DOI: http://dx.doi.org/10.18203/2349-2902.isj20205394

Solitary plasmacytoma: a rare entity

Siddhant Shrotriya, Vishal Rokade, Vaishnavi SRI Bandaru

Abstract


Plasmacytoma is a plasma cell disorder characterized by localized accumulation of neoplastic monoclonal plasma cells in bone, or in soft tissues with no skeletal component, without any evidence of systemic involvement as demonstrated by the lack of clonal plasma cells in the bone marrow and absence of features of end organ damage. Spine plasmacytoma is a rather common entity, but solitary occurrence is not. It is usually described as a single lytic lesion without signs of myeloma cells, which is later diagnosed on radiological investigations and confirmed on bone marrow examination and histopathology examination. Imaging diagnosis is extremely helpful in early diagnosis and planning appropriate treatment. We present a case of a 55 year old female with pain bilaterally in lower limbs. A routine MRI shows focal lesion in the right pedicle of L4 vertebrae with bulging discs.


Keywords


Plasmacytoma, MRI, Solitary bone plasmacytoma

Full Text:

PDF

References


Kongwad LI, Nair RP, Nayal B, Nagaraj A. Solitary plasmacytoma of the axial spine and dorsal spine: treatment dilemmas and review of literature. J Spine Neurosurg. 2017;6:2.

Thumallapally N, Meshref A, Mousa M, Terjanian T. solitary plasmacytoma: population based analysis of survival trends and effect of various treatment modalities in the USA. BMC cancer. 2017;17(1):13.

Caers J, Paiva B, Zamagni E, Leleu X, Bladé J, Kristinsson SY, et al. Diagnosis, treatment, and response assessment in solitary plasmacytoma: updated recommendations from a European expert panel. J Hematol Oncol. 2018;11(1):10.

Thumallapally N, Meshref A, Mousa M, Terjanian T. Solitary plasmacytoma:population based analysis of survival trends and effect of various treatment modalities in the USA. BMC cancer. 2017;17(1):13.

Salgado LR, Wang S, Adler A, Chang S, Ru M, Moshier E, et al. The Safety profile of concurrent therapy for multiple myeloma in the modern era. Adv Radiat Oncol. 2018; 27;4(1):112-7.

Dimopoulos MA, Moulopoulos LA, Maniatis A, Alexanian R. Solitary plasmacytoma of bone and asymptomatic multiple myeloma. Blood. 2000;96(6):2037-44.

Soutar R, Lucraft H, Jackson G, Reece A, Bird J, Low E, et al. Guidelines on the diagnosis and management of solitary plasmacytoma of bone and solitary extramedullary plasmacytoma. Br J Haematol. 2004;124(6):717-26.