Extraappendiceal goblet cell carcinoid of the transverse colon

Authors

  • Madison Bowles Department of General Surgery, Gold Coast University Hospital, Queensland, Australia

DOI:

https://doi.org/10.18203/2349-2902.isj20210391

Keywords:

Goblet cell carcinoid, Goblet cell adenocarcinoma, Extraappendiceal, Mucinous carcinoid, Transverse colon

Abstract

Goblet cell carcinoids (GCC) are a rare subgroup of neuroendocrine tumours which exhibit mixed endocrine and exocrine features and are almost exclusively localised to the appendix. A few cases of extraappendiceal GCC have been reported in the literature however these are exceedingly rare. They are biologically aggressive tumours that are believed to arise from pluripotent intestinal epithelial crypt base stem cells. Given their rarity, no guidelines currently exist for the management of extraappendiceal GCC, however treatment for GCC’s is generally based on their tumour stage in line with staging for typical adenocarcinomas. This case gives an account of a colonic goblet cell carcinoid within the transverse colon encountered in a 66-year-old male. A literature search did not identify any previous documented cases of a GCC at this location.  

References

Karaman H, Şenel F, Güreli M, Ekinci T, Topuz Ö. Goblet cell carcinoid of the appendix and mixed adenoneuroendocrine carcinoma: Report of three cases. World J Gastrointest Oncol. 2017;9(7):308-13.

2. National Organisation of Rare Disorders. Goblet cell carcinoid. Available at https://rarediseases.org/rare-diseases/goblet-cell-carcinoid/. Accessed on 02 November 2020.

Gui X, Qin L, Gao Z.H, Falck V, Harpaz N.Goblet cell carcinoids at extraappendiceal locations of gastrointestinal tract: an underrecognized diagnostic pitfall. J Surg Oncol. 2011;103:790-5

Holt N, Grønbæk H. Goblet cell carcinoids of the appendix. Scientific World J. 2013;2013:543696.

Koganti S, Gilchrist B, Bell T. Perforated Goblet Cell Carcinoid Tumours of the Appendix: Navigating the Management Conundrum. Int Surg. 2017;102:131–6.

Melnitchouk N, Meyerhardt J. Epithelial tumours of the appendix. Up To Date. Retrieved November 1, 2020, from https://www.uptodate.com/contents/epithelial-tumors-of-the-appendix?source=autocomplete&index=0~1&search=goblet%20cell%20adenocarci#H2321691100. Accessed on 02 November 2020.

Al-Zawi A, Khan K, Shah A, Asaad A, Salter V, Barron M, Eldruki S. Colonic Goblet Cell Carcinoid: Rarity of a Rarity! A Case Report and Review of Literature. Chirurgia (Bucharest, Romania: 1990;115(1):102.

Clift A, Kornasiewicz O, Drymousis P, Faiz O, Wasan H, Kinross J, et al. Goblet cell carcinomas of the appendix: rare but aggressive neoplasms with challenging management. Endocr Conn. 2018;7(2):268-77.

Shenoy S. Goblet cell carcinoids of the appendix: Tumor biology, mutations and management strategies. World J Gastrointest Surg. 2016;8(10):660-9.

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Published

2021-01-29

Issue

Section

Case Reports