Efficacy of laparoscopic splenectomy in thalassemia patients

Authors

  • Ahmed Koshour Department of Surgery, Banha Educational Hospital, Banha, Egypt
  • Moharam Abdelsamie Mohamed Department of Surgery, Faculty of Medicine, Menoufia University, Egypt
  • Mohammed A. Elbalshy Department of Surgery, Faculty of Medicine, Menoufia University, Egypt
  • Mohammed Nazeeh Shaker Nassar Department of Surgery, Faculty of Medicine, Menoufia University, Egypt

DOI:

https://doi.org/10.18203/2349-2902.isj20195380

Keywords:

Laparoscopic splenectomy, Thalassemia, Pfannenstiel incision

Abstract

Background: Haematological disorders in which splenectomy is indicated, the laparoscopic splenectomy became the standard management, except in β thalassemia in which laparoscopic splenectomy still not established yet.

Methods: Thirty patients with thalassemia between November 2017 and April 2019 were operated by anterior approach laparoscopic splenectomy with early ligation of splenic artery then the splenic vein ligated. In initial 12 cases the specimen was extracted via the lower flank port after extending the trocar incision to 10 cm, while through a 7-8 cm Pfannenstiel incision in 17 cases and one case converted to open.

Results: The procedure was completed in 29 patients while one patient converted to open. The mean age of patients was 15.2±3.8 years. The mean operating time was 104±23.5 minutes (90-120 minutes). The mean intra-operative blood loss was 179±37.2 ml (130-250 ml). No major intra-operative complications occurred. Only one patient required intraoperative blood transfusion. The mean postoperative hospital stay was 2.7 days (2-4 days).

Conclusions: Laparoscopic splenectomy is feasible and safe procedure in β thalassemia patients even with huge splenomegaly. The specimen extraction via a Pfannenstiel incision saves more time, carries low morbidity and offer better cosmetic results.

References

Sutherland GA, Burghard FF. The treatment of splenic anaemia by splenectomy. Proc R Soc Med 1911;4:58-70.

Laopodis V, Kritikos E, Rizzoti L, Stefanidis P, Klonaris P, Tzardis P. Laparoscopic splenectomy in β-thalassemia major patients. Surg Endo. 1998;12(7):944-7.

Delaitre B, Maignien B. Splenectomy by the laparoscopic approach. Report of a case. Presse Medicale (Paris, France: 1983). 1991;20(44):2263.

Rosen M, Brody F, Walsh RM, Tarnoff M, Malm J, Ponsky J. Outcome of laparoscopic splenectomy based on hematologic indication. Surg Endo Interventional Tech. 2002;16(2):272-9.

Decker G, Millat B, Guillon F, Atger J, Linon M. Laparoscopic splenectomy for benign and malignant hematologic diseases: 35 consecutive cases. World J Surg. 1998;22(1):62-8.

Ailawadi G, Yahanda A, Dimick JB, Bedi A, Mulholland MW, Sweeney JF. Hand-assisted laparoscopic splenectomy in patients with splenomegaly or prior upper abdominal operation. Surg. 2002;132:689-94.

Patel AG, Parker JE, Wallwork B, Kau KB, Donaldson N, Rhodes MR, et al. Massive splenomegaly is associated with significant morbidity after laparoscopic splenectomy. Annals Surg. 2003;238(2):235-40.

Rosen M, Brody F, Walsh RM, Ponsky J. Hand-assisted laparoscopic splenectomy vs conventional laparoscopic splenectomy in cases of splenomegaly. Archi Surg. 2002;137(12):1348-52.

Rege RV, Merriam LT, Joehl RJ. Laparoscopic splenectomy. Surg Clini North Am. 1996;76(3):459-68.

Thibault C, Mamazza J, Létourneau R, Poulin E. Laparoscopic splenectomy: operative technique and preliminary report. Surgical Laparo Endo. 1992;2(3):248-53.

Wang KX, HU SY, Zhang GY, Bo CH, Zhang HF. Hand-assisted laparoscopic splenectomy for splenomegaly: a comparative study with conventional laparoscopic splenectomy. Chinese Medica J. 2007 Jan 1;120(1):41-5.

Terrosu G, Baccarani U, Bresadola V, Sistu MA, Uzzau A, Bresadola F. The impact of splenic weight on laparoscopic splenectomy for splenomegaly. Surg Endo Other Interventional Tech. 2002;16(1):103-7.

13. Kercher KW, Mathews DB, Walsh RM, Sing FR, Backus CL, Heniford BT. Laparoscopic splenectomy for massive splenomegaly. Am J Surg 2002;183:192-6.

Emmermann A, Zornig C, Peiper M, Weh HJ, Broelsch CE. Laparoscopic splenectomy. Surg Endo. 1995;9(8):924-7.

Poulin EC, Thibault C, Mamazza J. Laparoscopic splenectomy. Surg Endo. 1995;9(2):172-7.

Danforth JD, Fraker DL. Splenectomy for the massively enlarged spleen. Am Surg. 1991;57(2):108-13.

Malmaeus J, Akre T, Adami HO, Hagberg H. Early postoperative course following elective splenectomy in haematological diseases: a high complication rate in patients with myeloproliferative disorders. British J Surg. 1986;73(9):720-3.

Chowbey PK, Goel A, Panse R, Sharma A, Khullar R, Soni V, et al. Laparoscopic splenectomy for hematologic disorders: Experience with first 50 patients. J Laparo Endo Adv Surg Tech. 2005;15:28-32.

Konstadoulakis MM, Lagoudianakis E, Antonakis PT, Albanopoulos K, Gomatos I, Stamou KM, et al. Laparoscopic versus open splenectomy in patients with beta thalassemia major. J Laparo Endo Adv Surg Tech A. 2006;16:5-8.

20. Delaitre B, Maignien B, Lcard P. Laparoscopic splenectomy. Br J Surg. 1992;79:1334.

Park A, Gagner M, Pomp A. The lateral approach to laparoscopic splenectomy. Am J Surg. 1997;173(2):126-30.

Tan M, Zheng CX, Wu ZM, Chen GT, Chen LH, Zhao ZX. Laparoscopic splenectomy: the latest technical evaluation. World J Gastroenterol: WJG. 2003;9(5):1086-9.

Schlinkert RT, Mann D. Laparoscopic splenectomy offers advantages in selected patients with immune thrombocytopenic purpura. Am J Surg. 1995;170(6):624-7.

Gigot JF, de Goyet JD, Van Beers BE, Reding R, Etienne J, Jadoul P, et al. Laparoscopic splenectomy in adults and children: experience with 31 patients. Surg. 1996;119(4):384-9.

Leandros E, Alexakis N, Albanopoulos K, Dardamanis D, Karagiorga M, Gomatos I, et al. Hand-assisted laparoscopic surgery with a Pfannenstiel incision in β-thalassemia patients: Initial experience. World J Surg. 2006;30(7):1216-20.

Al-Salem AH. Indications and complications of splenectomy for children with sickle cell disease. J Pediatr Surg. 2006;41(11):1909-15.

Cohen A, Gayer R, Mizanin J. Long‐term effect of splenectomy on transfusion requirements in thalassemia major. Am J Hematol. 1989;30(4):254-6.

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Published

2019-11-26

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Original Research Articles