DOI: http://dx.doi.org/10.18203/2349-2902.isj20201518

A comparative study on treatment of keloid with triamcinolone versus 5-fluorouracil and triamcinolone

C. V. Praveen Kumar Reddy, Surekha A.

Abstract


Background: The study was done to assess and compare the treatment of keloids with intralesional triamcinolone and combination of 5-fluorouracil and triamcinolone. Despite various options available, there is no universally accepted treatment for keloids. Our objective was to compare two regimens and establish superiority in terms of objective and subjective outcomes

Methods: A randomized parallel group study conducted in the Department of Plastic Surgery from January 2017 to June 2019. A total of 80 patients were taken with 40 each group.

Results: Though there was improvement in both regimens, this was more significant with combination regimen especially with vascularity, pliability, decrease in height and faster relief of symptoms like pain and itching.

Conclusions: Both were effective in treatment of keloids; triamcinolone alone was having relapse rate and combination therapy was more effective with faster results and few side effects.

 


Keywords


Keloid, Triamcinolone, 5-Fluorouracil

Full Text:

PDF

References


Ghoshal K, Jacob ST. An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug. Biochem Pharmacol. 1997;53:1569-75.

Urioste SS, Arndt KA, Dover JS. Keloids and hypertrophic scars: review and treatment strategies. Semin Cutan Med Surg. 1999;18:159-71.

Bulstrode NW, Mudera V, McGrouther DA, Grobbelaar AO, Cambrey AD. 5-Fluorouracil selectively inhibits collagen synthesis. Plast Reconstr Surg. 2005;116:209-21.

Huang L, Cai YJ, Lung I, Leung BC, Burd A. A study of the combination of triamcinolone and 5fluorouracil in modulating keloid fibroblasts in vitro. J Plast Reconstr Aesthet Surg. 2013;66:251-9.

Sullivan T, Smith J, Kermode J, McIver E, Courtemanche DJ. Rating the burn scar. J Burn Care Rehabil. 1990;11:256-60.

Truong PT, Abnousi F, Yong CM, Hayashi A, Runkel JA, Phillips T, et al. Standardized assessment of breast cancer surgical scars integrating the Vancouver Scar Scale, Short-Form McGill Pain Questionnaire, and patients’ perspectives. Plast Reconstr Surg. 2005;116:1291- 9.

Nanda S, Reddy BS. Intralesional 5-fluorouracil as a treatment modality of keloids. Dermatological Surg. 2004;30(1):54-6.

Kontochristopoulos G, Stefanaki C, Panagiotopoulos A, Stefanaki K, Argyrakos T, Petridis A, et al. Intralesional 5fluorouracil in the treatment of keloids: an open clinical and histopathologic study. J Am Acad Dermatol. 2005;52(3):474-9.

Bijlard E, Steltenpool S, Niessen FB. Intralesional 5-fluorouracil in keloid treatment: a systematic review. Acta Derm Venereol. 2015;95:778-82.

Sadeghinia A, Sadeginia S. Comparison of the efficiency of intralesional triamcinolone acetonide and 5-fluorouracil tattooing for the treatments of keloids. Dermatol Surg. 2012;38;104-6.

Srivastava S, Patil A, Prakash C, Kumari H. Comparison of intralesional triamcinolone acetonide,5-fluorouracil, and their combination for the treatment of keloids. Adv Wound Care. 2017;6:11.

Sharma S, Bassi R, Gupta A. Treatment of small keloids with intralesional 5-fluorouracil alone vs. intralesional triamcinolone acetonide with 5fluorouracil. J Pakistan Assoc Dermatologists. 2012;22:35-40.

Manuskiatti W, Fitzpatrick RE. Treatment response of keloidal and hypertrophic sternotomy scars: comparison among intralesional corticosteroid, 5-fluorouracil, and 585-nm flash lamp pumped pulsed-dye laser treatments. Arch Dermatol. 2002;138:1149-55.