A comparative study between platelet rich plasma and conventional dressing in chronic non healing leg ulcers


  • Ramakrishna Reddy Gade Department of Surgery, Mamata Medical College and hospital, Khammam, Telangana, India
  • Venkata Reddy M. Department of Surgery, Mamata Medical College and hospital, Khammam, Telangana, India
  • Padmanabh Inamdar Department of Surgery, Mamata Medical College and hospital, Khammam, Telangana, India




Chronic non healing leg ulcer, Platelet rich plasma dressing, Platelet derived growth factor


Background: Chronic non-healing leg ulcers are a major health problem worldwide and have great impact on personal, professional and social levels, with high cost in terms of human and material resources. The present study was conducted with an aim to demonstrate the efficacy of autologous platelet rich plasma (PRP) in chronic non-healing leg ulcers in comparison to conventional dressings.

Methods: A total of 50 patients with leg ulcers were randomized into two groups (A and B) with each group comprising of 25 patients each. Group A were treated with autologous platelet rich plasma (PRP) dressings and group B were treated with conventional dressings using normal saline. Ulcer measurements were taken on day 1, day 7, days 15 and after 30 days. The end point of study was complete wound epithelialization or appearance of granulation tissue, which ultimately lead to spilt skin grafting or secondary healing; whichever is earlier.

Results: There was statistically significant difference in the average time taken for complete healing of ulcer in PRP dressings, 3.68 weeks against 6.2 weeks in conventional dressing group (p value <0.0001). PRP dressing group showed a 43.96% reduction in ulcer size as compared to 13.81% in conventional dressing group (p <0.0001). It was observed that PRP dressing group has faster wound healing and contraction of wound.

Conclusions: PRP dressing of leg ulcers was better than conventional normal saline dressing as it leads to early reduction of ulcer size and enhances rate of wound healing. 

Author Biographies

Ramakrishna Reddy Gade, Department of Surgery, Mamata Medical College and hospital, Khammam, Telangana, India

Senior resident, Department of general Surgery,

Venkata Reddy M., Department of Surgery, Mamata Medical College and hospital, Khammam, Telangana, India

Professor, Department of  general Surgery

Padmanabh Inamdar, Department of Surgery, Mamata Medical College and hospital, Khammam, Telangana, India

Associate professor, Department of general Surgery


Mekkes JR, Loots MA, Van Der Wal AC, Bos JD. Causes, investigation and treatment of leg ulceration. Br J Dermatol. 2003;148:388‑401.

Anderson I. Aetiology, assessment and management of leg ulcers. Wound Essent. 2006;1:20‑36.

Yuan T, Zhang CQ, Tang MJ, Guo SC, Zeng BF. Autologous platelet-rich plasma enhances healing of chronic wounds. Wounds. 2009;21(10):280-5.

Bielecki TM, Gazdzi TS. Percutaneous Injection of Autogenous Growth Factors In Patient With Nonunion of the humerus. A Case Report. J Orthopaedic. 2006;3(3):15.

Sampson S, Gerhardt M, Mandelbaum B. Platelet rich plasma injection grafts for musculoskeletal injuries: a review. Curr Rev Musculoskelet Med. 2008;1:165-74.

Giacco F, Perruolo G, D’Agostino E, Fratellanza G, Perna E, Misso S, et al. Thrombin-activated platelets induce proliferation of human skin fibroblasts by stimulating autocrine production of insulin-like growth factor-1. FASEB J. 2006;20:2402-4.

Sarvajnamurthy S, Suryanarayan S, Budamakuntala L, Suresh DH. Autologous platelet rich plasma in chronic venous ulcers: study of 17 cases. J Cutan Aesthet Surg. 2013;6(2):97-9.

Dionyssiou D, Demiri E, Foroglou P, Cheva A, Saratzis N, Aivazidis C, et al. The effectiveness of intralesional injection of platelet‐rich plasma in accelerating the healing of chronic ulcers: an experimental and clinical study. Inter Wound J. 2013;10(4):397-406.

Eppley BL, Woodell JE, Higgins J. Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plast Reconstr Surg. 2004;114(6):1502-8.

Knighton DR, Ciresi KF, Fiegel VD, Austin LL, Butler EL. Classification and treatment of chronic nonhealing wounds. Successful treatment with autologous platelet-derived wound healing factors (PDWHF). Ann Surg. 1986;204(3):322-30.

Knighton DR, Doucette M, Fiegel VD, Ciresi K, Butler EL, Austin L. The use of platelet derived wound healing formula in human clinical trials. Prog Clin Biol Res. 1988;266:319-29.

Lacci KM, Dardik A. Platelet-rich plasma: support for its use in wound healing. Yale J Biol Med. 2010;83(1):1-9.

Frykberg RG, Driver VR, Carman D, Lucero B, Borris-Hale C, Fylling CP, et al. Chronic wounds treated with a physiologically relevant concentration of platelet-rich plasma gel: a prospective case series. Ostomy/Wound Manage. 2010;56(6):36.

Kakudo N, Kushida S, Ogura T, Hara T, Suzuki K, Kusumoto K. The use of autologous platelet-rich plasma in the treatment of intractable skin ulcer: a case series. OJRM. 2012;1(3):29-32.

Driver VR. Autologel Diabetic Foot Ulcer Study Group. A prospective, randomized, controlled trial of autologous platelet rich plasma gel for the treatment of diabetic foot ulcers. Ostomy Wound Manage. 2006;52(6):68-70,72,74.

Anil K, Sindhuri K. Efficacy of autologous platelet gel versus conventional dressing in chronic wounds-comparative study using PWAT. Inter J Appl Res. 2016;2(9):840-84.

Knighton D, Ciresi K, Fiegel VD, Schumerth S, Butler E, Cerra F. Stimulation of repair in chronic, nonhealing, cutaneous ulcers using platelet-derived wound healing formula. Surg Gynecol Obstet. 1990;170(1):56-60.

Anitua E, Orive G, Aguirre JJ, Ardanza B, Andía I. 5-year clinical experience with BTI dental implants: risk factors for implant failure. J Clin Periodontol. 2008;35(8):724-32.

Divya S, Tushar S. Comparitive Study between Standard Dressing With EUSOL and Topical PDGF in Healing Of Diabetic Foot Ulcer. Ann Int Med Den Res. 2018;4(4):27-9.

Sayed EA, Abd EM, Hazem EA. Platelet-rich plasma versus conventional dressing: does this really affect diabetic foot wound-healing outcomes? Egyptian J Surg. 2018;37:16-26.

Hardikar JV, Reddy YC, Bung DD, Narendrer V, Prakash P, Prasad ED, et al. Efficacy Of rh PDGF Based Gel In Diabetic Foot Ulcers: A Randomized Multicenter, Double Blind, Placebo Controlled Study in India. Wounds. 2005;17(6):141-52.

Bielecki TM, Gazdzik TS, Arendt J, Szczepanski T, Krol W, Wielkoszynski T. Antibacterial effect of autologous platelet gel enriched with growth factors and other active substances: an in vitro study. J Bone Joint Surg Br. 2007;89(3):417-20.






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