An uncommon case of anterior mediastinal teratoma

Soorya C. Sekar, Navin Kasliwal, Anirudha Mandhane, Rohan A. Maydeo


Germ cell tumors (GCT) are commonly seen in both children and young adults. Teratomas are a form of GCT and histologically contain tissues derived from all three germ cell layers. These tumors can exhibit malignant behaviour, hence should be diagnosed and treated as early as possible. So, hereby present a case of 18-year-old female who presented with complaints of fever and cough with gradual onset from 20 days. A chest X-ray revealed growth in the left side of the chest. A high-resolution computed tomographic (HRCT) scan of the chest showed a large well-defined hypodense lesion in the left hilar region. Bronchoscopy showed extrinsic compression in the left main bronchus. The patient underwent anterolateral thoracotomy to remove a 9×9 cm mass lying in the mediastinum resting on pericardium. The histopathology specimen turned out to be a mature teratoma. This interesting case is described with its incidence, diagnosis and management protocols for the mediastinal teratoma.


Mediastinum, Teratoma, Germ cell tumour, Surgical excision

Full Text:



Le Fèvre C, Vigneron C, Schuster H, Walter A, Marcellin L, Massard G et al. Metastatic mediastinal mature teratoma with malignant transformation in a young man with an adenocarcinoma in a Klinefelter's syndrome: Case report and review of the literature. Cancer Radiother. 2018;22(3):255-63.

No TH, Seol SH, Seo GW, Kim D-II, Yang SY, Jeong CH et al. Benign Mature Teratoma in Anterior Mediastinum. J Clin Med Res. 2015;7(9):726-8.

Yalagachin GH. Anterior mediastinal teratoma- a case report with review of literature. Indian J Surg. 2013;75(1):182-4.

Kao CS, Bangs CD, Aldrete G, Cherry AM, Ulbright TM. A Clinicopathologic and Molecular Analysis of 34 Mediastinal Germ Cell Tumors Suggesting Different Modes of Teratoma Development. Am J Surg Pathol. 2018;42(12):1662-73.

Moeller KH, Rosado-de-Christenson ML, Templeton PA. Mediastinal mature teratoma: imaging features. AJR Am J Roentgenol. 1997;169(4):985-90.

Tian Z, Liu H, Li S, Chen Y, MA D, Han Z et al. Surgical treatment of benign mediastinal teratoma: summary of experience of 108 cases. J Cardiothorac Surg. 2020;15(1):36.

Fulcher AS, Proto AV, Jolles H. Cystic teratoma of the mediastinum: demonstration of fat/fluid level. AJR Am J Roentgenol. 1990;154(2):259-60.

Yendamuri S. Resection of a Giant Mediastinal Teratoma. Ann Thorac Surg. 2016;102(5):401-2.

Wu TT, Wang HC, Chang YC, Lee YC, Chang YL, Yang PC. Mature mediastinal teratoma: sonographic imaging patterns and pathologic correlation. J Ultrasound Med. 2002;21(7):759-65.

Suzuki H, Koh E, Hoshino I, Kishi H, Saitoh Y. Mediastinal teratoma complicated with acute mediastinitis. Gen Thorac Cardiovasc Surg. 2010;58(2):105-8.

Peterson CM, Buckley C, Holley S, Menias CO. Teratomas: a multimodality review. Curr Probl Diagn Radiol. 2012;41(6):210-9.

Yetkin U, Orgencalli A, Yuncu G, Gurbuz A. Large Mediastinal Teratoma Originating from the Aortic Adventitia. Tex Heart Inst J. 2004;31(3):309-12.

Zhou WW, Wang HW, Liu NN, Li JJ, Yuan W, Zhao R et al. Diagnosis of Malignancy of Adult Mediastinal Tumors by Conventional and Transesophageal Echocardiography. Chin Med J (Engl). 2015;128(8):1047-51.

Xiao-Dong L, Li Z, Xiu-Mei D, Ming-Bo T, Xiao-Cong W. Identification of a giant mediastinal teratoma by echocardiography: A case report. J Clin Ultrasound. 2019;47(6):380-3.