DOI: http://dx.doi.org/10.18203/2349-2902.isj20195972

Comparison of free radicals in blood in pre-operative and post-operative phases of breast malignancies: a clinicopathological study

Abhishek Jina, U. C. Singh

Abstract


Background: Various factors have been identified as influencing factors of breast cancer. The free radicals can cause increased oxidative stress by negatively affecting the body’s nucleic acids, lipids and proteins leading to various illnesses including cancer. Therefore, this study was aimed at discovering the progress of treatment of breast carcinoma by exploring the connections of the disease with free radical injury.

Methods: The present study was conducted among 30 breast carcinoma patients received in the surgery department of BRD Medical College Gorakhpur. Determination of the levels superoxide dismutase (SOD) (the procedure of photoluminescence), catalase (method of Cavarochi) and the lipid peroxidise was done. The results were presented as mean and standard error (SE). P value of <0.05 was considered as statistically significant.

Results: Among the total participants, 73% patients had infiltrating ductal carcinoma and 27% patients had intraductal carcinoma. The dismutase levels showed an increase in the post-operative patients for both the groups. The catalase levels and the lipid peroxide levels showed a reduction in the postoperative patients (p<0.05).

Conclusions: The present study result showed that the low amounts of SOD and catalase may not be sufficient to detoxify high amounts of free radicals. The administration of catalase could help in reducing the symptoms. Though, low amounts of SOD and catalase may not be sufficient to detoxify high amounts of free radicals. The administration of enzymes could help in the treatment of breast cancer patients.


Keywords


Free radicals, Oxidataion, Oxidative stress, Superoxide dismutase, Catalase, Lipid peroxidation, Infiltrating ductal carcinoma

Full Text:

PDF

References


Malvia S1, Bagadi SA, Dubey US, Saxena S. Epidemiology of breast cancer in Indian women. Asia-Pacific J Clin Oncol. 2017;13:289-95.

Balekouzou A, Yin P, Pamatika CM, Bishwajit G, Nambei SW, Marceline D, et al. Epidemiology of breast cancer: retrospective study in the Central African Republic. BMC Public Health. 2016;16(1230).

Max D, Johannes S, Toralf R, Nicole E, Anika B. Influence of Lifestyle Factors on Breast Cancer Risk. Breast Care. 2014;9(6):407-14.

Alugoju P, Babu JD, Latha P. Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases. Indian J Clin Biochem. 2015;30(1):11-26.

Sandra RA, Francisco AC, Josefa L, Elisa RM, Maria del Mar SA, Irene C, et al. Involvement of free radicals in breast cancer. Springer Plus. 2013;2:404.

Khan P, Idrees D, Moxley MA, Corbett JA, Ahmad F, von Figura G, et al. Luminol-based chemiluminescent signals: clinical and non-clinical application and future uses. Applied Biochem Biotechnol. 2014;173(2):333-55.

Koszeghyova L, Bobek P. Antioxidative state of the myocardium and kidneys in acute diabetic rats. Physiol Res. 1993;42:251-5.

Dvaladze Allison Lael Ekberg. Living with Breast Cancer: Experiences and Perceptions of Women in Georgia. School of Public Health, Department of Global Health.

Breastcancer.org. Available at: https://www.breast cancer.org/symptoms/types/idc. Accessed on 2 July 2019.

Vaidya Yash, Vaidya Pradeep, Vaidya Tanvi. Ductal Carcinoma In Situ of the Breast. Indian J Surg. 2015;77(2):141-6.

Mohammad EH, Karimova ST, Afandiev AM. Lipid Peroxidation and Antioxidant Status in Breast Cancer Patients before and after Therapy. Med J Cairo Univ. 2009;77(3):37-42.

Narod SA, Javaid I, Vasily G, Victoria S, Ping S. Breast Cancer Mortality after a Diagnosis of Ductal Carcinoma in Situ. JAMA Oncol. 2015;1(7):888-96.

Mahajan M, Tiwari N, Sharma R, Kaur S, Singh N. Oxidative Stress and Its Relationship With Adenosine Deaminase Activity in Various Stages of Breast Cancer. Indian J Clin Biochem. 2013;28(1):51-4.

Singh G, Maulik SK, Jaiswal A, Kumar P, Parshad R. Effect on Antioxidant Levels in Patients of Breast Carcinoma during Neoadjuvant Chemotherapy and Mastectomy. Malayasian J Med Sci. 2010;17(2):24-4.

Negahdar M, Djali M, Abtahi H, Sadeghi MR, Aghvami T, Javadi E, et al. Blood Superoxide Dismutase and Catalase Activities in Women Affected with Breast Cancer. Iranian Journal of Public Health. 2005;34(3):39-43.

Ashraf EB, Raida Y, Hatem E, Eissa Mohammed A, Abo Hossam D, Gad A, et al. Antioxidants status in breast cancer patients under therapy. Am J Res Communication. 2013;1:152.

Malik A, Rasool R, Slayman W, Arooj M, Bukhari MM, Qazi HM. Relationship of prophetic factors associated with antioxidative, immune system and micronutrients status in breast cancer patients underwent surgical procedures. Adv Surg. 2018;2(1):33-9.

Gaweł S, Wardas M, Niedworok E, Wardas P. Malondialdehyde (MDA) as a lipid peroxidation marker. Wiad Lek. 2004;57(9-10):433-5.

Gonenc A, Erten D, Aslan S, Akinci M, Simsek B, Torun M. Lipid peroxidation and antioxidant status in blood and tissue of malignant breast tumor and benign breast disease. Cell Biol Int. 2006;30(4):376-80.

Ray G, Batra S, Shukla NK, Deo S, Raina V, Ashok S et al. Lipid peroxidation, free radical production and antioxidant status in breast cancer. Breast Cancer Res Treatment. 2000;59(2):163-70.

Kasapovic J, Pejic S, Todorovic A, Stojiljkovic V, Pajovic S. Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages. Cell Biochem Funct. 2008.26(6);723-30.

Zarrini AS, Moslemi D, Parsian H, Vessal M, Mosapour A, Kelagari ZS. The status of antioxidants, malondialdehyde and some trace elements in serum of patients with breast cancer. Caspian J Int Med. 2016;7(1):31-6.