A rare and interesting case report of Kikuchi-Fujimoto disease masquerading as tuberculosis
DOI:
https://doi.org/10.18203/2349-2902.isj20204170Keywords:
KFD, Necrotising lymphadenitis, Tuberculosis, Genetic, Cervical lymphadenopathyAbstract
Kikuchi-Fujimoto disease (KFD), or histiocytic necrotizing lymphadenitis, is a rare benign, self-limited condition, probably genetic, that mainly affects young women which often presents with localised lymphadenopathy and fever. Reporting the case of a 17-year-old girl, with a strong family history of tuberculosis, who presented to the surgery OPD with cervical lymphadenopathy and a history of anti-tubercular treatment for the same complaints two years back. An excision biopsy revealed necrotizing histiocytic lymphadenitis suggestive of KFD. Post-operative period was uneventful and patient had spontaneous resolution of her complaints upon follow up. It is quite difficult to make a pre-operative diagnosis of this disease, until the clinician has got a very high index of suspicion especially because of the more common differential diagnoses including extrapulmonary tuberculosis.
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Bosch X, Guilabert A, Miquel R, Campo E. Enigmatic Kikuchi-Fujimoto disease: a comprehensive review. Am J Clin Pathol. 2004;122(1):141-52.
Kikuchi M. Lymphadenitis showing focal reticulum cell hyperplasia with nuclear debris and phagocytosis. Nippon Ketsueki Gakkai Zasshi. 1972;35:378-80.
Fujimoto Y, Kozima Y, Hamaguchi K. Cervical necrotizing lymphadenitis: a new clinicopathological agent. Naika. 1972;20:920-27.
Turner RR, Martin J, Dorfman RF. Necrotizing lymphadenitis: a study of 30 cases. Am J Surg Pathol. 1983;7(2):115-23.
Dorfman RF. Histiocytic necrotizing lymphadenitis of Kikuchi and Fujimoto. Arch Pathol Lab Med. 1987;111(11):1026-9.
Pileri S, Kikuchi M, Helbron D, Lennert K. Histiocytic necrotizing lymphadenitis without granulocytic infiltration. Virchows Arch A Pathol Anat Histol. 1982;395(3):257-71.
Kikuchi-Fujimoto Disease: A Review-Perry and Choi , Arch Pathol Lab Med. 2018 Nov;148.
Bosch X, Guilabert A. Kikuchi-Fujimoto disease. Orphanet J rare dis. 2006;1:18.
Yen HR, Lin PY, Chuang WY, Chang ML, Chiu CH. Skin manifestations of Kikuchi-Fujimoto disease: case report and review. Eur J Pediatr. 2004;163(4-5): 210-13.
Mahajan T, Merriman RC, Stone MJ. Kikuchi-Fujimoto disease (histiocytic necrotizing lymphadenitis): report of a case with other autoimmune manifestations. Proc (Bayl Univ Med Cent). 2007;20(2):149-51.
Dumas G, Prendki V, Haroche J, Amoura Z, Cacoub P, Galicier L, et al. Kikuchi-Fujimoto disease: retrospective study of 91 cases and review of the literature. Medicine (Baltimore). 2014;93(24):372-82.
Stasiuk A, Teschke S, Williams GJ, Seftel MD. Kikuchi-Fujimoto disease: lymphadenopathy in siblings. CMAJ 2011;183:E58-60.
Amir ARA, Amr SS, Sheikh SS. Kikuchi-Fujimoto disease: report of familial occurrence in two humanleukocyte antigen in identical non-twin sisters. J Intern Med 2002;252:79-83.
Santana A, Lessa B, Galrao L, Lima I, Santiago M. Kikuchi-Fujimoto’s disease associated with systemic lupus erythematosus: case report and review of the literature. Clin Rheumatol. 2005;24(1):60-3.
Kwon SY, Kim TK, Kim YS, Lee KY, Lee NJ, Seol HY. CT findings in Kikuchi disease: analysis of 96 cases. AJNR Am J Neuroradiol. 2004;25(6):1099-102.
Shim EJ, Lee KM, Kim EJ, Kim HG, Jang JH. CT pattern analysis of necrotizing and nonnecrotizing lymph nodes in Kikuchi disease. PLoS One. 2017;12(7):0181169.
Kato H, Kanematsu M, Kato Z, Teramoto T, Kondo N, Hirose Y, et al. MR imaging findings of cervical lymphadenopathy in patients with Kikuchi disease. Eur J Radiol. 2011;80(3):576-81.
Tabata T, Takata K, Miyata-Takata T, Sato Y, Ishizawa S, Kunitomo T, et al. Characteristic Distribution Pattern of CD30-positive Cytotoxic T Cells Aids Diagnosis of Kikuchi-Fujimoto Disease. Appl Immunohistochem Mol Morphol. 2018;26(4):274-82.
Jang YJ, Park KH, Seok HJ. Management of Kikuchi's disease using glucocorticoid. J Laryngol Otol. 2000;114(9):709-11.
Hyun M, So IT, Kim HA, Jung H, Ryu SY. Recurrent Kikuchi's Disease Treated by Hydroxychloroquine. Infect Chemother. 2016;48(2):127-31.
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