Email this article Squamous cell carcinoma of gallbladder: a rare entity
Abstract
Adenocarcinoma is the most common variant of gallbladder carcinoma. Adenosquamous carcinoma and pure squamous cell carcinoma are rare variants accounting for only up to 3% of the tumors. Pure squamous cell carcinoma of the gallbladder is reported and its incidence is less than 1%. Usually they present at advanced stage and many of the times these are unresectable. Hence survival in patients with squamous cell carcinoma is less than adenocarcinoma, and carries a bad prognosis. We report a rare case of squamous cell carcinoma gallbladder, which was well differentiated, diagnosed early and resected completely. Postoperatively patient is planned for adjuvant chemotherapy.
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Kumar V, Cotran RS, Robbins SL. Robbins basic pathology. 7th ed, Philadelphia: WB Saunders; 2003.
Ponce LEC, Miquel JF, Munoz N, Herrero R, Ferrecio C, Wistuba II, et al. Epidemiology and molecular pathology of gallbladder cancer. CA Cancer J Clin. 2001;51:349-64.
Zatonski W, Vecchia LC, Levi F, Negri E, Lucchini F. Descriptive epidemiology of gall-bladder cancer in Europe. J Cancer Res Clin Oncol. 1993;119:165-71.
Perisetti A, Raghavapuram S, Tharian B. Pure Squamous Cell Carcinoma of the Gallbladder Masquerading as a Hepatic Mass. Cureus. 2018;10:2011.
Randi G, Franceschi S, Vecchia LC. Gallbladder cancer worldwide: geographical distribution and risk factors. Int J Cancer. 2006;118:1591-602.
Kim JH, Kim WH, Yoo BM, Kim JH, Kim MW. Should we perform surgical management in all patients with suspected porcelain gallbladder. Hepatogastroenterology. 2009;56:943-5.
Duffy A, Capanu M, Alfa AGK, Huitzil D, Jarnagin W, Fong Y, et al. Gallbladder cancer (GBC): 10-year experience at Memorial Sloan-Kettering Cancer Centre (MSKCC). J Surg Oncol. 2008;98:485-9.
Chakrabarti I, Giri A, Ghosh N. Cytohistopathological correlation of a case of squamous cell carcinoma of gallbladder with lymph node metastasis. Turk Patoloji Derg. 2014;30:81-4.
Hady ASM, Saed AA. Primary keratinizing squamous cell carcinoma: an exceptional tumor of the gallbladder. Saudi J Gastroenterol Off J Saudi Gastroenterol Assoc. 1997;3:53-5.
Roa I, Araya JC, Villaseca M, Aretxabala DX, Riedemann P, Endoh K, et al. Preneoplastic lesions and gallbladder cancer: an estimate of the period required for progression. Gastroenterology. 1996;111:232-6.
Kalayarasan R, Javed A, Sakhuja P, Agarwal AK. Squamous variant of gallbladder cancer: is it different from adenocarcinoma. Am J Surg. 2013;206:380-5.
Charbit A, Malaise EP, Tubiana M. Relation between the pathological nature and the growth rate of human tumors. Eur J Cancer. 1971;7:307-15.
Kim WS, Jang KT, Choi DW, Choi SH, Heo JS, You DD, et al. Clinicopathologic analysis of adenosquamous/squamous cell carcinoma of the gallbladder. J Surg Oncol. 2011;103:239-42.
Chan KM, Yu MC, Lee WC, Jan YY, Chen MF. Adenosquamous/squamous cell carcinoma of the gallbladder. J Surg Oncol. 2007;95:129-34.
Wen Z, Si A, Yang J, Yang P, Yang X, Liu H, et al. Elevation of CA19‐9 and CEA is associated with a poor prognosis in patients with re-sectable gallbladder carcinoma. HPB (Oxford). 2017;19:951-6.
Yu TN, Shen B, Meng N, Yu H, Cai XJ. Risk factors of lymphatic metastasis complement poor radiological detection in gallbladder cancer. World J Gastroenterol. 2014;20:290-5.
Corvera CU, Blumgart LH, Akhurst T, Matteo DRP, Angelica DM, Fong Y, et al. 18F-fluorodeoxyglucose positron emission tomography influences management decisions in patients with biliary cancer. J Am Coll Surg. 2008;206:57-65.
Mghirbi F, Ayadi M, Karray W, Yahyaoui Y, Meddeb K, Mokrani A, et al. Squamous cell carcinoma of the gallbladder. Transl Gastroenterol Hepatol. 2016;1:78.
Horgan AM, Amir E, Walter T, Knox JJ. Adjuvant therapy in the treatment of biliary tract cancer: a systematic review and meta-analysis. J Clin Oncol Off J Am Soc Clin Oncol. 2012;30:1934-40.
