DOI: http://dx.doi.org/10.18203/2349-2902.isj20201387

Clinical study of sterile collagen (Biofil) particles in the management of chronic non healing ulcers and their comparison with saline dressings

Vipul Metta, Prabhat B. Nichkaode, Sunil V. Panchbhai, Sai Charan, Aishwarya Purohit

Abstract


Background: Chronic non healing ulcers are a challenge to the patient and health care professional. They require special care and intensive treatment often for prolonged periods. These ulcers do not generally heal with conventional types of treatment within a reasonable time period and need special types of treatment like collagen particles, vacuum dressing, chemical debridement etc. The aim of the study was to compare the effect of sterile collagen particles with saline dressings in treatment of chronic non healing ulcers.

Methods: 30 test subjects were dressed using sterile collagen particles and 30 controls using saline gauze on day 2 and every 3rd day. The condition of the ulcer was followed up using the Bates-Jensen wound assessment score (BJWA score).

Results: BJWA score was significantly lesser at 4th week in test group. The p value was 0.00021. Test group mean score was 17.23 and for control group it was 21.467. BJWA score was significantly lesser even at 8th week in Test group. The p value was 0.00026. Test group mean score was 12.47 and control group it was 17.43. This signifies that healing rate is better in test group compared to control group.

Conclusions: Comparing the components in BJWA score we can conclude from our study that; collagen dressings are superior to saline dressing in all type of ulcers and irrespective of gender and age of a person. The best response was seen in non diabetic ulcer without Saphenofemoral incompetence who are non smokers.


Keywords


Collagen particles, Chronic ulcers, Bates-Jensen wound assessment score

Full Text:

PDF

References


Leong M, Murphy KD. Wound healing, Sabiston textbook of surgery chapter wound healing, 20th edition, Elsevier; 2017: 130-138.

Examination of ulcer. Chapter 4, S. Das manual of clinical surgery, 9th edition, 2011.

Waago H. Local treatment of ulcers in diabetic foot with human growth hormone. Lancet. 1987;1:1485.

Harris C, Bates-Jensen B, Parslow N, Raizman R, Singh M, Ketchen R. Bates-Jensen wound assessment tool: pictorial guide validation project. J Wound Ostomy Continence Nurs. 2010;37(3):253-9.

Amin N, Doupis J. Diabetic foot disease: From the evaluation of the “foot at risk” to the novel diabetic ulcer treatment modalities. World J Diabetes. 2016;7(7):153-64..

Alzahrani OH, Badahdah YS, Bamakrid MS, Alfayez AS, Alsaeedi MS, Mansouri AM, et al. The Diabetic Foot Research in Arabs Countries. OJEMD. 2013;3(3):157-65.

Saraf SK, Shukla VK, Kaur P, Pandey SS. A clinico-epidemiological profile of non-healing wounds in an Indian hospital. J Wound Care. 2000;9(5):247-50.

Sethia KK, Darke SG. Long saphenous incompetence as a cause of venous ulceration. British J Surg. 1984;71(10):754-5.

Rao H, Pai A, Hussein I, Arun A, Ram HS, Pai A, et al. A comparative study between collagen dressings and conventional dressings in wound healing. Int J Collaborative Res Int Med Health. 2012;4(5):611-23.

Datta AS, Kumar NR, Rajitha NN, Kumar KA, Meher TD. Prospective study on role of collagen granules in management of chronic non healing ulcers. Int J Sci Res. 2019;8(6):43-6.

Chalimidi KR, Kumar Y, Kini UA. Efficacy of Collagen Particles in Chronic Non healing Ulcers. J Clin Diagn Res. 2015;9(6):PC01-3.

Veves A, Sheehan P, Pham HT. A randomized, controlled trial of Promogram (a collagen/oxidized regenerated cellulose dressing) vs standard treatment in the management of diabetic foot ulcers. Arch Surg. 2002;137:822-7.

Singh O, Gupta SS, Soni M, Moses S, Shukla S, Mathur RK. Collagen dressing versus conventional dressings in burn and chronic wounds: a retrospective study. J Cutaneous Aesthetic Surg. 2011;4(1):12-6.