Published: 2020-05-26

Presence of Helicobacter pylori infection in gastroduodenal perforations

Kemparaj T., Ashika Bagur


Background: Gastroduodenal perforations constitute one of the commonest surgical emergencies encountered. Helicobacter pylori is a gram negative bacterium that has infected more than half the world’s population. The most commonly recognized manifestation of H. pylori infection in India is peptic ulcer disease. Although the relationship between H. pylori infection and peptic ulcer has been well defined, the relationship of H. pylori infection with gastroduodenal perforation is still controversial. The objective of the study was to determine the presence of H. pylori in gastroduodenal perforations.

Methods: We conducted a prospective study, noting the number of cases which turned out to be positive for H. pylori in cases of gastroduodenal perforations intraoperatively, using rapid urease test.

Results: Out of 100 cases of gastroduodenal perforations operated, 74% were positive for the test. Gastric perforations positive for the test were 81.4% and duodenal perforations positive for the test were 68.42%.

Conclusions: There is a positive attribution between H. pylori infection and gastroduodenal perforations.


Gastroduodenal perforations, Helicobacter pylori

Full Text:



Bali RS, Verma S, Agarwal PN, Singh R, Talwar N. Perforation peritonitis and the developing world. ISRN Surg. 2014;2014:1-4.

Ramakrishnan K, Salinas RC. Peptic ulcer disease. Am Fam Phys. 2007;76(7).

Soriano IS, Dempsey DT. Benign gastric disorders. In: Zinner MJ, Ashley SW, eds. Maingot's abdominal operations. McGraw Hill Professional; 2018;461-465.

Gisbert JP, Legido J, Garcıa-Sanz I, Pajares JM. Helicobacter pylori and perforated peptic ulcer. Prevalence of the infection and role of non-steroidal anti-inflammatory drugs. Digest Liver Dis. 2004;36(2):116-20.

El-Nakeeb A, Fikry A, El-Hamed TM, El Awady S, Youssef T, Sherief D, et al. Effect of Helicobacter pylori eradication on ulcer recurrence after simple closure of perforated duodenal ulcer. Int J Surg. 2009;7(2):126-9.

Pincock S. Nobel Prize Winners Robin Warren and Barry Marshall. Lancet. 2005;366(9495):1429.

Kusters JG, van Vliet AH, Kuipers EJ. Pathogenesis of Helicobacter pylori infection. Clin Microbiol Rev. 2006;19(3):449-90.

Gisbert JP, Khorrami S, Carballo F, Calvet X, Gené E, Dominguez‐Muñoz E. H. pylori eradication therapy vs. antisecretory non-eradication therapy (with or without long-term maintenance antisecretory therapy) for the prevention of recurrent bleeding from peptic ulcer. Cochrane Database Syst Rev. 2004;2:CD004062.

Dogra BB, Panchabhai S, Rejinthal S, Kalyan S, Priyadarshi S, Kandari A. Helicobacter pylori in gastroduodenal perforation. Med J Dr. DY Patil Univ. 2014;7(2):170.