Published: 2021-04-28

Cervical lymphadenopathy: a clinicopathological study

Chetas H. Guruswamy, K. Ananth Prabhu, H. R. Basavaraj


Background: Aim of the study was to evaluate the clinical presentation and histopathological findings in patients presenting with cervical lymphadenopathy.

Methods: Patients presenting to the outpatient units and admitted in the wards of departments of general surgery and onco-surgery, Yenepoya medical college hospital, Mangalore from December 2017 to December 2019 were included in the study.

Results: From December 2017 to December 2019, 130 patients had presented with cervical lymphadenopathy to our hospital. Cervical lymphadenopathy was most common in the age group of 50-60 years and in males. The most common histopathological diagnosis was found to be secondaries in the neck. Multiple lymph node level involvement was more common.

Conclusions: To conclude, cervical lymphadenopathy is seen frequently. In this study conducted in a tertiary centre 130 cases were reported in a span of two years of the study period. Further analysis of age and gender distribution, clinical and histopathological analysis suggested that in majority, age group was found to be above 50 years, with male preponderance. Commonest cause was secondaries in the neck (28.5%) followed by tubercular lymphadenitis (24.6%).


Lymphadenopathy, Neck, Secondaries, Lymphoma, Tuberculosis

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Mohseni S, Shojaiefard A, Khorgami Z, Alinejad S, Ghorbani A, Ghafouri A. Peripheral lymphadenopathy: approach and diagnostic tools. Iranian j med sci. 2014;39(2):158.

Biswas G, Das A, Haldar D, Mukherjee A, Dutta S, Sinha R. Clinico-pathological correlates of cervical lymphadenopathy: a hospital-based study. Indian J Otolaryngol Head Neck Surg. 2013;65(1):42-7.

Ramadas AA, Jose R, Varma B, Chandy ML. Cervical lymphadenopathy: Unwinding the hidden truth. Dental res J. 2017;14(1):73.

Sreenidhi GM, Nandeeshkumar GN. Clinicopathological study of cervical tubercular lymphadenopathy at KIMS hospital Bangalore. J Evolution Med Dental Sci. 2013;2(44):8655-67.

Chamyal PC, Sabarigirish K. Clinico-pathological correlation study of cervical lymph node masses. Indian J Otolaryngol Head Neck Surg. 1997;49(4):402-5.

Bazemore A, Smucker DR. Lymphadenopathy and malignancy. Am family physician. 2002;66(11):2103.

Ferrer R. Lymphadenopathy: differential diagnosis and evaluation. Am family physician. 1998;58(6):1313.

Sakr M. Cervical: Lymphadenopathy. In Head and Neck and Endocrine Surgery. 2016;163-90).

Hamoir M, Desuter G, Grégoire V, Reychler H, Rombaux P, Lengelé B. A proposal for redefining the boundaries of level V in the neck: is dissection of the apex of level V necessary in mucosal squamous cell carcinoma of the head and neck?. Arch Otolaryngol Head Neck Surg. 2002;128(12):1381-3.

Robbins KT, Medina JE, Wolfe GT, Levine PA, Sessions RB, Pruet CW. Standardizing neck dissection terminology. Official report of the Academy’s Committee for Head and Neck Surgery and Oncology. Arch Otolaryngol Head Neck Surg. 1991;117:601-5.

Robbins KT, Clayman G, Levine PA, Medina J, Sessions R, Shaha A et al. Neck dissection classification update: revisions proposed by the American Head and Neck Society and the American Academy of Otolaryngology-Head and Neck Surgery. Arch Otolaryngol Head Neck Surg. 2002;128(7):751-8.

Som PM, Curtin HD, Mancuso AA. An imaging-based classification for the cervical nodes designed as an adjunct to recent clinically based nodal classifications. Arch Otolaryngol Head Neck Surg. 1999;125(4):388-96.

Leung AK, Robson WL. Childhood cervical lymphadenopathy. J Pediatric Health Care. 2004;18(1):3-7.

Motiwala MA, Dalmia D, Behara SK. Cervical lymphadenopathy: a clinicopathological study. Int J Otorhinolaryngol Head Neck Surg. 2017;3:210-5.

Balm AJ, Van Velthuysen ML, Hoebers FJ, Vogel WV, Van den Brekel MW. Diagnosis and treatment of a neck node swelling suspicious for a malignancy: an algorithmic approach. Int J surgical oncol. 2010;2010.

Silva P, Hulse P, Sykes AJ, Carrington B, Julyan PJ, Homer JJ et al. Should FDG-PET scanning be routinely used for patients with an unknown head and neck squamous primary? J laryngol otol. 2007;121(2):149.

Mohseni S, Shojaiefard A, Khorgami Z, Alinejad S, Ghorbani A, Ghafouri A. Peripheral lymphadenopathy: approach and diagnostic tools. Iranian J med sci. 2014;39(2):158

Veetil SK, Sharma B. Clinical spectrum and histopathological analysis of cervical lymphadenopathy: a rural hospital study. Int Surg J. 2020;7(8):2573-7.

Jha BC, Dass A, Nagarkar NM, Gupta R, Singhal S. Cervical tuberculous lymphadenopathy: changing clinical pattern and concepts in management. Postgraduate med J. 2001;77(905):185-7.

Baskota DK, Prasad R, Sinha BK, Amatya RC. Distribution of lymph nodes in the neck in cases of tuberculous cervical lymphadenitis. Acta oto-laryngologica. 2004;124(9):1095-8.