T cell/histiocyte rich large B cell lymphoma of ascending colon: a rare entity
DOI:
https://doi.org/10.18203/2349-2902.isj20200846Keywords:
Colonic epithelial malignancy, Diffuse large B-cell lymphoma, Lenalidomide, Nodular lymphocyte predominant Hodgkin lymphoma, T cell/histiocyte rich large B cellAbstract
Colonic T cell/histiocyte rich large B cell lymphoma (THRLBCL) is a very unusual occurrence never described before. A 41-year anaemic male presented with loss of weight and appetite for 7 months and fever with Malena for 1 month. Abdominal examination revealed a 4×6 cm retroperitoneal lump in the right iliac fossa. Radiological investigations (USG and CECT whole abdomen) reported an asymmetrical ill-defined growth in ascending colon and caecum with loco-regional lymphadenopathy. Surgical exploration revealed an ascending colon mass with retroperitoneal lymphadenopathy. Right hemi-colectomy with end ileostomy was done and specimen was sent for histopathology which diagnosed it to be a case of THRLBCL of colon. Patient was followed up after 2 weeks and was planned for chemotherapy.
References
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon. Inter Agen Res Cancer. 2008: 309-311.
Ioachim HL, Ratech H. Nomenclature and classification of lymphomas. In: Ioachim Lymphnode Pathology. 3rd ed. Philadelphia: Lippincott Williams and Wilkins; 2002: 315-324.
Ichikawa S, Watanabe Y, Saito K, Kimura J, Ichinohasama R, Harigae H. T-cell/histiocyte-rich large B-cell lymphoma of the thyroid. Exper Hematol Oncol. 2013;2(1):1.
Bagwan IN, Knee G, Abboudi Z, Naresh KN. Small intestinal presentation of nodular lymphocyte-predominant Hodgkin lymphoma with T cell/histiocyte-rich B cell lymphoma-like areas-with review of literature on extranodal presentation of this disease. J Hematopathol. 2010;3(1):29-34.
Xu J, Wu X, Reddy V. T Cell/Histiocyte-Rich large B cell lymphoma of the thymus: A diagnostic pitfall. Case Rep Hematol. 2016;2016.
Gocke CD. Non-Hodgkin’s lymphoma. In: Dabbs DJ. Diagnostic Immunohistochemistry. Philadelphia: Churchill Livingstone; 2002:113-34.
Abramson JS. T-cell/histiocyte-rich B-cell lymphoma: biology, diagnosis, and management. Oncologist. 2006;11(4):384-92.
Aki H, Tuzuner N, Ongoren S, Baslar Z, Soysal T, Ferhanoglu B, et al. T-cell-rich B-cell lymphoma: a clinicopathologic study of 21 cases and comparison with 43 cases of diffuse large B-cell lymphoma. Leukemia Res. 2004;28(3):229-36.
Rets AV, Gottesman SR. Nodular Lymphocyte Predominant Hodgkin Lymphoma versus T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: A Diagnostic Challenge. Case Rep Pathol. 2014;2014.
Zhao FX. Nodular lymphocyte-predominant Hodgkin lymphoma or T-cell/histiocyte rich large B-cell lymphoma: the problem in “grey zone” lymphomas. Inter J Clin Exper Pathol. 2008;1(3):300.
Hartmann S, Döring C, Jakobus C, Rengstl B, Newrzela S, Tousseyn T, et al. Nodular lymphocyte predominant hodgkin lymphoma and T cell/histiocyte rich large B cell lymphoma - endpoints of a spectrum of one disease? PLoS One. 2013;8(11):78812.
Franke S, Wlodarska I, Maes B, Vandenberghe P, Achten R, Hagemeijer A, et al. Comparative genomic hybridization pattern distinguishes T-cell/histiocyte-rich B-cell lymphoma from nodular lymphocyte predominance Hodgkin's lymphoma. Am J Pathol. 2002;161(5):1861-7.
Siricilla M, Irwin L, Ferber A. A Case of Chemotherapy-Refractory “THRLBCL like Transformation of NLPHL” Successfully Treated with Lenalidomide. Case Rep Oncol Med. 2018;2018.
El Weshi A, Akhtar S, Mourad WA, Ajarim D, Abdelsalm M, Khafaga Y, et al. T-cell/histiocyte-rich B-cell lymphoma: clinical presentation, management and prognostic factors: report on 61 patients and review of literature. Leuk lymph. 2007;48(9):1764-73.