Published: 2020-12-28

Cholelithiasis and its relation to body mass index and waist to hip ratio: an observational study

Darpan Bansal, Anuj Rattan, Gurpreet Singh Bhangu, Rupinder Singh


Background: There is increased incidence of gall stones and its variable presentations in India is a great need for a study which can provide information regarding risk factors associated with the formation of gallstones, prevalence of disease, clinical presentations and outcome of cholelithiasis. So present study done to find a relationship between body mass index (BMI) and waist to hip ratio (WHR) with cholelithiasis.

Methods: The observational study was conducted in tertiary care center of SGRD Amritsar comprised of 100 patients diagnosed with pain abdomen by cholelithiasis and control comprised of 100 patients with any other cause of pain abdomen. All patients were evaluated for BMI and waist to hip ratio. BMI was calculated according to the standard formula (Quetelet’s index). The WHR was measured according to WHO protocol. Statistical tests were applied as quantitative variables were compared using unpaired t-test/Mann-Whitney test (when the data sets were not normally distributed) between the two groups. Qualitative variables were compared using chi-Square test /Fisher’s exact test.

Results: A significant association of formation of gall bladder stones in female gender in comparison to their male counterpart and increased chances of formation of gall bladder stones in the patients having higher BMI and higher WHR.

Conclusion: Female gender and obesity is associated with increased risk of cholelithiasis.


Cholelithiasis, Body mass index, Waist to hip ratio

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Reshetnyak VI. Concept of the pathogenesis and treatment of cholelithiasis. World J Hepatol. 2012;4(2):18-23.

Channa NA, Khand F, Ghanghro AB, Soomro AM. Quantitative analysis of serum lipid profile in gallstone patients and controls. Pak J Anal Environ Chem. 2010;11(1):59-65.

Sharma MP, Duphare HV. Gallstone disease in north India: clinical and ultrasound profile in a referral hospital. J Clin Gastroentrol. 1990;12(5):547-9.

Erlinger S. Gallstones in obesity and weight loss. Eur J Gastroenterol Hepatol. 2000;12(12):1347-52.

Kratzer W, Mason RA, Kachele V. Prevalence of gallstones in sonographic surveys worldwide. J Clin Ultrasound. 1999;27(1):1-7.

Shabanzadeha DM, Sorensena LT, Jorgensenb T. Determinants for gallstone formation: a new data cohort study and a systematic review with meta-analysis. Scandi J of Gastroenterol. 2016;51(10):1239-48.

Guyton AC, Hall JE. Secretory functions of alimentary tract. In: Guyton AC, Hall JE, editors. Textbook of medical physiology. 11th edition. Philadelphia: Saunders; 2006;802-4.

Volzke H, Baumeister SE, Alte D, Hoffmann W, Schwahn C, John U et al. Independent risk factors for gallstone formation in a region with high cholelithiasis prevalence. Digestion. 2005;71(2):97-105.

Lai SW, Muo CH, Liao KF, Sung FC, Chen PC. Risk of acute pancreatitis in type 2 diabetes and risk reduction on antidiabetic drugs: a population-based cohort study in Taiwan. Am J Gastroenterol. 2011;106(9):1697-704.

Novacek G. Gender and gallstone disease. Wien Med Wochenschr. 2006;156(19-20):527-33.

Liu CM, Tung TH, Chou P, Chen VT, Hsu CT, Liu JH et al. Clinical correlation of gallstone disease in a Chinese population in Taiwan: experience at Cheng Hsin General Hospital. World J Gastroenterol. 2006;12(8):1281-6.

Stender S, Nordestgaard BG, Tybjaerg-Hansen A. Elevated body mass index as a causal risk factor for symptomatic gallstone disease: a Mendelian randomization study. Hepatol. 2013;58(6):2133-41.

Tsai CJ, Leitzmann MF, Willett WC, Giovannucci EL. Prospective study of abdominal adiposity and gallstone disease in US men. Am J Clin Nutr. 2004;80(1):38-44.

Cojocaru C, Pandele GI. Metabolic profile of patients with cholesterol gallstone disease. Rev Med Chir Soc Med Nat lasi. 2010;114(3):677-82.