Research Institute, Kollar, India
  • Chandrashekar Reddy Jagadish Madinur Department of General Surgery, Navodaya Medical College, Raichur, India




Diabetic ulcers, Topical phenytoin, Normal saline dressing, Wound area


Background: The management of wound and wound dressing is an important aspect of chronic ulcer management. Choosing an appropriate dressing can be a complex process. Topical phenytoin helps in faster wound remodelling. The objective of the study was to assess the effect of topical phenytoin dressing with normal saline dressing in healing of diabetic foot ulcer in terms of mean decrease in size of the ulcer.

Methods: The present study was conducted on 60 patients with diabetic foot ulcer. The patients were divided into two different groups (group 1 topical phenytoin and group 2 normal saline dressing). Wound measurement was taken on day one and end of every week for four weeks. Mean reduction in ulcer area at the end of four weeks was calculated.

Results: There was no statistical difference in the baseline characteristics like age, sex and initial wound area of the ulcer between the two groups. The mean reduction in wound area was 1856.9±724.9 mm2 in patients treated with topical phenytoin dressings and 1066.8±565.3 mm2 in patients treated with normal saline dressings, which is statically significant (p<0.001).

Conclusions: The study concluded that the topical phenytoin dressing can be used for the healing of diabetic foot ulcer.



Boulton AJM. The diabetic foot. Med Clinic North Am. 1988;72(6):1513-30.

Most RS, Sinnock P, Epidemiology of lower extremity amputation in diabetic individuals. Diabet Care. 1983;2:87-91.

Mann CV, Russel RCG, Williams NS. Bailey and Love’s Short Practice of Surgery. 24th ed. New York: Hodder Arnold Publication; 1995.

Muthukumarswamy MG, Shivakumar G, Manoharan G. Topical phenytion in diabetic foot ulcer. Diabetic Care. 1991;14(10):909-11.

Pai MRSM, Shrivastava N, Kotain MS. Topical phenytoin in diabic ulcer: double blind control trail. Ind J Med. 2001;55(11):513-99.

Bhatia A, Surya P. Topical phenytoin in wound healing. Dermatology Online J. 2004;10(1):5.

Shaw J, Hughes CM, Lagan KM, Bell PM. The clinical effect of tropical phenytoin on wound healing: a systemic review. Br J Dermatol. 2007;157(5):997-04.

Pendse AK, Sharma A, Sodani A, Hada S. Topical phenytoin in wound healing. Int J Dermatol. 1993;32(3):214-9.

Kumar N, Mukul B. Phenytoin treatment of ulcer. Int J Dermatol. 1993;32(3):210-3.

Edmonds M, Foster A. The use of antibiotics in the diabetic foot. Am J Surg. 2004;187:25-8.

O'Meara SM, Cullum NA, Majid M, Sheldon TA. Systematic review of antimicrobial agents used for chronic wounds. Br J Surg. 2001;88(1):4-21.

Zayat SG. Preliminary experience with topical phenytoin in wound healing in war zone. Milit Med. 1989;154(4):178-80.

Lodha SC. Lohiya ML, Vyas MC, Bhandari S, Goyal RR, Harsh MK. Role of phenytoin in healing of large abscess cavities. Br J Surg. 1991;78(1):105-8.

Ashima B, Surya P. Topical phenytoin for wound healing. Dermatol Online J. 2009;10(1):5.






Original Research Articles