Postoperative clinical outcome of aortic valve surgery in elderly patients and the effect of advanced age on atrial fibrillation: a comparative retrospective study

Authors

  • Ferhat Borulu Department of Cardiovascular Surgery, Faculty of Medicine, Atatürk University, Erzurum, Turkey
  • Umit Arslan Department of Cardiovascular Surgery, Faculty of Medicine, Atatürk University, Erzurum, Turkey
  • Eyupserhat Çalik Department of Cardiovascular Surgery, Faculty of Medicine, Atatürk University, Erzurum, Turkey
  • Bilgehan Erkut Department of Cardiovascular Surgery, Faculty of Medicine, Atatürk University, Erzurum, Turkey

DOI:

https://doi.org/10.18203/2349-2902.isj20210361

Keywords:

Aortic stenosis, Aortic valve replacement, Advanced age, Atrial fibrillation, Mortality

Abstract

Background: This study was conducted to evaluate the clinical outcomes of aortic valve surgery in elderly patients and to determine the factors associated with atrial fibrillation.

Methods: Between 2011 and 2015, 54 patients who underwent isolated aortic valve replacement for aortic stenosis without preoperative arrhythmia were divided into two groups as 50-69 years old (group I; n=25) and 70 years and older (group II; n=29). Patient's medical record was retrospectively reviewed. Pre, peri and post operation data was compared. The deaths that occurred in the first 30 days were evaluated as mortality and complications as morbidity.

Results: Mortality rate was found 9.2% (5/54) (p=0.358) in the first 30 days and 8.1% (4/49) the first six months follow-up and no difference was found between the two groups (p=0.153).  The following parameters were observed in group 2 and were found statistically significant: average age (p<0.01), euroscore (p<0.01), duration of cardiopulmonary bypass (p<0.01), duration of mechanical ventilation (p<0.01), duration of stay in intensive care unit (p<0.01), duration of stay hospital (p=0.01), acute renal failure (p=0.03), the need for dialysis (p<0.01), atrial fibrillation (p=0.04), pneumonia (p=0.03) and pleural fluid (p=0.01). We found that new-onset atrial fibrillation associated with advanced age (p=0.02), hypertension (p=0.04), duration of cardiopulmonary bypass (p=0.03), duration of aortic cross-clamp (p<0.01), postoperative anaemia (p=0.04), high creatinine values (p<0.01) and cerebrovascular events (p<0.01).

Conclusions: Mortality rate was found 9.2% (5/54) (p=0.358) in the first 30 days and 8.1% (4/49) the first six months follow-up and no difference was found between the two groups (p=0.153).  The following parameters were observed in group 2 and were found statistically significant: average age (p<0.01), euroscore (p<0.01), duration of cardiopulmonary bypass (p<0.01), duration of mechanical ventilation (p<0.01), duration of stay in intensive care unit (p<0.01), duration of stay hospital (p=0.01), acute renal failure (p=0.03), the need for dialysis (p<0.01), atrial fibrillation (p=0.04), pneumonia (p=0.03) and pleural fluid (p=0.01). We found that new-onset atrial fibrillation associated with advanced age (p=0.02), hypertension (p=0.04), duration of cardiopulmonary bypass (p=0.03), duration of aortic cross-clamp (p<0.01), postoperative anaemia (p=0.04), high creatinine values (p<0.01) and cerebrovascular events (p<0.01).

References

Collart F, Feier H, Kerbaul F, Mouly-Bandini A, Riberi A, Mesana TG, et al. Valvular surgery in octogenarians: operative risks factors, evaluation of Euroscore and long term results. Eur J Cardio-thoracic Surg. 2005;27:276-80.

Kolh P, Kerzmann A, Honore C, Comte L, Limet R. Aortic valve surgery in octogenarians: predictive factors for operative and long-term results. Eur J Cardio-thoracic Surg. 2007;31:600-6.

Khan MF, Wendel CS, Movahed MR. Prevention of Post–Coronary Artery Bypass Grafting (CABG) Atrial Fibrillation: Efficacy of Prophylactic Beta-Blockers in the Modern Era A meta-analysis of latest randomized controlled trials. Ann Noninvasive Electrocardiol. 2013;18:58-68.

Banach M, Okon´ski P, Rysz J, Piechowiak M, Zasłonka J. Prevention and treatment of atrial fibrillation following cardiac surgery. Pol Merkur Lekarski. 2005;19:794-9.

