DOI: http://dx.doi.org/10.18203/2349-2902.isj20210992

Rare case of gastric extranodal marginal zone lymphoma

Devisha Raina

Abstract


True histiocytic lymphoma is considered a rare entity, and its diagnosis requires the concordance of morphological, immunophenotypic, and molecular findings. Gastric extra nodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) is a B-cell non-Hodgkin lymphoma that arises in the stomach and has a perifollicular/marginal zone growth pattern. The lymphoma is derived from marginal zone B-cells and recapitulates the architecture and organization of native MALT exemplified by the Peyers’ patches in the terminal ileum. Marginal zone lymphoma of MALT (MALT lymphoma) is the most common indolent subtype and represents 7% of all non-Hodgkin lymphomas.


Keywords


True histiocytic lymphoma, MALT lymphoma, Stomach extra nodal marginal zone B cell lymphoma, Mucosa associated lymphoid tissue, Polymerase chain reaction

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References


Isaacson PG. The MALT lymphoma concept updated. Ann Oncol. 1995;6:319-20.

Swerdlow SH, Campo E, Seto M. Mantle cell lymphoma. In: WHO classification of Tumors of Hematopoietic and Lymphoid Tissues. Lyon: IARC. 2008:229-32.

Zucca E, Conconi A, Pedrinis E, Cortelazzo S, Motta T, Gospodarowicz MK, et al. Non-gastric marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. Blood. 2003;101(7):2489-95.

Isaacson PG, Du M-G. MALT lymphoma: from morphology to molecules. Nat Rev Cancer. 2004; 4(8):644-53.

Fischbach W, Goebeler-Kolve ME, Dragosics B, Greiner A, Stolte M. Long term outcome of patients with gastric marginal zone B cell lymphoma of mucosa associated lymphoid tissue (MALT) following exclusive Helicobacter pylori eradication therapy: experience from a large perspective series. Gut. 2004;53(1):34-7.

El-Zimaity HMT, Wotherspoon A, De Jong D, Houston MALT lymphoma Workshop. Interobserver variation in the histopathological assessment of malt/malt lymphoma: towards a consensus. Blood Cells Mol Dis. 2005;34(1):6-16.

Hall PA, Jass JR, Levison DA, Morson BC, Shepherd NA, Sobin LH, et al. Classifying primary gut lymphomas. Lancet. 1988;2(8617):958.

Hamoudi RA, Appert A, Ye H, Ruskone-Fourmestraux A, Streubel B, Chott A, Raderer M et al. Differential expression of NF-kappaB target genes in MALT lymphoma with and without chromosome translocation: insights into molecular mechanism. Leukemia. 2010;24(8):1487-97.

Zullo A, Hassan C, Cristofari F, Andriani A, De Francesco V, Ierardi E et al. Effects of Helicobacter pylori eradication on early-stage gastric mucosa-associated lymphoid tissue lymphoma. Clin Gastroenterol Hepatol. 2010;8(2):105-10.

Musshoff K. Clinical staging classification of non-Hodgkin's lymphomas. Strahlentherapie. 1977;153(4):218-21.

Rohatiner A, D'Amore F, Coiffier B. Report on a workshop convened to discuss the pathological and staging classifications of gastrointestinal tract lymphoma. Ann Oncol. 1994;5(5):397-400.