Risk factors for the onset of gallbladder cancer: a review
DOI:
https://doi.org/10.18203/2349-2902.isj20212301Keywords:
Gallbladder neoplasms, Morbidity, Risk factors, ReviewAbstract
Gallbladder cancer (GBC) is the most common malignancy of the biliary system in clinic, which has the characteristics of insidious onset and high degree of malignancy. Most patients have progressed to an advanced stage when they are diagnosed. Early identification of risk factors of the onset of gallbladder cancer and active intervention are the key to improve the rate of early diagnosis and prognosis of gallbladder cancer. At present, the risk factors related to the onset of gallbladder cancer include gallstone, gallbladder polyps, primary sclerosing cholangitis, etc. In this review, we discuss the relevant latest research on the risk factors of the onset of gallbladder cancer in order to provide clinical evidence for the prevention and early diagnosis of gallbladder cancer. The intervention, follow-up, and monitoring of risk factors should be strengthened, and the possibility of malignancy of the gallbladder should be accurately assessed in combination with factors such as age and sex. In the case of possible malignancy, prophylactic cholecystectomy should be actively performed.
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References
Hundal R, Shaffer EA. Gallbladder cancer: epidemiology and outcome. Clin Epidemiol. 2014;6:99-109.
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424.
Duffy A, Capanu M, Abou GK, Huitzil D, Jarnagin W, Fong Y, Angelica M, et al. Gallbladder cancer (GBC): 10-year experience at Memorial Sloan-Kettering Cancer Centre (MSKCC). J Surg Oncol. 2008;98(7):485-9.
Van DAL, Shiels MS, Jones GS, Pfeiffer RM, Petrick JL, Beebe JL, Koshiol J. Biliary tract cancer incidence and trends in the United States by demographic group, 1999-2013. Cancer. 2019;125(9):1489-98.
Muszynska C, Lundgren L, Lindell G, Andersson R, Nilsson J, Sandstrom P, Andersson B. Predictors of incidental gallbladder cancer in patients undergoing cholecystectomy for benign gallbladder disease: Results from a population-based gallstone surgery registry. Surgery. 2017;162(2):256-63.
Pitt SC, Jin LX, Hall BL, Strasberg SM, Pitt HA. Incidental gallbladder cancer at cholecystectomy: when should the surgeon be suspicious? Ann Surg. 2014;260(1):128-33.
Rahman R, Simoes EJ, Schmaltz C, Jackson CS, Ibdah JA. Trend analysis and survival of primary gallbladder cancer in the United States: a 1973-2009 population-based study. Cancer Med. 2017;6(4):874-80.
Wi Y, Woo H, Won YJ, Jang JY, Shin A. Trends in Gallbladder Cancer Incidence and Survival in Korea. Cancer Res Treat. 2018;50(4):1444-51.
Randi G, Franceschi S, La Vecchia C. Gallbladder cancer worldwide: geographical distribution and risk factors. Int J Cancer. 2006;118(7):1591-602.
Lammert F, Gurusamy K, Ko CW, Miquel JF, Mendez SN, Portincasa P, et al. Gallstones. Nat Rev Dis Primers. 2016;2:16024.
Hsing AW, Bai Y, Andreotti G, Rashid A, Deng J, Chen J, Goldstein AM, et al. Family history of gallstones and the risk of biliary tract cancer and gallstones: a population-based study in Shanghai, China. Int J Cancer. 2007;121(4):832-8.
Cariati A, Piromalli E, Cetta F. Gallbladder cancers: associated conditions, histological types, prognosis, and prevention. Eur J Gastroenterol Hepatol. 2014;26(5):562-9.
Jain K, Mohapatra T, Das P, Misra MC, Gupta SD, Ghosh M, et al. Sequential occurrence of preneoplastic lesions and accumulation of loss of heterozygosity in patients with gallbladder stones suggest causal association with gallbladder cancer. Ann Surg. 2014;260(6):1073-80.
Andrea C, Enzo A. Cholesterol Gallstones Larger Than 3 cm Appear to Be Associated With Gallbladder Cancer: Identification of a High Risk Group of Patients That Could Benefit From Preventive Cholecystectomy. Ann Surg. 2016;263(3):56.
Wiles R, Thoeni RF, Barbu ST, Vashist YK, Rafaelsen SR, Dewhurst C, et al. Management and follow-up of gallbladder polyps: Joint guidelines between the European Society of Gastrointestinal and Abdominal Radiology (ESGAR), European Association for Endoscopic Surgery and other Interventional Techniques (EAES), International Society of Digestive Surgery - European Federation (EFISDS) and European Society of Gastrointestinal Endoscopy (ESGE). Eur Radiol. 2017;27(9):3856-66.
Szpakowski JL, Tucker LY. Outcomes of Gallbladder Polyps and Their Association With Gallbladder Cancer in a 20-Year Cohort. JAMA Netw Open. 2020;3(5):205143.
