Intraperitoneal liposarcoma: a rare presentation


  • Gokul Rajendran Department of General Surgery, Rajarajeshwari Medical College and Hospital, Bengaluru, Karnataka, India
  • Saichaithanya Kapuluru Department of General Surgery, Rajarajeshwari Medical College and Hospital, Bengaluru, Karnataka, India
  • Durganna Thimmappa Department of General Surgery, Rajarajeshwari Medical College and Hospital, Bengaluru, Karnataka, India



Liposarcoma, Intraperitoneal, Rare, Stomach


Liposarcoma are frequently seen in the retroperitoneum. It is of four types pathologically: Well-differentiated, dedifferentiated, myxoid and pleomorphic. Well-differentiated is the most common type. Dedifferentiated has the worst prognosis. Reports of Liposarcoma arising from the intraperitoneal sites such as stomach, omentum, mesentery and sigmoid mesocolon are rare. A 47 year old gentleman presented with pain in abdomen and abdominal distention, had a provisional diagnosis of GIST, intra-peritoneal liposarcoma. Imaging revealed a well-defined encapsulated abdominal mass indicative of liposarcoma with fibrous differentiation/fibro-lipoma. On surgery a well encapsulated mass was excised completely arising from the greater curvature of stomach. The mass on histopathological examination indicated features suggestive of liposarcoma (well-differentiated) with IHC markers positive for S100, CDK4 and MDM2. A diagnosis of intraperitoneal liposarcoma form greater curvature of stomach was made. This was an exceedingly rare presentation of liposarcoma arising from the greater curvature of stomach with differential diagnosis of GIST which was ruled out with histopathological features and negative CD117 and CD34. Thus to conclude liposarcoma being quite common retroperitoneal tumor, has an exceedingly rare occurrence from intraperitoneal sites and should be taken as an exceedingly rare differential diagnosis for mass per abdomen.


Townsend CM, Beauchamp RD, Evers BM, Mattox K. Sabiston textbook of surgery: the biological basis of modern surgical practice. 1st ed. Philadelphia, PA: Elsevier Saunders; 2016.

Cai M, Siew CCH, Tay TKY, Tan GHC. Dedifferentiated liposarcoma with a rare presentation of disseminated intraperitoneal sarcomatosis: a case report. Int J Surg Case Rep. 2019;60:331-5.

Winn B, Gao J, Akbari H, Bhattacharya B. Dedifferentiated liposarcoma arising from the sigmoid mesocolon: a case report. World J Gastroenterol. 2007;13(30):4147-8.

Tos APD. Liposarcomas: diagnostic pitfalls and new insights. Histopathol. 2014;64(1):38-52.

Thway K. Well-differentiated liposarcoma and dedifferentiated liposarcoma: an updated review. Semin Diagno Pathol. 2019;36(2):112-21.

Grifasi C, Calogero A, Carlomagno N, Campione S, D’Armiento FP, Renda A. Intraperitoneal dedifferentiated liposarcoma showing MDM2 amplification: case report. World Journal Surg Oncol. 2013;11(1):1-5.

Karaman A, Kabalar ME, Ozcan O, Koca T, Binici DN. Intraperitoneal dedifferentiated liposarcoma: a case report. World J Gastroenterol. 2008;14(38):5927-9.

D'Annibale M, Cosimelli M, Covello R, Stasi E. Liposarcoma of the colon presenting as an endoluminal mass. World J Surg Oncol. 2009;7(1):78.

Garg PK, Jain BK, Dahiya D, Bhatt S, Arora VK. Mesenteric liposarcoma: report of two cases with review of literature. J Gastrointest Canc. 2014;45(1):170-4.

Okajima Y, Nishikawa M, Ohi M, Fukumoto Y, Kuroda K, Shimomukai H. Primary liposarcoma of the omentum. Postgrad Med J. 1993;69:157-8.

Kang W, Xue L, Wang G, Ma F, Feng X, Guo L, et al. Liposarcoma of the stomach: report of two cases and review of the literature. World J Gastroenterol. 2018;24(25):2776-84.

Crago AM, Dickson MA. Liposarcoma: multimodality management and future targeted therapies. Surg Oncol Clin. 2016;25(4):761-73.






Case Reports