Published: 2020-11-27

Pancreatic metastasis of mesenchymal chondrosarcoma

Cristina P. Camacho, Emília C. Fraga, Ana Almeida, Maria J. Amaral, Mario Sergio


Mesenchymal chondrosarcoma is an aggressive tumor with chondrogenic differentiation that typically develops in skeletal sites, such as craniofacial bones, ribs, ilium, femur, and the vertebrae. It counts less than 3% of primary chondrosarcomas, and about a third of these tumors develop extraskeletal sites such as the meninges, and soft tissue. We present a case of a 53-year-old female, that was diagnosed with mesenchymal chondrosarcoma in the left thigh and submitted to surgical excision. The patient's case was evaluated by a multidisciplinary team, and it was decided to maintain vigilance. In the 5 years, follow-up presented several pulmonary metastases that were submitted to pulmonary resections. Two years later, during imaging control, an abdominal computed tomography (CT) scan was performed and revealed a pancreatic mass of 3 centimeters, located in the pancreatic tail. The patient was submitted to an explorative laparoscopy and a distal pancreatectomy was performed. The biopsy gave the definitive result of the metastasis of mesenchymal chondrosarcoma.


Mesenchymal chondrosarcoma, Pancreas, Metastasis

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Cohen J, Solomon DS, Horvai A, Kakar S. Pancreatic involvement by mesenchymal chondrosarcoma harboring the HEY1-NCOA2 gene fusion. Human Pathol. 2016;58:340.

Paasch C, Santo G, Renate K, Strik W. Mesenchymal chondrosarcoma metastasize to the pancreas. BMJ. 2018;11(1):e2263469.

Fotiadis C, Charalambopoulos A, Chatzikokolis S, Zografos GC, Genetzakis M, Tringidou R. Extraskeletal myxoid chondrosarcoma metastatic to the pancreas: A case report. World J Gastroenterol. 2005;11(14):2203-05.

Tsukamoto S, Honoki K, Kido A, Fujii H, Enomoto Y, Ohbayashi C et al. Chemotherapy Improved Prognosis of Mesenchymal Chondrosarcoma with Rare Metastasis to the Pancreas. Case Reports in Oncological Medicine. 2014;2014:249757.

Fukuda A, de Castro Oliveira DL, Joaquim FA, Amstalden EMI, de Souza Queiroz L, Reis F. Vertebral body chondrosarcoma with metastasis to the scalp. BJR Case Rep. 2019;5:20180037.

Scheiderman BA, Kliethermes SA. Survival in mesenchymal chondrosarcoma varies based on age and tumor location: a survival analysis of the SEER database. Clin Orthop Relat Res. 2017;475:799-805.