Gastrointestinal duplication cysts: experience from a tertiary care center in North India and review of literature


  • Divya Aggarwal Department of Histopathology, PGIMER, Sector 12, Chandigarh, India
  • Kim Vaiphei Department of Histopathology, PGIMER, Sector 12, Chandigarh, India



Duplication cysts, Gastrointestinal cysts, Congenital cysts, Gastrointestinal duplication cysts


Background: Duplication cysts (DC) are uncommon congenital malformations which predominantly present in infants and young children. Owing to their variable clinical presentation, radiology and/or histopathology are often required to clinch the diagnosis. We present a case series of 66 patients, which is the largest series reported so far.

Methods: A search of prospectively maintained institutional database was carried out to identify patients who were diagnosed and operated for gastrointestinal DC between January 2013 and August 2018. For all cases, the demographic data, site of DC, details of clinical presentation, associated conditions and histopathology findings were recorded. The slides of all cases were retrieved and re-examined.

Results: The age range was 1 day to 47 years, with a slight male predominance (1.3:1). Ileum was the most common site followed by jejunum. Ectopic mucosae noted were gastric, pancreatic, biliary and respiratory. One case showed glial heterotopia. Perforation, gangrene and intussusception were among the co-existing pathologies noted.

Conclusions: Duplication cysts are rare congenital malformations. The variability in clinical presentation makes the diagnosis elusive. Timely diagnosis and appropriate management require a high index of suspicion and a holistic diagnostic approach with clinical, radiological and histopathological inputs. 

Author Biographies

Divya Aggarwal, Department of Histopathology, PGIMER, Sector 12, Chandigarh, India

Senior Resident, Department of Pathology

Kim Vaiphei, Department of Histopathology, PGIMER, Sector 12, Chandigarh, India


Department of Histopathology



Antaki F, Tringali A, Deprez P, Kwan V, Costamagna G, Le Moine O et al. A case series of symptomatic intraluminal duodenal duplication cysts: presentation, endoscopic therapy, and long-term outcome (with video). Gastrointest Endosc. 2008;67(1):163-8.

Berrocal T, Lamas M, Gutieérrez J, Torres I, Prieto C, del Hoyo ML. Congenital anomalies of the small intestine, colon, and rectum. Radiographics. 1999;19(5):1219-36.

Erginel B, Soysal FG, Ozbey H, Keskin E, Celik A, Karadag A et al. Enteric Duplication Cysts in Children: A Single-Institution Series with Forty Patients in Twenty-Six Years. World J Surg. 2017;41(2):620-24.

Balakrishnan K, Fonacier F, Sood S, Bamji N, Bostwick H, Stringel G. Foregut Duplication Cysts in Children. JSLS. 2017;21(2).

Macpherson RI. Gastrointestinal tract duplications: clinical, pathologic, etiologic, and radiologic considerations. Radiographics. 1993;13(5):1063-80.

Sharma S, Yadav AK, Mandal AK, Zaheer S, Yadav DK, Samie A. Enteric Duplication Cysts in Children: A Clinicopathological Dilemma. J Clin Diagn Res. 2015;9(8):EC08-11.

Pandey S, Srivastava A, Lal R, Yachha SK, Poddar U. Enteric duplication cysts in children: a target in algorithm for evaluation of lower gastrointestinal bleeding. Indian J Gastroenterol. 2014;33(3):285-8.

Liaqat N, Latif T, Khan FA, Iqbal A, Nayyar SI, Dar SH. Enteric duplication in children: A case series. Afr J Paediatr Surg. 2014;11(3):211-4.

Lopez-Fernandez S, Hernandez-Martin S, Ramírez M, Ortiz R, Martinez L, Tovar JA. Pyloroduodenal duplication cysts: treatment of 11 cases. Eur J Pediatr Surg. 2013;23(4):312-6.

Wiechowska-Kozłowska A, Wunsch E, Majewski M, Milkiewicz P. Esophageal duplication cysts: endosonographic findings in asymptomatic patients. World J Gastroenterol. 2012;18(11):1270-2.

Kieran SM, Robson CD, Nosé V, Rahbar R. Foregut duplication cysts in the head and neck: presentation, diagnosis, and management. Arch Otolaryngol Head Neck Surg. 2010;136(8):778-82.

Carachi R, Azmy A. Foregut duplications. Pediatr Surg Int. 2002;18(5-6):371-4.






Original Research Articles