Fujiwara K, Abe A, Masatsugu T, Hirano T, Sada M. Effect of gallbladder polyp size on the prediction and detection of gallbladder cancer. Surg Endosc. 2020.
Wu T, Sun Z, Jiang Y, Yu J, Chang C, Dong X, Yan S. Strategy for discriminating cholesterol and premalignancy in polypoid lesions of the gallbladder: a single-centre, retrospective cohort study. ANZ J Surg. 2019;89(4):388-92.
Babu BI, Dennison AR, Garcea G. Management and diagnosis of gallbladder polyps: a systematic review. Langenbecks Arch Surg. 2015;400(4):455-62.
Patel K, Dajani K, Vickramarajah S, Huguet E. Five year experience of gallbladder polyp surveillance and cost effective analysis against new European consensus guidelines. HPB. 2019;21(5):636-42.
Kim JH, Jeong IH, Han JH, Kim JH, Hwang JC, Yoo BM, et al. Clinical/pathological analysis of gallbladder adenomyomatosis; type and pathogenesis. Hepatogastroenterology. 2010;57(99):420-5.
Howe L, Kowdley GC, Cunningham SC. Gallbladder adenomyomatosis: not always benign. HPB. 2017;19(6):557.
Morikawa T, Okabayashi T, Shima Y, Sumiyoshi T, Kozuki A, Saisaka Y, et al. Adenomyomatosis Concomitant with Primary Gallbladder Carcinoma. Acta Med Okayama. 2017;71(2):113-8.
Fung BM, Lindor KD, Tabibian JH. Cancer risk in primary sclerosing cholangitis: Epidemiology, prevention, and surveillance strategies. World J Gastroenterol. 2019;25(6):659-71.
Razumilava N, Gores GJ, Lindor KD. Cancer surveillance in patients with primary sclerosing cholangitis. Hepatology. 2011;54(5):1842-52.
Said K, Glaumann H, Bergquist A. Gallbladder disease in patients with primary sclerosing cholangitis. J Hepatology. 2008;48(4):598-605.
Torabi SB, Edwards K, Shen B. Frequency, Risk Factors, and Outcome of Gallbladder Polyps in Patients With Primary Sclerosing Cholangitis: A Case-Control Study. Hepatol Commun. 2018;2(12):1440-5.
Rabiee A, Levy C. Medical management of primary sclerosing cholangitis. Clin Liver Dis. 2014;3(3):48-51.
Tabibian JH, Ali AH, Lindor KD. Primary Sclerosing Cholangitis, Part 2: Cancer Risk, Prevention, and Surveillance. Gastroenterol Hepatol. 2018;14(7):427-32.
Erp LW, Cunningham M, Narasimman M, Ale AH, Jhaveri K, Drenth JPH, et al. Risk of gallbladder cancer in patients with primary sclerosing cholangitis and radiographically detected gallbladder polyps. Liver Int. 2020;40(2):382-92.
Muraki T, Pehlivanoglu B, Memis B, Reid MD, Uehara T, Basturk O, et al. Pancreatobiliary Maljunction-Associated Gallbladder Cancer is as Common in the West, Shows Distinct Clinicopathologic Characteristics and Offers an Invaluable Model for Anatomy-Induced Reflux-Associated Physio-Chemical Carcinogenesis. Ann Surg. 2020.
Hyvarinen I, Hukkinen M, Kivisaari R, Parviainen H, Nordin A, Pakarinen MP. Increased prevalence of pancreaticobiliary maljunction in biliary malignancies. Scand J Surg. 2019;108(4):285-90.
Fujimoto T, Ohtsuka T, Nakashima Y, Gotoh Y, Date K, Mori Y, et al. Elevated bile amylase level without pancreaticobiliary maljunction is a risk factor for gallbladder carcinoma. J Hepatobiliary Pancreat Sci. 2017;24(2):103-8.
Kamisawa T, Kuruma S, Chiba K, Tabata T, Koizumi S, Kikuyama M. Biliary carcinogenesis in pancreaticobiliary maljunction. J Gastroenterol. 2017;52(2):158-63.
Schnelldorfer T. Porcelain gallbladder: a benign process or concern for malignancy?. J Gastrointest Surg. 2013;17(6):1161-8.
Chen GL, Akmal Y, Fronzo AL, Vuong B, Connor V. Porcelain Gallbladder: No Longer an Indication for Prophylactic Cholecystectomy. Am Surg. 2015;81(10):936-40.
Des JH, Duy L, Scheirey C, Schnelldorfer T. Porcelain Gallbladder: Is Observation a Safe Option in Select Populations?. J Am Coll Surg. 2018;226(6):1064-9.
Koshiol J, Wozniak A, Cook P, Adaniel C, Acevedo J, Azocar L, et al. Salmonella enterica serovar Typhi and gallbladder cancer: a case-control study and meta-analysis. Cancer Med. 2016;5(11):3325-310.
Di DEG, Cavallo I, Pontone M, Toma L, Ensoli F. Biofilm Producing Salmonella Typhi: Chronic Colonization and Development of Gallbladder Cancer. Int J Mol Sci. 2017;18(9):1887.
