The effect of cholecystectomy on the lipid profile of patients with gallstone disease: a prospective study
DOI:
https://doi.org/10.18203/2349-2902.isj20195133Keywords:
Cholecystectomy, Gallstones, Lipid profileAbstract
Background: Gallstones are a common cause for abdominal pain and discomfort. Laparoscopic cholecystectomy is the ‘gold standard’ for the treatment of gallstone disease. The association of gallstones in patients with altered lipid profiles is well documented. Recent studies have shown that there is an improvement in the lipid profile following cholecystectomy. The aim of the study was to study the effect of cholecystectomy on lipid profile and to study the relation between lipid profile and the nature of gallstones.
Methods: Prospective study involving 100 patients admitted to the surgery department for cholecystectomy at Kempegowda Institute of Medical Sciences (KIMS) hospital, Bangalore. Study period was on between October 2016 to July 2018. The pre-operative lipid profile was compared to the post-operative lipid profile done 6 months after cholecystectomy. Gallstone analysis was done with the extracted specimen.
Results: There was a significant improvement in the lipid profiles of study subjects post cholecystectomy. The total cholesterol, low density lipoprotein (LDL) cholesterol, very low density lipoprotein (VLDL) cholesterol and triglycerides decreased significantly (p<0.001) post cholecystectomy. Simultaneously, there was a significant increase (p<0.001) in the high density lipoprotein (HDL) cholesterol levels post-surgery. Majority of the stones were cholesterol stones (51%) followed by pigment stones (6%) and mixed stones (43%).
Conclusions: Cholecystectomy has a favourable effect on the lipid profile of patients. However, we found no correlation between lipid profile and nature of gallstones.
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References
Khuroo MS, Mahajan R, Zargar SA, Javid G, Sapru S. Prevalence of biliary tract disease in India: A Sonographic study in adult population in Kashmir. Gut. 1989;30:201‑5.
Unisa S, Jagannath P, Dhir V, Khandelwal C, Sarangi L, Roy TK, et al. Population‑based study to estimate prevalence and determine risk factors of gallbladder diseases in the rural Gangetic Basin of North India. HPB (Oxford). 2011;13:117‑25.
Shaffer EA. Epidemiology and risk factors for gallstone disease: Has the paradigm changed in the 21st century? Curr Gastroenterol Rep. 2005;7:132‑40.
Sun H, Tang H, Jiang S, Zeng L, Chen EQ, Zhou TY, et al. Gender and metabolic differences of gallstone diseases. World J Gastroenterol. 2009;15:1886‑91.
Liu CM, Tung TH, Chou P, Chen VT, Hsu CT, Chien WS, et al. Clinical correlation of gallstone disease in a Chinese population in Taiwan: Experience at Cheng Hsin general hospital. World J Gastroenterol. 2006;12:1281‑6.
Soper NJ, Stockmann PT, Dunnegan DL, Ashley SW. Laparoscopic cholecystectomy. The new 'gold standard'? Arch Surg. 1992;127(8):917-21.
Singh P, Gupta SK, Kumar M. A comparative study of open cholecystectomy and laparoscopic cholecystectomy in patients with cholelithiasis. Int Surg J. 2018;5:253-6.
Karim T, Kadyal A. A Comparative Study of Laparoscopic vs. Open Cholecystectomy in a Suburban Teaching Hospital. J Gastrointest Dig Syst. 2015;5:371.
Doke A, Gadekar N, Gadekar J, Dash N, Unawane S. A comparative study between open versus laparoscopic cholecystectomy. Sch J App Med Sci. 2016;4(1):57-61.
Gadacz TR, Talamini MA. Traditional versus Laparoscopic Cholecystectomy. Am J Surg. 1999;161:336-8.
Agrawal SN. A study of open versus laparoscopic management of cholecystectomy. International Medical J. 2016;3(2):219-21.
Bell GD, Lewis B, Petrie A, Dowling RH. Serum Lipids in Cholelithiasis: Effect of Chenodeoxycholic Acid therapy. Br Med J. 1973;3:520-3.
Ahmad F, Soomroo I, Maher M. Role of Laparoscopic Cholecystectomy in the Management of Acute Cholecystitis. Annals. 2007;13(4):238-24.
Miller M. Dyslipidemia and cardiovascular risk: the importance of early prevention. QJM: monthly journal of the Association of Physicians. 2009;102(9):657-67
Jindal N, Singh G, Ali I, Sali G, Reddy R. Effect of cholelithiasis and cholecystectomy on serum lipids and blood glucose parameters. Arch Int Surg. 2013;3:97-101.
Gill GS, Gupta K. Pre- and Post-operative comparative analysis of serum lipid profile in patients with cholelithiasis. Int J App Basic Med Res. 2017;7:186-8.
Jain A, Singh MM, Choudhary P. Effect of cholecystectomy on serum lipid profile. Global J Res Analysis (GJRA). 2018;7(4).
Haq AMM, Giasuddin ASM, Jhuma KA, Choudhury MAM. Effect of cholecystectomy on lipid profile in Bangladeshi patients with cholelithiasis. J Metabolic Synd. 2015;4:192.
Ahi KS, Singh RP, Kaur H, Moudgil A. Serum lipid profile in pre and post cholecystectomy patients. Int J Anatomy Radiol Surg. 2017;6(2):1-6.
Malik AA, Wani ML, Tak SI, Irshad I, Ul-Hassan N. Association of dyslipidaemia with cholelithiasis and effect of cholecystectomy on the same. Int J Surg. 2011;9(8):641-2.
Volzke H, Baumeister SE, Alte D, Hoffmann W, Schwahn C, Simon P, et al. Independent risk factors for gallstone formation in a region with high cholelithiasis prevalence. Digestion. 2005;71(2):97-105.
Kurtul N, Pence S, Kocoglu H, Aksoy H, Capan Y. Serum lipid and lipoproteins in gallstone patients. Acta Med. 2002;45(2):79-81.
Saqib A, Shaik SS, Sodhar JM. Gallstones; Frequencies of gallstones in the patients attending surgical OPD at Isra Hospital Hyderabad. Professional Med J. 2014;21(2):386-90.
Pradhan SB, Joshi MR, Vaidya A. Prevalence of different types of gallstone in the patients with cholelithiasis at Kathmandu Medical College, Nepal. Kathmandu Univ Med J(KUMJ). 2009;7(27):268-71.