Kohno H, Ueda H, Matsuura K, Tamura Y, Watanabe M, Matsumiya G. Long-term consequences of atrial fibrillation after aortic valve replacement. Asian Cardiovasc Thoracic Ann. 2017;1-13.

Dumani S, Likaj E, Kacani A, Dibra L, Petrela E, Beca V, Refatllari A. Incidence and Impact of Patient-Prosthesis Mismatch in Isolated Aortic Valve Surgery. Open Access Maced J Med. 2015;3(4):624-9.

Hernández-Vaquero D, Llosa JC, Díaz R, Khalpey Z, Morales C, López RAJ, Boye F. Impact of patient-prosthesis mismatch on 30-day outcomes in young and middle-aged patients undergoing aortic valve replacement. J Cardiothoracic Surg. 2012;7:46.

Roger V, Tajik A, Reeder G, Hayes S, Mullany C, Bailey K, et al. Effect of Doppler echocardiography on utilization of hemodynamic cardiac catheterization in the preoperative evaluation of aortic stenosis. Mayo Clin Proc. 1996:71;141-9.

Ekim H, Kutay V, Tuncer M, Mustafaoğlu F, Yakut C. Aort Darlığı Olan Hastalarda Aort Kapak Replasmanının Klinik Sonuçları. Van Tıp Dergisi. 2005;12:(4):228-31.

Sundt TM, Bailey MS, Moon MR, Mendeloff EN, Huddleston CB, Pasque MK, et al. Quality of Life After Aortic Valve Replacement at the Age of >80 Years. Circulation. 2000;102:70-4.

Chiappini B, Camurri N, Loforte A, Di Marco L, Di Bartolomeo R, Marinelli G. Outcome after aortic valve replacement in octogenarians. Ann Thorac Surg. 2004;78(1):85-9.

Langanay T, Flécher E, Fouquet O, Ruggieri VG, Tour BD, Félix C, et al. Aortic Valve Replacement in the Elderly: The Real Life. Ann Thorac Surg. 2012;93:70-8.

Banach M, Mariscalco G, Ugurlucan M, Mikhailidis PT, Barylski M, Rysz J. The significance of preoperative atrial fibrillation in patients undergoing cardiac surgery: preoperative atrial fibrillation—still underestimated opponent. Europace. 2008;10:1266-70.

Kuduvalli M, Grayson AD, Au J, Grotte G, Bridgewater B, Fabri BM, et al. A multi-centre additive and logistic risk model for in-hospital mortality following aortic valve replacement. Eur J Cardio-thoracic Surg. 2007;31:607-13.

Ngaage DL, Schaff HV, Barnes SA, Sundt TM III, Mullany CJ, Dearani JA, et al. Prognostic implications of preoperative atrial fibrillation in patients undergoing aortic valve replacement: is there an argument for concomitant arrhythmia surgery? Ann Thorac Surg. 2006;82:1392-9.

Banach M, Goch A, Misztal M, Rysz J, Jaszewski R, Goch JH. Predictors of paroxysmal atrial fibrillation in patients undergoing aortic valve replacement. J Thorac Cardiovasc Surg. 2007;134:1569-76.

Gilmanov D, Bevilacqua S, Murzi M, Cerillo AG, Gasbarri T, Kallushi E, Miceli A, Glauber M. Ann Thoracic Surg. 2013;96(3):837-43.

Filardo G, Hamilton C, Hamman B, Hebeler RF, Adams J, Grayburn P. New-Onset Postoperative Atrial Fibrillation and Long-Term Survival after Aortic Valve Replacement Surgery. Ann Thorac Surg. 2010;90:474-80.

Júnior FP, Filho GFT, Sant’anna JRM, Mondim Py M, Prates PR, Nesralla IA, et al. Advanced age and incidence of atrial fibrillation in the postoperative period of aortic valve replacement. Rev Bras Cir Cardiovasc. 2014;29(1):45-50.

Orlowska-Baranowska E, Baranowski R, Michalek P, Hoffman P, Rywik T, Rawczylska-Englert I. Prediction of paroxysmal atrial fibrillation after aortic valve replacement in patients with aortic stenosis: Identification of potential risk factors. J Heart Valve Dis. 2003;12:136-41.

Mistiaen W, Van Cauwelaert P, Muylaert P, Wuyts F, Harrisson F, Bortier H. Risk factors and survival after aortic valve replacement in octogenarians. J Heart Valve Dis. 2004;13:538-44.

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Published

2021-01-29

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Original Research Articles