Hassan EH, Gerges SS, Atrebi KA, Bassyouni HT. The role of H. pylori infection in gall bladder cancer: clinicopathological study. Tumour Biol. 2015;36(9):7093-8.
Jackson SS, Adami HO, Andreotti G, Beane FLE, Gonzalez AB, Buring JE, et al. Associations between reproductive factors and biliary tract cancers in women from the Biliary Tract Cancers Pooling Project. J Hepatol. 2020;73(4):863-72.
Andreotti G, Hou L, Gao YT, Brinton LA, Rashid A, Chen J, et al. Reproductive factors and risks of biliary tract cancers and stones: a population-based study in Shanghai, China. Br J Cancer. 2010;102(7):1185-9.
Makiuchi T, Sobue T, Kitamura T, Sawada N, Iwasaki M, Sasazuki S, et al. Reproductive factors and gallbladder/bile duct cancer: a population-based cohort study in Japan. Eur J Cancer Prev. 2017;26(4):292-300.
Saranga Bharathi R, Singh R, Gupta R, Verma GR, Kalra N, Kiran K, et al. Female sex hormone receptors in gallbladder cancer. J Gastrointest Cancer. 2015;46(2):143-8.
Arnold M, Pandeya N, Byrnes G, Renehan PAG, Stevens GA, Ezzati PM, et al. Global burden of cancer attributable to high body-mass index in 2012: a population-based study. Lancet Oncol. 2015;16(1):36-46.
Bhaskaran K, Douglas I, Forbes H, Santos SI, Leon DA, Smeeth L. Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5·24 million UK adults. Lancet. 2014;384(9945):755-65.
Tan W, Gao M, Liu N, Zhang G, Xu T, Cui W. Body Mass Index and Risk of Gallbladder Cancer: Systematic Review and Meta-Analysis of Observational Studies. Nutrients. 2015;7(10):8321-34.
Li L, Gan Y, Li W, Wu C, Lu Z. Overweight, obesity and the risk of gallbladder and extrahepatic bile duct cancers: A meta-analysis of observational studies. Obesity. 2016;24(8):1786-802.
Campbell PT, Newton CC, Kitahara CM, Patel AV, Hartge P, Koshiol J, et al. Body Size Indicators and Risk of Gallbladder Cancer: Pooled Analysis of Individual-Level Data from 19 Prospective Cohort Studies. Cancer Epidemiol Biomarkers Prev. 2017;26(4):597-606.
Schmidt MA, Marcano BL, Roberts LR. Gallbladder cancer: epidemiology and genetic risk associations. Chin Clin Oncol. 2019;8(4):31.
Henley SJ, Weir HK, Jim MA, Watson M, Richardson LC. Gallbladder Cancer Incidence and Mortality, United States 1999-2011. Cancer Epidemiol Biomarkers Prev. 2015;24(9):1319-26.
Lorenzo BJ, Boekstegers F, Gonzalez SR, Marcelain K, Baez BP, Barahona PC, et al. Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile. PLoS Genet. 2017;13(5):1006756.
Jackson SS, Van DWV, Pfeiffer RM, Cook P, Hildesheim A, Pinto LA, et al. Inflammatory profiles in Chilean Mapuche and non-Mapuche women with gallstones at risk of developing gallbladder cancer. Sci Rep. 2021;11(1):3686.
Aldouri AQ, Malik HZ, Waytt J, Khan S, Ranganathan K, Kummaraganti S, et al. The risk of gallbladder cancer from polyps in a large multiethnic series. Eur J Surg Oncol. 2009;35(1):48-51.
Yagyu K, Kikuchi S, Obata Y, Lin Y, Ishibashi T, Kurosawa M, et al. JACC Study Group. Cigarette smoking, alcohol drinking and the risk of gallbladder cancer death: a prospective cohort study in Japan. Int J Cancer. 2008;122(4):924-9.
Lugo A, Peveri G, Gallus S. Should we consider gallbladder cancer a new smoking-related cancer? A comprehensive meta-analysis focused on dose-response relationships. Int J Cancer. 2020;146(12):3304-11.
Makiuchi T, Sobue T, Kitamura T, Ishihara J, Sawada N, Iwasaki M, et al. The relationship between vegetable/fruit consumption and gallbladder/bile duct cancer: A population-based cohort study in Japan. Int J Cancer. 2017;140(5):1009-19.
Larsson SC, Hakansson N, Wolk A. Healthy dietary patterns and incidence of biliary tract and gallbladder cancer in a prospective study of women and men. Eur J Cancer. 2017;70:42-7.
Nogueira L, Foerster C, Groopman J, Egner P, Koshiol J, Ferreccio C. Association of aflatoxin with gallbladder cancer in Chile. JAMA. 2015;313(20):2075-7.
Koshiol J, Gao YT, Dean M, Egner P, Nepal C, Jones K, et al. Association of Aflatoxin and Gallbladder Cancer. Gastroenterology. 2017;153(2):488-94.
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